Aritra Chatterjee
1.3K posts

Aritra Chatterjee
@bme_aritra
Asst Professor at @IITGuwahati, interested in biomechanics & soft matter; previously at @PurdueBME, @iiscbangalore & @iiest_s and gooner forever @arsenal!
Hyderabad , India Katılım Temmuz 2012
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Interesting! Whenever #Argentina has started out beating one European team, they have defeated three! This actually holds in 86 as well - when they defeated England, Belgium, and W Germany from the quarters in succession. Patterns generally love to repeat, but will they, here?!
Troll Football@TrollFootball
The real reason why Europeans hate Argentina and like Brazil
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Aritra Chatterjee retweetledi
Aritra Chatterjee retweetledi
Aritra Chatterjee retweetledi

@OdedRechavi this is so exciting! to think of the implications of this in the morphogenesisis biophysics point of view is intriguing
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A new mechanism for “RNA memory”! 😱
Thrilled to share another crazy paper from the lab (can’t believe we posted 2 in 2 days!), summarizing >10 years of research:
Work on transgenerational inheritance of small RNAs in the powerful model organism C. elegans changed how we think about what’s possible in inheritance and evolution, because it allows the most heretical thing: inheritance of parental responses to the environment! However, it’s still unclear whether RNAs are inherited across generations in other animals, largely because the RNA-dependent RNA polymerases that amplify heritable small RNAs and prevent their dilution in C. elegans are not conserved in mammals.
In this new work, an amazing collaboration with the Rink and Wurtzel labs, we show that planarians establish long-lasting and heritable small RNA–based gene regulatory states despite lacking canonical RNA-dependent RNA polymerases and nuclear RNAi machinery (that are required in C. elegans).
You might say “they are both worms…” BUT planarians are evolutionarily very distant from C. elegans (flatworms vs. roundworms, diverged more than 500 million years ago), making this particularly surprising. These are totally different animals.
We find that ingestion of double-stranded RNA induces sequence-specific silencing that persists for months and survives repeated cycles of whole-body regeneration. Even more strikingly, RNAi can be transferred between animals, echoing James V. McConnell’s controversial “RNA memory” experiments from the 1970s (his lab was targeted by the Unabomber terrorist Ted Kaczynski, who sent McConnell a bomb. This and other controversies ended this line of experiments…)
Mechanistically, we find that the response transitions from a transient systemic dsRNA-triggered phase to a stable, cell-autonomous post-transcriptional “memory phase” maintained by antisense small RNAs. Using a new luminescence reporter (transgenesis is currently impossible in planarians), we show that silencing spreads along the targeted gene and identify a weird type of planarian small RNAs with untemplated polyA tails.
RNAi inheritance without canonical RdRPs establishes planarians as a powerful system for studying RNA-based regulatory inheritance beyond C. elegans and raises the possibility that RNA-mediated inheritance may be more broadly conserved in animals, potentially even in mammals.
Here’s a video of a planarian that is treated by RNAi against β-catenin and develops multiple heads instead of just one. This is one of the phenotypes that is inherited. Another phenotype is “loss of eyes” (which we show is not only inherited across multiple regeneration cycles, but can also be transmitted between animals in transplantation experiments).
Amazing work led by first authors Prakash Cherian and Idit Aviram (co-supervised by Omri and me).
Please read the preprint, the link is in the next tweet, and share!
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@irohanbaruah Yeah .I haven't felt anything this strong before ..stay safe
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@gabiola442 He also checked Gyokeres' glasses into the crowd.
I hope he stays forever.
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Meet Benny White: elite partying lore of this man:
—Chucked Ødegaard’s £1,200 glasses right into the crowd without a second thought.
—Bullied Rice into performing "Rice, Rice Baby."
—Joyful sang "Hincapie, get your bumm out."
—Someone pelted a burger at the parade bus, and he genuinely just ate it.
You actually cannot convince me there is a bigger legend in the game of partying than him. Ultimate GOAT behavior. 🐐🥳

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Aritra Chatterjee retweetledi

After disappearing from all social media for a while, surviving sleepless nights and somehow managing my cumbersome teaching job, my pre-thesis submission presentations are finally done! Curating a cultural history of Sylhet’s rich folk repertoire has been deeply personal to me. Five years of autoethnographic recollections, painful archival digging, and not to forget the resistance and romance I’ve shared with my work along the way, it all feels material soon!

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