Neurophilia

Openclaw and desktop automation is insane...The prospects are staggering. Here is a surgical construct setup that i was able to generate for a Neurosurgeon

Alzheimer's Disease — Real-World Evidence Updates Lecanemab (Leqembi) Subcutaneous: FDA-approved weekly at-home injection now available — 15-second injection vs. IV infusion Blood-Based Biomarkers: Lumipulse G pTau217/β-amyloid ratio test FDA cleared — may reduce need for amyloid PET in select patients PREVENTION Trial Mid-Trial Results (Jan 2026): Multidomain lifestyle intervention improved cerebral blood flow and insulin resistance in early AD patients with amyloid positivity

HELIUM DEPLETION : GLOBAL MRI MELTDOWN MAY START SOON Iran bombs Qatar helium plant: 33% world supply OFFLINE. MRIs worldwide—threatened. (Helium cools superconducting magnets.) **MEDICAL MAYHEM MAP** (12 countries hit hardest): 🇮🇳 **India**: 1,000s hospital MRIs can dry up. Stroke/brain scans may be delayed; costs +50%. 🇬🇧 **UK**: NHS queues explode. No domestic helium—urgent cases first. 🇺🇸 **USA**: Reserves gone. Neuro/MRI backlogs; hospitals ration. 🇯🇵 **Japan**: MRI giant. 60-day clock to shutdowns. 🇩🇪 **Germany**: Prices doubled. 🇰🇷 **Korea**: Hospitals + Samsung fabs compete for scraps. 🇹🇼 **Taiwan**: TSMC chips for med devices at risk. 🇸🇬 **Singapore**: Regional health hub exposed. 🇨🇳 **China**: MRI imports falter; local hunt ramps. 🇦🇺 **Australia**: Exports can't cover gap. 🇶🇦 **Qatar**: 14% capacity PERMANENTLY damaged (5 years). **Why care?** No helium = no MRIs = delayed stroke diagnoses, tumor misses, neuro emergencies. Tech (phones/chips) secondary—patients first. 12 nations. Zero fixes. Your next brain scan? At risk. 1/2 🧠 #MRIcrisis #HeliumShortage ORDER MRI judiciously and look for other alternatives if the supply chain fails!

If you’re old enough to remember Einsteins analogy of gravity influencing and curving space time. 🛰️🚀 Here’s an analogy of brain function as a nonlinear dynamical system shaped by the structural connectome, that will blow your mind! 🧠Neural activity tries to settle into stable patterns called attractors—like fixed points (steady states) or oscillations (rhythmic patterns). Core Mechanism •Connectome constraints: White matter links dictate which brain regions interact and how strongly, limiting possible activity states. •Nonlinear interactions: Excitation and inhibition create multistability, allowing multiple attractors. •Transitions: External stimuli (tasks) perturb the system, shifting it between attractors—like a ball rolling into new valleys in a connectivity-shaped landscape. Rest vs. Task States •Resting state: Explores intrinsic attractors, forming networks like the default mode network (DMN) with variable activity. •Task state: Input constrains activity into specific, less variable attractors. Key Findings and Clinical Ties •Activity is discrete and anatomy-driven, not random—explaining resting fluctuations, task responses, and diseases. •Disorders: Alter the “attractor landscape” (e.g., depression’s rigid negative states, epilepsy’s hypersynchronous ones, schizophrenia’s unstable shifts). •Therapies: TMS or DBS can nudge the brain out of pathological attractors or stabilize healthy ones. Basically the brain networks like gravity find out curvatures and settles into them ( either resting state or activity dependent- which are stable and allows the network to switch back and forth ) In contrast, disease states are associated with very deep (stuck states) , hyper synchronous states or very shallow and disorganised states ( schizophrenia) Fascinating concept isn’t it ? Ref : doi.org/10.7554/eLife.…

@nodisability I think it is the symmetry on MRI + location+ presentation + family history

@bobvarkey What's classical to think GFAP mutation in MRI here? Owls eye?

A young man 👨 with slowly progressing gait disorder and sleep apnea (due to recurrent tongue fall back at night) Mother died of a similar illness Mri shows this

@jordan_ross_8F OPENCLAW

The founders who figure out OpenClaw in the next 90 days are going to look like geniuses in 2027. The problem is most agency owners don't have time to figure out the install, the security risks, where to start, or what to actually hand it first. So my team built a 48-page beginner's guide that does it for you. Inside: — The exact prompts to hand it on day one — Plain English setup for Mac and Windows — How to secure it so it doesn't burn your business down — 42 copy-paste workflows across sales, marketing, ops, and finance Your competitors are sleeping on this. Comment OPENCLAW and I'll send it.

@Drkrishna_ It was a great lesson for me too

@bobvarkey Ooh this looked like olivo ponto cerebellar degeneration. Thanks for the education

@aditya_gan3500 Your clinical acumen is par excellence Aditya!

@aditya_gan3500 His mother had it Not him

Clinical exome sequencing shows GFAP mutation consistent with 🧠 Alexander Disease Final Dx - Alexander Disease Bulbospinal variant 🔬 Pathophysiology • Cause: Gain-of-function mutations in GFAP gene (chromosome 17q21) • Hallmark: Rosenthal fibers — protein aggregates in astrocytes containing GFAP, heat shock proteins, ubiquitin • Mechanism: Abnormal GFAP crosslinking via oxidation and ubiquitination (Lin et al., 2024) 👤 Clinical Phenotypes Revised Classification (2011): • Type I: Cerebral, early onset, median survival ~14 years • Type II: Bulbospinal, later onset, median survival ~25 years 🩺 Diagnosis • MRI: 4 of 5 criteria needed (frontal WM predominance, periventricular rim, basal ganglia abnormalities, brainstem involvement, contrast enhancement) • Genetic testing: Confirms diagnosis 💊 Treatment Breakthrough ⭐ Zilganersen (ION373) — Antisense oligonucleotide suppressing GFAP production: • Phase 1-3 trial completed (September 2025) • 33.3% improvement in gait speed vs placebo • FDA Breakthrough Therapy Designation (December 2025) • NDA submission expected Q1 2026 📊 Prognosis • Average age at death: 18.6 years • R239 mutations = worse outcomes • Type I: ~14 years; Type II: ~25 years median survival

The anterior circulation in all its glory

@dhruv_rathee Why is this reel getting blocked in India? Whats wrong in it? Why is Ashwini Vaishanav offended by this ? He didnt even say LavdeNa Bhojyam in the reel!

@starks_arq Link is not working

Join my telegram channel for free sauce t.me/+ku5AY7I7G8ZiY…

@starks_arq Tg channel?

Comparing the safety and efficacy of stent retrievers (SR), contact aspiration (Asp), and a combined mechanical thrombectomy (cMT) for LVO ischemic stroke. How do they fare ? doi: 10.1136/jnis-2025-023921. Network Meta-Analysis Summary (24 studies, 12,845 patients): • All 3 techniques = similar overall outcomes • cMT → best first pass effect • Contact aspiration → fastest, fewer dissection complications • Stent retriever → lowest ICH risk Clinical Takeaway: No clear winner. Technique choice should depend on operator expertise, anatomy, and patient factors. The "best" device is the one you're most comfortable with. Source: J Neurointerv Surg 2025, PMID: 41176325

@alex99655 @hasantoxr @grok @grok difference between this and openclaw

@hasantoxr @grok difference between this and openclaw

🚨 BREAKING: You can now run a full AI agent on your desktop without touching a terminal once. Skales runs on 300MB RAM and installs in 30 seconds on Windows and macOS. - 11+ LLM providers (Claude, GPT, Gemini, Grok, DeepSeek, Ollama...) - Browser automation, Gmail, Google Calendar, Twitter/X built-in - Bi-temporal memory that learns your preferences automatically - Autonomous "Chief of Staff" mode that executes tasks while you sleep Free for personal use.

Acquired pendular vertical nystagmus appearing 2 years after a bimedullary stroke