Amir Meghdadi

(1/n) 🧵Publication alert: Our latest work on #EEG #Biomarkers in MCI and #Alzheimers disease is published in @PLOSONE. In this thread, I will highlight the main findings. Check out the open access link here: journals.plos.org/plosone/articl…

@CTADconference Visit poster P333 today to learn about how we use #EEG and #ERP as biomarkers of #cognitive decline in #Alzheimers disease.

Face perception relies on neural mechanisms that rapidly extract identity and emotion. In major depressive disorder (MDD), these mechanisms may be altered, showing heightened sensitivity and biased processing toward emotional faces. #Sfn2025 #SfN25

#Ketamine’s therapeutic effects in patients with recurrent #depression and the associated #EEG and #ERP changes. #Sfn2025 abstractsonline.com/pp8/#!/21171/p…

At #Parkinson's Empowerment Day with my colleagues at ABM. We invited attendees to learn about participation in our ongoing research focused on identifying #EEG #biomarkers for #neurodegenerative diseases such as #Parkinsons and #Alzheimers.

Advanced Brain Monitoring secures #NIH funding to develop EEG/ERP biomarkers of cognitive impairment in Long COVID. 🧠 I am grateful to @NIH for supporting this work. #EEG #LongCovid #NeuroCovid reporter.nih.gov/project-detail…

@melnykowycz @IDUNTech How well does it work though? Have you done experiments to measure its effectiveness?

A Faraday Cage is a great addition to any EEG Neurotech research / development lab. You avoid the mains line noise of 50 Hz in Europe and can better understand the signal your system is measuring. We have a simple and effective solution at @IDUNTech for EEG earbuds dev.

@DaniBeckman Amazing picture. Can you please elaborate a bit more on how the picture shows the reaction of Astrocytes? Does the picture shows astrocytes only and not neurons? Are they breaking up the plaques?

Astrocytes🔵 reacting to B-amyloid🟣 accumulation in the Human Neocortex. One of the hallmarks of #Alzheimers and other neurodegenerative conditions. What if viral infections increase the accumulation of these and other misfolded proteins in the brain? 🤔🔬#FluorescenceFriday

@cbarbermd @DaniBeckman Please be cautious, AI model are often full of inaccuracies if asked about specific scientific topics. A “quick GPT search” is great to provide some directions for researching the topics, but the responses should not be trusted as facts.

Believe there has been some work on this. A quick GPT search returns this, in case any is helpful: Key Studies Linking Viruses to Misfolded Protein Buildup: 1. SARS-CoV-2 (COVID-19) Emerging evidence indicates that even mild cases of COVID-19 can lead to long-lasting brain effects, including the accumulation of misfolded proteins. A study from Imperial College London found that individuals who had contracted COVID-19 exhibited biomarkers associated with Alzheimer's disease, suggesting that SARS-CoV-2 infection might elevate the risk of future neurodegeneration. The Sun 2. HIV: Research has detected misfolded protein aggregates of amyloid-beta and tau in the brains of people living with HIV. This finding suggests that HIV infection may contribute to neurodegenerative processes similar to those observed in Alzheimer's disease. Alzheimer’s Journal 3.CMV: Chronic gut CMV infection is linked to tau and amyloid deposition in the brain, possibly via the vagus nerve. Health.com 4. HSV-1: HSV-1 infection in neurons increases amyloid-beta and phosphorylated tau, core Alzheimer’s proteins. PMC8033564 5. Viral Proteins & Tau Spread: Studies have demonstrated that certain viral proteins can enhance the intercellular spread of misfolded proteins like tau. For instance, the spike protein of SARS-CoV-2 has been shown to increase the transmission of misfolded tau between cells, potentially accelerating neurodegeneration. Alzforum

@francoisfleuret Except, that’s usually not how it works at least in “science” topics. First you indicate what you intend to do and the expert approve it. Then you complete it (and consult with the said expert along the way), and finally the experts approve the work. The reason: statistics

Hot take: Anybody should have the possibility to knock at a University door saying "I did this cool thing working at home the last three years, can you give me a phd title" Three experts would review the request, we would have a three-day "defence" to avoid cheats. 1/2

@DrNeuroChic @Clarivate Invest half an hour on Zotero (free) and you will never come back to Endnote. Remember to install the plugin for your browser. Surf the web and cite at the same time!

In case it helps save someone from wasting a couple hours of their life, #EndNote seems to not be handshaking with #PubMed. Tried switching computers, rebooting, updating EndNote, and typing various combinations. Fortunately @Clarivate Web of Science selection under 'Online Search' working well.

@DaniBeckman More explanation would be great. Is this raptured vessel? What are the pink dots? Amazing picture.

Blood vessel in the brain for #FluorescenceFriday! Major components of the 'blood-brain barrier' are in this photo. This 'barrier' is just a bunch of cells that can be hijacked by viruses but block most antiretroviral drugs' access to the brain. What is the future? Nanoparticles?

@NTFabiano To me, this question, rather than questioning depression as a diagnosis, posed the possibly philosophical question of “what do we really mean by diagnosis?”. Especially when there is no evidentiary biological pathology 🤔

So, I now pose the question: Is depression really a diagnosis, or is it better perceived as a cluster of symptoms? 9/13

There are 60,479,984 ways that symptoms can be combined for the diagnosis of a major depressive disorder. 🧵1/13

Researchers paid $8.968 billion for their findings to be freely accessible. 🧵1/10

@AndrewHires What I would really want to know is that how much of the quality of its response depends on the last part of the prompt: “make sure you do a good job”! It would be another level fascinating if we need to request, remind(?), negotiate (?) to an AI to do a better job!

Testing out DeepSeek-R1's ability to do "science" in one-shot. I asked it to critique my 2017 R01 proposal which was scored Impact 26, 10% percentile, and funded by NINDS. (I wrote the proposal, I have the rights to share it with anyone or anything). I uploaded a PDF of my Specific Aims and Research Strategy with the following, off-the-cuff prompt. It spit out a credible critique indistinguishable from a median quality reviewer's submission after 10 seconds of thought. Overall impact score 2. Thank you! If this is what a free tool can do TODAY in 10 seconds of inference, on the first shot with zero iteration in prompting or followup, what actual role are humans going to play in the process of science going forward? Would you rather have your multi-million dollar, career milestone proposal be critiqued by a super-intelligent AI agent, or by a tired, over-worked, potentially biased human? It seems quite plausible that generating new, evidence-supported hypotheses and experimental plans could already be better accomplished by frontier models (with or perhaps without human prompting) than by humans alone. What do we do now?

Very interesting but let’s not forget that “correct diagnosis” here is the ground truth provided by us, not AI. In other words, this could just mean that the collective knowledge of many doctors (AI knowledge base) outperforms the average of the performance of the said doctors.

For insights into our current findings in this ongoing project, explore our recent publications: x.com/brainsignals/s… x.com/brainsignals/s…

We demonstrated our non-invasive #EEG technology for assessment of #brain health, inviting attendees to participate in our @NIHAging supported study of #EEG #biomarkers for #neurodegenerative diseases like #Parkinson’s and Alzheimer's.

Advanced Brain Monitoring, exhibiting at the #Parkinson's Association of San Diego's Empowerment Day, empowering patients to live their best lives with #Parkinson’s Disease, while showcasing the latest advancements in treatment and disease management.

@fabnascimen @KNascimenski @SBeniczky @EpiDisorders Can someone send me the full text, please. Thank you!

On #EEG, a patient has an alpha rhythm frequency (aka PDR) of 12 Hz. If a slow alpha variant is present, which of the following is its most likely frequency? @KNascimenski @SBeniczky @EpiDisorders pubmed.ncbi.nlm.nih.gov/39560654/

@GorsevYener @BabiloniClaudio @GntknB @NataliaJaworska Looks like a great conference that I had to miss this year.

IPEG 2024 was held in İzmir, a big event for neurophysiologists of cognitive and mental disorders with a twist of deep learning at Izmir University of Economics. Thanks to all speakers and participants. @BabiloniClaudio @GntknB @NataliaJaworska