@ctatedev Does all of your relevant data sit in the cloud also? Doesn’t that present some security vulnerability?
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Bruce Lambert
9.1K posts
Bruce Lambert
@bruce_lambert
Using communication to improve quality and safety of healthcare. Tweets my own. https://t.co/aMHsWCgzYW
Chicago,IL Katılım Mart 2011
2.3K Takip Edilen2K Takipçiler
~100% of my dev is done in sandboxes in the cloud
Highly recommend it:
- Unlimited parallel agent sessions
- My local machine stays safe
- Can work from anywhere
- Can close laptop
- Lap stays cool
Interesting idea to visualize with Kanban
Ryan Carson@ryancarson
100% of dev is going to be done in sandboxes in the cloud, controlled by kanban boards. Trust me, I love my local machine and gorgeous mac apps, but all of it is just a terrible form factor for running a team of agents effectively.
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Bruce Lambert retweetledi
Timely reminder of when this guy reviewed that guy...
Iggy Pop on Gibbon's Decline and Fall (Classics Ireland, 1995):
Caesar Lives by Iggy Pop
In 1982, horrified by the meanness, tedium and depravity of my existence as I toured the American South playing rock and roll music and going crazy in public, I purchased an abridged copy of The Decline and Fall of the Roman Empire (Dero Saunders, Penguin).
The grandeur of the subject appealed to me, as did the cameo illustration of Edward Gibbon, the author, on the front cover. He looked like a heavy dude.
Being in a political business, I had long made a habit of reading biographies of wilful characters — Hitler, Churchill, MacArthur, Brando — with large profiles, and I also enjoyed books on war and political intrigue, as I could relate the action to my own situation in the music business, which is not about music at all, but is a kind of religion-rental.
I would read with pleasure around 4 am, with my drugs and whisky in cheap motels, savouring the clash of beliefs, personalities and values, played out on antiquity’s stage by crowds of the vulgar, led by huge archetypal characters.
And that was the end of that. Or so I thought. Eleven years later I stood in a dilapidated but elegant room in a rotting mansion in New Orleans, and listened as a piece of music strange to my ears pulled me back to ancient Rome and called forth those ghosts to merge in hilarious, bilious pretence with the Schwartzkopfs, Schwartzeneggers and Sheratons of modern American money and muscle myth. Out of me poured information I had no idea I ever knew, let alone retained, in an extemporaneous soliloquy I called ‘Caesar’.
When I listened back, it made me laugh my ass off because it was so true. America is Rome. Of course, why shouldn’t it be? All of Western life and institutions today are traceable to the Romans and their world. We are all Roman children for better or worse. The best part of this experience came after the fact — my wife gave me a beautiful edition in three volumes of the magnificent original unabridged Decline and Fall, and since then the pleasure and profit have been all mine as I enjoy the wonderful language, organization and scope of this masterwork.
Here are just some of the ways I benefit:
I feel a great comfort and relief knowing that there were others who lived and died and thought and fought so long ago; I feel less tyrannized by the present day.
I learn much about the way our society really works, because the system-origins — military, religious, political, colonial, agricultural, financial — are all there to be scrutinized in their infancy. I have gained perspective.
The language in which the book is written is rich and complete, as the language of today is not.
I find out how little I know.
I am inspired by the will and erudition which enabled Gibbon to complete a work of twenty-odd years. The guy stuck with things. I urge anyone who wants life on earth to really come alive for them to enjoy the beautiful ancestral ancient world.
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I was concerned you weren't going to mention the risks of psychedelics. Your claim that they could be managed more easily than the well-known risks of antidepressants at this point is really just optimistic speculation. There's no evidence that this is true because these drugs haven't been used in general practice yet. When they are, we will see that they have widespread risks, some of which are already understood and some of which will only emerge when a larger population is exposed. Psychedelics will be like all other drugs. They will have risks, benefits, and alternatives. Some of the risks of psychedelics are quite complex to explain to patients and, at least in a small minority, can be powerfully negative and long-lasting. For example, how are we going to explain to a patient who's about to take psychedelics that they might experience ontological shock or that they might meet alien entities? I'd like to know how that informed consent conversation goes.
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for psychedelics. Psychedelics have their own set of risks that shouldn't be neglected, but I think these risks can be both screened for and navigated more tractably than standard AD risks. Cost is another issue, but can be decreased, and other treatments are similarly expensive
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This is great work! But I fear that the headlines will lose important parts of the plot (as the below headline suggests). As @RCarhartHarris points out in the below thread, psychedelics both avoid the side effects of standard antidepressants, and (1/n)
x.com/RCarhartHarris…
Balázs Szigeti@psybalazs
🚨MAJOR NEW PAPER 🚨 just out in @JAMAPsych : Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions (tinyurl.com/yu2rbtaf). I am very proud of this one, was a lot of work for me - both co-first and last author! Eternal gratitude to co-first @QuantPsychiatry and twitterless Hannah Barnett! The premise is that it is biased to compare open-label trials (=where patients know what treatment they are getting) to blind trials (=where patients do NOT know what they are getting). Open-label trials would gain an unfair advantage by higher placebo response. Even formally blinded psychedelic trials are practically open-label as its obvious to distinguish placebo from 25mg of #psilocybin. In contrast, traditional antidepressants (SSRIs/SNRIs) trials are are close to be truly blind (Lin 2022). Given the bias of open-label vs. blinded comparison, we compared the efficacy of psychedelic-therapy (which is practically always open-label) vs. open-label antidepressants for the treatment of major depression. We tested 3 prior hypothesis: - There will be a significant difference between psychedelic-therapy vs. open-label antidepressants, favoring psychedelic-therapy. - There will be a significant difference between blinded and open-label antidepressants trials, favoring open-label. - There will NOT be a significant difference between blinded and open-label psychedelic-therapy, as practically they are always open-label. In contrast with our prior hypothesis, we did not find psychedelic-therapy to be more effective than open-label antidepressants (H1). Not only was the difference not clinically meaningful, but practically there was no difference at all. This finding means that antidepressants administered knowingly to patients, which is the case in real-life medical practice, is as effective as psychedelic-therapy. This result was robust across variations in study selection, including when we removed psychedelic-therapy trials on treatment-resistant depression. We also assessed the impact of blinding in both psychedelic-therapy and antidepressants trials. We found that for antidepressants (H2), but not for psychedelic-therapy (H3), open label is associated with better outcomes than blinded treatment. However, even in the case of antidepressants, the difference was practically small (~1.3 HAMD units). How come hypothesis 1 failed, i.e. that psychedelic-therapy is no ore effective than open-label antidepressants, given that antidepressants trials are famous for small drug-placebo difference (~2.4 HAMD units), while psychedelic-therapy trials reported large effects (~7.3)? The key factor is that in psychedelic trials the placebo response is about 50% relative to antidepressants, ~ 4 vs 8 HAMD units (Hsu 2024, Hieronymus 2025). This suppressed placebo response leads to an inflated between-arm difference, as the treatment arm is measured against a lower floor. The suppressed placebo response in psychedelic-therapy trials is likely attributable to the ‘know-cebo’ effect, i.e. the disappointment when patients realize they are in the control group. In psychedelic-therapy trials, this placebo suppression accounts for 4.0 / 7.3 ~ 55% of the specific treatment effect. In other words, ~55% of psychedelic-therapy’s effect is not explained by patient improvement after the treatment, but rather by the lack of improvement in the placebo group. In summary, we found that for the treatment of depression, psychedelic-therapy is no more effective than open-label SSRIs/SNRIs. Our results for psychedelics are twofold: psychedelic-therapy demonstrated a robust and large therapeutic effects (~12 HAMD units), which justifies optimism. On the other hand, psychedelic-therapy’s lack of superiority compared to open-label SSRIs/SNRIs highlights the influence of blinding integrity and argues against overly optimistic narrative's about psychedelic-therapy's potential.
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Bruce Lambert retweetledi
The Afroman Trial.
-Cops raid Afromans house for bullshit reasons.
-Steal money, break his door, fuck his house up.
-No criminality found whatsoever, no charges at all pressed on Afroman.
-Afroman spends the next 3 years making songs that make fun of all the officers involved by name, even using footage of the raid from his own CCTV cameras.
-Songs had titles like "Randy Walters is a son of a bitch" and "Lick Em Low Lisa" accusing one of the officers of being a lesbian and sleeping with the other officers wives.
-During the raid one officer looked like he was about to eat some lemon pound cake sitting on Afromans counter, Afroman made a whole album calling the officer fat.
-The cops get mad and file a lawsuit for defamation.
-Afroman turns up to court in a whole American flag suit.
-Officers performatively mald and cry while listening to the songs really trying to oversell how badly the songs upset them.
-One officer was suing because Afroman made a whole song about him saying he was fucking the officers wife. When the officer was asked if Afroman was really fucking his wife, he said "I don't know". Nuking his own case and establishing that there is a non-zero chance that Afroman might actually be fucking his wife.
-As his only witness for the trial, Afroman brought a deputies EX FUCKING WIFE.
-The jury ruled completely in favour of Afroman.
This entire thing has been a great win for free speech and absolutely fucking hilarious.
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It’s not a negative result. Not bent better than the best available treatment is not negative. It means psychedelics may be an equally effective alternative to the best available drugs for depression. And for patients and families, it’s a good thing to have more alternatives. For many people, SSRIs stop working or have intolerable side effects. For those people, these alternatives might be a godsend. Now, we have decent evidence (at least in the open-label trials) that they are equally effective. Time will tell what their specific advantages and disadvantages are in better controlled trials.
I think the deeper problem that this most recent meta-analysis reveals is that functional unblinding is a very significant threat to the validity of psychedelic trials, and that problem has not been solved.
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🚨 THE BIGGEST NEGATIVE RESULT IN PSYCHIATRY
Psychedelics look like miracle cures for depression when compared to placebos.
But a new meta-analysis asks: what if we compare them to open-label antidepressants?
The massive psychedelic advantage vanishes 🧵
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@ramez Wow. I wonder if you knew my old friend Greg Sullivan during your Microsoft days.
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It depends on the circumstances. If it seemed like a rational well thought out choice, and they had good evidence for it, corrected promptly, and did thoughtful analysis of how to do better in the future, maybe not. I once spent $100m badly at Microsoft. (With Satya and BillG's approval, naturally.) When you're operating a business at the trillion dollar scale, you need to make big bets. You'll get some wrong. Learn from them.
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@sarahditum @BradWilcoxIFS @unherd Sounds like a person who has no actual moral center or durable convictions. And someone who thinks reality will bend to her perverse ideology. But in the end, reality is unbending to all of us, and thus it is not surprising that she is miserable. Nice profile though.
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How did the self-appointed tormenter of Bad Men ™ end up writing propaganda for the surrendered life? And why did she stop being funny? They're not unrelated questions. Me for @unherd unherd.com/2026/03/how-li…
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Lindy West invented the voice of 2010s internet feminism - abrasive, bratty and seemingly fearless. Now she's written a memoir about how she convinced herself that she was fine, actually (completely fine!) with her husband moving his girlfriend into their home. Link follows...
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@ramez That’s a useful framing, but I can’t help but think that if someone lower down the org had made a mistake that cost the company $650 million, they’d be out of a job.
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@bruce_lambert Don't think of it as pissing away. Think of it as a small part of a portfolio of investments, and one of the higher risk ones, which didn't turn out. If every investment you make works, you're probably not taking enough risks.
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@sentdefender The Surrender Caucus puts out a press release.
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The United Kingdom, France, Germany, Italy, the Netherlands and Japan have released a joint statement expressing their readiness to contribute to appropriate efforts to ensure the safe passage of commercial shipping through the Strait of Hormuz.
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@ramez But still, no consequences. Just pissing away $650 million. “Oops, my bad!”
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@bruce_lambert It's not a lot of money to have spent on a bet on talent, when you're spending $100B or more a year in datacenter capex.
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Their logic: smoking today makes you want to smoke more tomorrow — each cigarette raises the value of the next one. A rational person knows this going in and still chooses to start, because the pleasure now outweighs the future cost. That’s not a disease. It’s a tradeoff.
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Why do smokers keep smoking when they know it might kill them? The standard answer: addiction is a disease that overrides choice. My advisor Gary Becker and my friend Kevin Murphy argued the opposite. Addicts are rational.
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I’ve had a variety of similar experiences, but in a different domain, health services research on medication safety. My view now is that somewhere between 50 and 100% of the time you save doing the analysis and getting a skeleton of the paper is consumed later in verification and validation. I still feel overall it’s a good trade-off. I also feel that some sort of adversarial use of multiple models on the same analysis plan and on the same manuscript is useful. I normally start with Claud code and then I ask either ChatGPT Pro or Codex to do an adversarial analysis. I also make use frequently of a prompt where I say “look at this again with fresh eyes and see if you can find any problems.“
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I wrote a substack today where I tried to explain my views about how complementary Claude code is to your work when you have real expertise in that specific area, and how sketchy it is when you don’t.
causalinf.substack.com/p/claude-code-…
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@s8mb There’s no way anyone who has the technical skill to set this up is ever going to wear a tie.
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If you give Claude Code access to your work calendar and Slack, you can pretty easily set it up to scan your calendar for tomorrow and tell you things like (a) where you need to be for your first appointment, (b) what you likely need to wear (tie/no tie, heavy coat/none), (c) any clashes you need to resolve, and (d) any documents you might need to read.
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There is interesting variation in what happened to youth well-being. The drop is biggest in the Anglo countries. Many developing countries rising.
I learned a lot from engaging with the other authors of the World Happiness Report 2026. See whole report here. My chapter is #3
worldhappiness.report
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𝗣𝗢𝗠𝗣𝗘𝗢: 𝗧𝗛𝗘 𝗦𝗧𝗥𝗔𝗜𝗧 𝗢𝗙 𝗛𝗢𝗥𝗠𝗨𝗭 𝗜𝗦 𝗔𝗕𝗢𝗨𝗧 𝗧𝗢 𝗕𝗘 𝗙𝗥𝗘𝗘𝗗 𝗙𝗢𝗥 𝗚𝗢𝗢𝗗
Former Secretary of State and CIA Director Mike Pompeo — a man who spent years in the room where these decisions are made — just said something that deserves to be heard clearly: the Strait of Hormuz hasn't truly been open for thirty years. Iran has been holding it over the world's head for decades — using the threat of closure as a permanent economic weapon against every nation that depends on Gulf oil. That's a fifth of the world's energy supply held hostage by a terrorist regime.
That ends now. Not temporarily. Not for a few weeks until the next crisis. 𝗙𝘂𝗻𝗱𝗮𝗺𝗲𝗻𝘁𝗮𝗹𝗹𝘆 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁 𝗳𝗼𝗿 𝗮𝗻 𝗮𝘄𝗳𝘂𝗹𝗹𝘆 𝗹𝗼𝗻𝗴 𝘁𝗶𝗺𝗲.
The military is doing the preparation — clearing the mine-laying capability, degrading the missile systems that threaten commercial shipping, building the conditions for a sustained reopening rather than a temporary one. Think weeks, not days. It's conditions-based, not calendar-based. But Hegseth and the Chairman of the Joint Chiefs are doing the work, and the goal isn't a press release — it's permanent structural change to the threat environment.
Think about what that means economically. Every risk premium baked into global energy prices for the last fifty years has included an "Iran factor" — the cost of doing business in a world where one murderous theocracy could choke off global oil supply on a whim. That premium affects every airline ticket, every grocery delivery, every manufacturing cost on the planet. Removing it isn't just a military victory. It's an economic one felt by every person on earth who heats a home or fills a tank.
Seven presidents promised Iran would never get a nuclear weapon. None of them dealt with the underlying regime. Trump isn't just hitting the nuclear program — he's removing the hand on the spigot entirely.
This is what the media is calling a stalemate.
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@florianederer It’s about 2 years of free cash flow at current revenue levels. Was even larger proportion when the money was spent. More than rounding error, but not a threat to survival by any means.
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$80 billion is a rounding error for Meta and the computing power used for the Metaverse was probably just repurposed for AI.
Polymarket@Polymarket
JUST IN: Meta announces they'll be shutting down the Metaverse, after pouring $80,000,000,000.00 into the project.
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Bruce Lambert retweetledi
