calafell

Wonderful work, David! The concept that ETC flux—not ATP—licenses cDC1 immunogenicity through /metabolite control of DNA methylation is conceptually beautiful. Congrats to Ignacio, Stefanie and the whole team! Thanks for giving us the chance to learn throught this collaboration!

Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing science.org/doi/10.1126/sc…

Skin #TMA samples, designed by @calafell_p a very nice way to optimize the #Xenium slide space! Skin is also a very difficult tissue to work with... thankfully we got nice results :)

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica nature.com/articles/s4158…

🚨 New paper alert 🚨 Our Human Microglia Atlas (HuMicA) characterizes #microglia subpopulations across 6 distinct #neurologic diseases. @RMartinsFerr @calafell_p @CarrerasIJC nature.com/articles/s4146…

Never too late to celebrate a #NewYear with the team #epigenetics & #immunology

🚨Researchers at @eballestar's lab describe the abnormal immune response in CVID patients under SARS-Cov2 infection Results show persistent Interferon I signature and inflammasome activation long after recovery Read the news piece here 👇 carrerasresearch.org/en/news/sars-c… A bit more? CVID patients produce very few antibodies and, therefore, can not build a proper immune response. It is the most frequent primary immunodeficency and can affect up to 1 in 25.000 people. Persistent infections like COVID-19 help understand how CVID immune system reacts and might offer some clues on how to manage affected patients in the clinic. The research team included Dr. Roser Vento-Tormo @sangerinstitute and Dr. Klaus Warnatz @UniFreiburg Funding by @CaixaResearch Follow us for more! 👍

🚨 New paper alert 🚨 How do primary immunodeficient patients respond to SARS-CoV-2 🦠 infections? Find out what single-cell omic & spectral cytometry revealed in our latest #NatCommun article nature.com/articles/s4146…

The ggplot2 package has become so popular over the years that there are now over 100 extension packages specifically designed to enhance ggplot2 visualizations. These extensions make the ggplot2 syntax even more efficient and help create stunning graphs with ease. In the upcoming Statistics Globe online course, we’ll explore some of the most useful extensions. I’ve created dedicated course modules on the following: - geomtextpath: Combines text and paths for creative labeling along lines. - gganimate: Adds dynamic animations to your visualizations. - ggdist: Enhances visual representation of distributions and uncertainty. - gghighlight: Highlights specific data points or groups in your plots. - ggiraph: Makes your plots interactive with hover and click features. - ggpubr: Simplifies publication-ready plot creation with user-friendly functions. - ggrepel: Improves readability by preventing overlapping text labels. - ggstatsplot: Integrates statistical tests directly into your visualizations. - ggtext: Adds rich text formatting capabilities to your plots. - patchwork: Easily combines multiple plots into cohesive layouts. To give you a sneak peek of my favorite extensions, I’ve created a new YouTube video introducing my personal Top 5. Do you agree with my list? Let me know in the comments! Watch the video here: youtube.com/watch?v=44hTsl… Interested in diving deeper? Join the comprehensive Statistics Globe online course on Data Visualization in R Using ggplot2 & Friends, starting November 25. More information about the course: statisticsglobe.com/online-course-… Talk to you soon. Joachim #rstats #ggplot2 #dataviz #statistics #datascience

The immune response Credit: BigPicture & WellcomeTrust #MedEd #MedX #Immunity #Science #biology

Glad to have had the opportunity to collaborate with @CarrerasIJC and @GustaveRoussy on this exciting project! 🫶

Huge thanks to all who contributed: @angel_corbi, @crismunozp, @FGinhoux & @eballestar! 🙌 & more 🙌 #Epigenetics #Immunology #CancerResearch

Thrilled to announce that our study is now published in @ScienceAdvances! 🌟Together with @carlos_dlc_f and collaborators, we uncover how #NFκB & #TET2 drive #Macrophage reprogramming in #Hypoxia, challenging the notion that it is always immunosuppressive. bit.ly/4d8vlsN

🆕 Do not miss the latest study of @eballestar’s group, published at Science Advances (@ScienceMagazine)! 🔗 carrerasresearch.org/en/news/low-ox… The researchers have found evidence that low oxygen levels in tumours could actually enhance some of the body’s immune responses against #cancer, in contrast with the general paradigm that #hypoxia exclusively helps cancer progression.

Happy to share our study demonstrating that #NFκB & #TET2 promote #Macrophage reprogramming in #Hypoxia overriding #immunosuppressive effects of #TumorMicroenvironment @carlos_dlc_f & J. Calafell-Segura @CarrerasIJC w/ @angel_corbi & @crismunozp @FGinhoux science.org/doi/10.1126/sc…

🔥 Finally! Just launched the R color palette finder 🚀 🎨 Explore 2500+ palettes, see them in action, get the ggplot2 code. ➡️ r-graph-gallery.com/color-palette-… 🙏 @joseph_barbier and @Emil_Hvitfeldt for the paletteer package! Useful? Bug? Feature request? Let me know!