Carlo M. Cicala

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Carlo M. Cicala

Carlo M. Cicala

@carlomcicala

MD | Medical Oncologist | Sarcoma Translational Research @vhio | Doctoral Fellow @uabbarcelona | Soft spots: hiking, Russian books, long breakfasts.

Barcelona, Spain Katılım Ocak 2022
216 Takip Edilen148 Takipçiler
Marta Chiaravalli
Marta Chiaravalli@martachrvll·
🔥First-line chemotherapy regimens in #pancreaticcancer ✅ NALIRIFOX/FOLFIRINOX in fit patients ✅ Gemcitabine+nab-paclitaxel in unfit for triplets ‼️Four-drugs regimens (concomitant or sequential) are promising Our work hot off the press @theLancet kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…
The Lancet Oncology@TheLancetOncol

Online First: Comparison of first-line chemotherapy regimens in unresectable locally advanced or metastatic #pancreaticcancer: a systematic review and Bayesian network meta-analysis #pancsm thelancet.com/journals/lanon…

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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
Dr Kasper on the current landscape of treatment for #desmoid tumors: 🔸only sorafenib and nirogacestat are supported by RP3 trials 🔸choose less toxic agent first 🔸 tx duration still a matter of debate; 6-months reasonable window to assess efficacy #ESMOSarcomaAndRareCancers24
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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
📊 more on MDM2 inh #brigimadlin in #liposarcoma at #ESMOSarcomaAndRareCancers24 🔗 similar ORRs in DD and (exceptional!) WD-LPS (18.6/15%) 🔗 systemic tx in WDLPS has to be balanced with symptoms & QoL 🔍 how to decide? A role for MDM2 no. of copies? (➡️Bevill, Cell Genom 2023)
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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
“Difficoltà operative di gestione” -> Manganello indiscriminato. Che vergogna @poliziadistato @Piantedosim
Vitalba Azzollini@vitalbaa

Questo è il comunicato stampa della Polizia di Stato riguardo alle cariche agli studenti di Pisa e Firenze. Si motivano le manganellate con una presunta "tensione" causata dal fatto che a un certo punto il corteo avesse deviato rispetto al percorso concordato. Il comunicato è penoso. E lo è anche e soprattutto giuridicamente, perché comprova una reazione sproporzionata rispetto a un'azione di lieve entità. Ma soprattutto attesta che c'è chi dall'alto legittima condotte di tale e tanta violenza sui manifestanti. Gravissimo (per usare un eufemismo).

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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
I just would like to share how my country deals with unarmed teenagers manifesting for calling a ceasefire in Gaza. Of course, no policeman can be identified as no ID code is worn. I am truly horrified.
Giuseppe Conte@GiuseppeConteIT

Ancora una volta manganellate contro chi protesta per il massacro in corso a Gaza. Questa volta a Pisa, ai danni di studenti, giovanissimi. Altri episodi ci sono stati a Firenze. Sono immagini preoccupanti, non degne del nostro Paese. Non può essere questa la risposta dello Stato al dissenso.

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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
glad to present the first results of our study on the molecular characterization of #ESS at the #poster session at #CTOS2023 (it’s been relocated ! the original number was P388 😉) @VHIO @carisls
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Carlo M. Cicala@carlomcicala·
first data on BRD9 degrader FHD-609 in #synovialsarcoma at #CTOS2023 by @jalivingston_md. Effective degradation of target did not translate in meaningful activity. Chromatin remodeling complex remains an elusive and intricate drug target.
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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
#CTOS2023 has started with a tribute to Chris Fletcher, a giant in the field of #sarcomas, in this superb Convention Centre in Dublin 🇮🇪
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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
A #sarcoma made it to @NEJM! 📌 Nearly 40% ORR and long mDOR achieved by atezolizumab in #ASPS 📌 1st IO indication in sarcomas 📌 no ORR difference by previous TKI more research is needed to understand mechanism of response..and unresponsiveness! nejm.org/doi/full/10.10…
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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
🩸Hoy aquí, con mi medallita del #reptedor, participando en el Maratón de donación de plasma de @VHIO ! 🏅 Una horita de nuestro tiempo puede contribuir a salvar muchas vidas. ¡Animaos a donar! @donarsang
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WinetteVanDerGraaf
WinetteVanDerGraaf@Winette_vdGraaf·
Yesterday single arm study data on ipi-nivo in #desmoid were presented @ASCO2023 . Of course there was some effect radiologically: this is the nature of desmoid. 7/16 pts stopped bc of tox. Rationale for immunotherapy 0. It reminds me of a great book with very relevant title.
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Carlo M. Cicala
Carlo M. Cicala@carlomcicala·
honoured to having been a part in the birth of this international initiative for the advance on #patient reported-outcome in #sarcoma research & practice in the beautiful Amsterdam. Kudos for the great effort!
WinetteVanDerGraaf@Winette_vdGraaf

First day came to a close. Great presentations on development of #sarcoma PRO questionnaires on #TGCT @WTapMD & #desmoid by Mrinal Gounder and Anne-Rose Schut & TESS by Jay Wunder. Survivorship data by @OlgaHusson . Grateful to F. Pignatti for coming to reflect on EMA approach.

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Keşfet

@JCOPO_ASCO @quindos_maria @Genomicslab_ @DrCeSarcoma @dgomezpere @steland011 @Serrano_Lab @VHIO