@vijaypande Thanks Vijay! I hope all is well... we've had some folks reach out about testing the scaffold crystals so the publicity is working despite my dismal social media track record. : )
We built DNA scaffold crystals that can be reprogrammed to host different guest proteins for X-ray structure determination — no new crystallization screen required. This animation shows a guest protein (glowing) seeking its designed binding site inside the crystal lattice.
Full preprint on bioRxiv:
biorxiv.org/content/10.648…
We'd love to connect with groups working on DNA-binding proteins, structural biology platforms, or DNA nanotechnology — and we're especially interested in hearing from anyone whose target might be a good fit for this approach.