cengenproject

It was great to meet everyone involved in the @cengenproject yesterday! Photo by @xenopuselegans. Bonus: photo op with the Columbia bio dept gorilla 🦍. @barrett_alec @KrishnaswamyLab @AlexisWe @wormdoc1 @sethrtaylor @latinodeciencia @betenoire1 @AardvarkMarc

Finally out! Proud to present the collaborative effort where we systematically mapped neuropeptide-GPCR interactions biochemically (doi.org/10.1101/2022.1…) and constructed an in silico map of neuropeptide signaling in the worm brain doi.org/10.1101/2022.1…

The neuropeptidergic connectome of C. elegans biorxiv.org/cgi/content/sh… #bioRxiv

New tool available: you can now look at alternative splicing in many neuron types of the worm brain! Access it at splicing.cengen.org (1/7)

See the documentation at splicing.cengen.org for details on what the tools are showing. Please note that this data and tools are a work in progress, we are developing various ways to improve cleaning and validation. Feel free to contact us for questions or suggestions! 7/7

The event-level quantification, while harder to interpret, allows you to find interesting events across all neurons. The genome browser view gives direct access to the raw data and can help contextualize the results of the other tools. 6/7

Tired of seeing these "Disconnected from the server. Reload" error messages? We updated the CeNGEN scRNA-Seq app! (1/6)

As always, the code is on Github (github.com/cengenproject/…). Let us know if you still have problems, feedback, or if you need some more functionality! (6/6)

The new App is available at the previous URL (cengen.shinyapps.io/cengenApp). If you want to access the old App, it is still running and available at cengen.shinyapps.io/cengenApp-lega… (5/6)

Check out our new data release on the entire C. elegans nervous system!

4/4 Our manuscript is available at bioRxiv biorxiv.org/content/10.110… and data can be explored at cengen.shinyapps.io/CengenApp/.

3/4 More key findings: --cis-regulatory motifs for neuron-specific gene expression across the nervous system --Cell adhesion protein genes correlated with connectivity and process placement in the nerve ring

1/4 We are very excited to announce a gene expression data set for every neuron type in the entire C. elegans nervous system.