NSF Center for Genetically Encoded Materials

An exciting #NSFfunded discovery from the Miller Group and C-GEM!

✨ New C-GEM preprint E. coli ribosomes support translation of (R) and (S) β2-hydroxyacids in vitro: a structural and biochemical study Congrats @chon_majumdar, Alexandra, Noah, Cathy, Katie, Alanna, and Jamie! chemrxiv.org/engage/chemrxi… #NSFfunded #synbio

Want a digestible summary of our latest paper? Check out this great writeup by @ampepsoc americanpeptidesociety.org/aps-news/backb… #NSFfunded

✨New from C-GEM in @J_A_C_S: Peptide Backbone Editing via Post-Translational O to C Acyl Shift pubs.acs.org/doi/10.1021/ja… Congrats to @CarlySchissel and coauthors in the @schepartzlab and @GroupFrancis! #NSFfunded

Peptide Backbone Editing via Post-Translational O to C Acyl Shift | Journal of the American Chemical Society @AlannaSchepartz @cgem_cci @czbiohub @arcinstitute @UCBerkeley @UCB_Chemistry pubs.acs.org/doi/10.1021/ja…

✨ New from C-GEM in ACS Central Science: Thioesters Support Efficient Protein Biosynthesis by the Ribosome pubs.acs.org/doi/10.1021/ac… Congrats to Alexandra & Jacob, along with Isaac, Jess, @AlexSolivan, Noah, Katie, Alanna, Jamie, and Scott! #NSFfunded

Are you an undergrad graduate (or soon to be) from an underrepresented background seeking research experience to place into a PhD program? A post-bacc experience at Yale, fully funded, can make you a competitive applicant. Learn more and apply by 2/28. bit.ly/ChemYalePREP

✨ New from C-GEM on @biorxivpreprint Monitoring monomer-specific acyl-tRNA levels in cells with PARTI Congrats Meghan, @CarlySchissel, Izzy, Cameron, and @schepartzlab! #NSFfunded #RNA biorxiv.org/content/10.110…

#NewNProt: A direct and quantitative assay to monitor the activity of #aminoacyltRNAsynthetase (aaRS) enzymes by using intact #tRNA LC-MS bit.ly/42myeVt @cgem_cci, an @NSF Center for Chemical Innovation #MassSpec

✨ New from C-GEM in @NatureProtocols: nature.com/articles/s4159… This intact tRNA acylation assay discriminates acyl from non-acyl-tRNA, identifies rare acyl-tRNA species, and can quantify low-yield reactions. Congrats Riley, Cameron, Isaac, Sarah, @schepartzlab! #NSFfunded

Thoroughly enjoyed sharing my research on engineering aminoacyl-tRNA synthetases without relying on ribosomal translation, published earlier this year. Thank you Prof. Ruchi Anand (@ruchianand1975 ) and @Chemistry_IITB for hosting me!

📰 Hot off the press at @NatureComms: RNA language models predict mutations that improve RNA function nature.com/articles/s4146… Congrats to @shulgina_kate and coauthors on a great C-GEM + @igisci collaboration! #NSFfunded #RNA #MachineLearning

✨ The latest from C-GEM on @biorxivpreprint Structure of an Archaeal Ribosome with a Divergent Active Site biorxiv.org/content/10.110… Congrats to Amos, @shulgina_kate, Roan, Jamie, and collaborators on a great story! #NSFfunded #ribosome

Shoutout Isaac Garcia, current @cgem_cci postbacc in the @schepartzlab!!!

Read about the activity here: gem-net.net/celebrate-nati…

🍝 It’s #NationalPastaDay! We use pasta to teach how monomer sequence and shape controls the final structure and, therefore, potential functions of a polymer. Download the at-home guide: airtable.com/app5gpXf6rpXK1…

Congrats, Alex!!

✨New from C-GEM: Role of ribosomal protein bS1 in orthogonal mRNA start codon selection Congrats to @kristina_vboyko, her undergrad mentees Rebecca and Minji, and @cate_lab! biorxiv.org/content/10.110…

Check out our work on introducing thioesters into ribosomal bond formation! It's been a super awesome experience being part of such an interdisciplinary project and super excited to finally see it live on @ChemRxiv!

✨ New C-GEM preprint: Thioesters support efficient protein biosynthesis by the ribosome chemrxiv.org/engage/chemrxi… Congrats to the dream team of @anyadkent & @JacobGRobins + collaborators Isaac, Jess, @AlexSolivan, @NoahXHamlish, Katie, @AlannaSchepartz @MillerGroupYale @cate_lab