Charles Warren

@JacobGeri1 @sp3intermediate @AlexSolivan More protein input too could help (we kept the scale the same for the comparison)

@sp3intermediate @AlexSolivan We tried that with dasatinib, but the signal was 100x lower. May be possible with a better MS or a more potent diazirine conjugate.

I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces. biorxiv.org/content/10.110…

@Sculpturatus Puberty hit Kaos HARD

handsome dog

Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova @katenokv and colleagues at @RockefellerUniv @TPCB_NYC @WeillCornell @MSKCancerCenter @scrippsresearch dlvr.it/THQfxm

Online now! Covalent targeting of splicing in T cells by Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Ekaterina V. Vinogradova @katenokv and colleagues at @RockefellerUniv @TPCB_NYC @WeillCornell @MSKCancerCenter @scrippsresearch dlvr.it/TGR63y #chembiol

Happy to share this work from my rotation in @katenokv ‘s lab! This was my first experience preparing proteomic samples and a deep dive into the power of cysteine ABPP to discover new biology. Thank you to everyone who helped bring this together!

Excited to see the final version of our manuscript out in @CellChemBiol! In this study, we investigate the mechanism of action of an immunosuppressive small-molecule electrophile, which targets a core splicing factor SF3B1! @RockefellerUniv authors.elsevier.com/a/1k9mh8jWWJxM…

Gotta love the restricted access irony

@Sculpturatus Don’t complain! We may not get more….

dude it was just weekend, how is it weekend again already

@OrgBiomolChem was delighted to sponsor such a wonderful event and a big congratulations to Charles Warren @chardw98 from the @JacobGeri1 lab at @WeillCornell for winning the OBC poster prize!🎉

@Sculpturatus Most *chaotic* (;

@BobbyHollings I aim to increase the rigor in the field!

@chardw98 Wait until you do a deep dive on that paper: x.com/BobbyHollings/…

Changing my thesis research

Super excited to see my most recent work (and first paper!) from the @KapoorLab_RU online @J_A_C_S! By taking advantage of electrophilic 'scout fragments', we identify allosteric inhibitors of helicases, enzymes that have been challenging to target. pubs.acs.org/doi/epdf/10.10…

Very excited to share our new @biorxivpreprint! Big thanks to all the co-authors who contributed to this story on Covalent targeting of splicing in T cells! @Sculpturatus, Hiro, Nathalie, @chardw98 @teezhangg @xzhang85 Read more below!

God have mercy

@TheRedinboLab @CellChemBiol Awesome work! @ManderzzG

Go check out our paper on tryptophanases released in @CellChemBiol!! Exciting work driven by senior graduate student Amanda Graboski! cell.com/cell-chemical-…

The Geri Lab is recruiting postdoctoral scholars to develop photocatalytic proximity labeling and proteomics technologies. Chemical biologists and chemists who want to learn chemical biology are welcome! gerilab.weill.cornell.edu/team The view from our recently expanded NYC lab space:

Doubleheader in JACS! An awesome collaboration with @Merck on leveraging μMap toward the mapping of protein binding sites. Congrats @HuthSean @HuthSean, James, @CiaranSeath, @JacobGeri1, Aaron, and the whole team at Merck! pubs.acs.org/doi/abs/10.102…