Cjay Chege

Just published my new ERC proposal: Protocol Control Disclosure Core. A minimal graph-native standard that makes “who controls what” in DeFi protocols machine-readable and transparent. Full post here → @0x0afe5e054249b19ae29075540d9e6951c66e49b7/protocol-control-disclosure-core-making-who-controls-what-machine-readable-on-ethereum" target="_blank" rel="nofollow noopener">paragraph.com/@0x0afe5e05424…

@JonhernandezIA People are Universal Explainers, anything that can be understood we can understand it! And there can never be entities that are more universal than others.

“Discovery may become the job of AI. Understanding remains ours.” Sam Altman says biology may be too complex for humans to discover alone. A smarter system could solve what we can’t, then explain it in a way we can understand.

Sam Altman just revealed he put his ENTIRE liquid net worth into one company to reverse aging. The company is called Retro Biosciences. He put $180 million of his own money as the seed round. Then he came back for a $1 billion Series A. The company is now valued at $5 billion. Here's what they're building: Retro is working on something called partial cellular reprogramming. The basic idea is that your cells can be rewound to a younger state without turning them all the way back into stem cells. You stay you, but your biology gets younger. Most diseases are diseases of age. 20yo rarely get sick the way 80yo do. So instead of fighting cancer, Alzheimer's, and heart disease one by one, what if you just made the cells younger so those diseases never develop in the first place? That's the bet. One solution that cuts through EVERYTHING. And here's where AI enters the picture: OpenAI built a specialized model called GPT-4b micro specifically for Retro's research. They used it to redesign the proteins responsible for turning adult cells back into stem cells, a technique that won the Nobel Prize when it was first discovered. The original method was painfully slow. Worked on fewer than 1 in 1,000 cells. OpenAI's AI-designed proteins made the process 50 TIMES more efficient. Cells that used to take 3 weeks to reprogram were doing it in 7 days. And the AI came up with protein modifications so radical that human scientists would never have tried them, some differing by over 100 amino acids from the originals. Altman said AI compressed years of biological research into a fraction of the time. Retro's CEO said the model delivered results faster and better than any human-led effort they'd attempted. They've already started human trials for a drug targeting Alzheimer's. But here's the part that should make everyone stop and think... Altman also revealed that GPT-5 was specifically upgraded to handle healthcare queries. People are already uploading their medical records, asking about symptoms, and getting real answers. He told a story about taking a picture of a skin issue and ChatGPT correctly diagnosing it and offering to prescribe medication on the spot. Doctors at hospitals across the country are secretly using it at home because their workplaces don't have HIPAA-compliant versions yet. Every clinic he visits tells him the same thing: Every doctor here uses ChatGPT, they just can't admit it publicly. His prediction is that within 10 years, every person on Earth will have access to BETTER healthcare than the best healthcare anyone can get today. Think about this for a second... The CEO of the world's most powerful AI company put every dollar he had into an anti-aging startup. Then he built a custom AI model exclusively for that startup's research. That model produced results 50x better than anything humans achieved. And simultaneously his main product is being quietly adopted by the entire medical profession without official approval. OpenAI is becoming the backbone of a healthcare revolution that most people haven't even noticed is underway. The billionaire longevity race used to be an irrelevant sidequest. Bezos put some into Altos Labs. Zuckerberg and Thiel backed similar ventures. Nothing serious. But Altman's approach is different because he has something none of them had: An AI capable of doing the actual science faster than human researchers ever could. If Retro's cellular reprogramming works at scale, the first generation of people who get to live significantly healthier and longer lives might already be alive today. And Altman is barely talking about it, I wonder why.

[The rationalist] seeks not to convince but to arouse — to challenge others to form free opinions. — Karl Popper

chatgpt has gotten soooo much better with the latest update. really proud of the team for this one.

“We live in the age of nonlinear returns. So there’s no point in fighting over the small pie before it’s fully baked, especially in the tech business.” — @naval

Understanding is one of the higher functions of the human mind and brain, and a unique one. @DavidDeutschOxf

@philosophymeme0 Poper solved epistemology!

AI helps you decrease the time between idea and execution,for the first time you can get instant feedback on your ideas 💡

Sophisticated foods are bittersweet (wine, beer, coffee, chocolate). Addictive relationships are cooperative and competitive. Work becomes flow at the limits of ability. The flavor of life is on the edge. @naval

The secret to public speaking is to speak as if you were alone. @naval

The tools for learning are abundant. It’s the desire to learn that’s scarce. @naval

It’s called a rocket ship.

Saylor be like..

@EtherealnewsHQ @brienthunter @z0r0zzz @0xndavd @boredGenius ERC-8241 is trying to standardize something Ethereum surprisingly still lacks: a canonical machine-readable way to describe protocol control structure “who controls what” is fragmented across docs, multisigs, timelocks, governance forums, proxy admins, bridge configs and audits.

New podcast on sales is up! Sell the Truth. - Defining charisma - The case against sales tactics - Why you don’t need frameworks - Walking away from bad deals - Living several lives in one life 00:00 Be Credible 03:18 “Yes, And” 04:31 Selfish Honesty 05:37 Charisma Is Confidence + Love 07:56 Don’t Manage, Lead 11:16 Hunt Together 14:51 Feed Your (Good) Obsessions 18:57 Sell the Truth 21:07 Good Deal or No Deal 23:39 The Age of Nonlinear Returns

Executive Brief of our latest episode: Sell the Truth 1.⁠ Credibility matters more than sales tactics. The people worth impressing can see through manipulation immediately, so persuasion starts with authenticity, competence, and honesty. 2.⁠ Saying “yes, and” works because most people have a reason for believing what they believe. Understand their position first before trying to move them anywhere else. 3.⁠ Objectivity is a form of honesty. The more ego you remove from your thinking, the more clearly you can see reality and make better decisions. 4.⁠ Charisma is confidence plus love: projecting strength and goodwill at the same time. Honesty without kindness turns people away; kindness without honesty becomes fake. 5.⁠ Leadership is not telling people what to do—it’s making them want to do it. The best leaders connect the mission to people’s own ambitions and motivations. 6.⁠ Humans are built to hunt together in small, high-trust groups. The most meaningful work happens when small teams of highly capable people pursue difficult missions together. 7.⁠ Sales works best when it doesn’t feel like sales. If you genuinely believe in what you’re offering, enthusiasm replaces technique. 8.⁠ Feed your good obsessions. Real work is driven more by obsession, curiosity, and intrinsic motivation than by frameworks, business books, or motivational podcasts. 9.⁠ Optionality matters. The wrong long-term deal can trap you for years, so it’s better to walk away than compromise into the wrong partnership. 10.⁠ We live in an age of nonlinear returns. One massive outcome outweighs dozens of smaller wins, so focus on asymmetric upside instead of fighting over small spoils. 11.⁠ The goal is not to maximize every dollar—it’s to build a life where you preserve your freedom, energy, curiosity, and peace of mind.

Without error-correction all information processing, and hence all knowledge-creation, is necessarily bounded. Error-correction is the beginning of infinity. @DavidDeutschOxf