Srinivas
15 posts


🧵 Clinical Pearl
Paradoxical Mantoux = A previously negative Mantoux test becomes positive after initiation of anti-tubercular therapy.
Mechanism:
Active TB → anergy → effective ATT restores cell-mediated immunity → delayed hypersensitivity returns → Mantoux (+)
Key point:
✅ Immune recovery
❌ Not treatment failure
Seen in:
• Miliary TB
• TB meningitis
• Malnutrition
• Immunosuppression
#Tuberculosis #MedTwitter @docakx @IhabFathiSulima #Rheumatology #ClinicalPearls

Aravind Palraj@Rheumat_Aravind
Choosing between Mantoux (TST) and IGRA matters. BCG-vaccinated adults? → IGRA is usually the better, more specific test. Limited access? → TST is still acceptable. Don’t use both routinely - pick the right test for the right patient. #Rheumatology #MedTwitter #TB #Tuberculosis #IGRA #Mantoux @DrAkhilX @IhabFathiSulima #InfectiousDisease #ClinicalPearls #DoctorTwitter #IndiaHealth #MedicalEducation
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6️⃣ Eyes
Examine:
Conjunctiva → pallor
Sclera → jaundice
Cornea → Kayser-Fleischer ring
Pupils
Nystagmus
Fundoscopy if needed
7️⃣ Mouth & Tongue
Look for:
Central cyanosis
Oral ulcers
Angular stomatitis
Glossitis
Poor dentition
Candidiasis
Dehydration
Fetor hepaticus
Gum hypertrophy
Tongue clues:
Smooth → B12 deficiency
Tremulous → thyrotoxicosis
Dry → dehydration
8️⃣ Neck Examination
Neck Veins
JVP
Lymph Nodes
Always check:
Cervical
Axillary
Inguinal
Thyroid Examination
Enlargement
Nodules
Tenderness
Carotids
Bruits if indicated
9️⃣ Chest & Skin
Look for:
Scars
Rashes
Pigmentation
Spider nevi
Petechiae
Purpura
Striae
Edema
Pressure sores
🔟 Lower Limbs
Check:
Pedal edema
Cyanosis
Varicose veins
Ulcers
Calf tenderness
Peripheral pulses
1️⃣1️⃣ Anthropometry (When Relevant)
BMI
Waist circumference
Mid-arm circumference
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General Physical Examination (GPE) Scheme for Residents & House Officers
[This Is the Scheme I Follow as a
Resident]
A structured GPE is not just a ritual, it often gives the diagnosis before investigations arrive.
1️⃣ Start From the End of Bed
Before touching the patient, observe:
Sick or comfortable?
Conscious level
Body build & nutritional status
Posture & gait
Respiratory distress?
Pallor / jaundice visible?
IV lines, catheters, oxygen, drains
Abnormal movements
Facial appearance (Cushingoid, acromegaly, Parkinsonian, myxedema etc.)
This “end-of-bed impression” is highly underrated.
2️⃣ Vital Signs (Never Skip)
Pulse
Rate
Rhythm
Volume
Character
Radio-radial delay
Radio-femoral delay
Blood Pressure
Both arms if indicated
Postural BP if dizziness/syncope
Respiratory Rate
One of the most ignored yet most important vitals.
Temperature
Pattern matters.
Oxygen Saturation
3️⃣ General Survey
Build & Nutrition
Cachexia
Obesity
Muscle wasting
Dehydration
Mental Status
Orientation
Agitation
Confusion
Drowsiness
Hydration Status
Look for:
Dry mucosa
Sunken eyes
Poor skin turgor
Hypotension
4️⃣ Hands Examination
Look at:
Pallor
Cyanosis
Clubbing
Koilonychia
Leukonychia
Nicotine staining
Tremors
Flapping tremor (asterixis)
Peripheral cyanosis
Dupuytren contracture
Osler nodes / Janeway lesions
Capillary refill
Palms may diagnose:
Liver disease
Endocarditis
Thyrotoxicosis
Chronic hypoxia
5️⃣ Face Examination
Look for:
Pallor
Jaundice
Cyanosis
Facial puffiness
Malar rash
Butterfly rash
Moon face
Mask facies
Ptosis
Exophthalmos
Xanthelasma
Facial asymmetry
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EASY ONE 🔥🔥EMERGENCY 🔥🔥
Newborn with respiratory distress and sudden deterioration.
Chest X-ray done
Spot the special sign.
What is your diagnosis ?
#MedX image courtesy ;

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BIG BREAKING NEWS 🚨 MASSIVE 50% Biharis have voted for BJP in Delhi 🔥🔥
Next Election is in Bihar !!
Record 40% South Indians voted for BJP as per Axis My India. MASSIVE improvement after Annamalai campaigned here.
54% Haryanvis and 57% Pahadi voters of Uttarakhand and Himachal respectively backed BJP 🔥


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@RShivshankar Another Pakistan in making!
Can't say God save Canada , as HE too is fed up with their pruile antics
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Shocking! Canada state broadcaster (CBC) mainstreams a Xenophobe, religious exclusivist like Pannu to incite hate attacks against Hindu-Canadians calling into question their loyalty to Canada and suggesting that they should be expelled.
A state broadcaster can't be acting on its own.
This is nothing but the Canadian state sponsoring hate and extremism!


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@CYBTRAFFIC Sir, Was issued double challan for the same violation at the same time in Cyberabad jurisdiction. Called the numbers in website but getting re-directed to call multiple personal numbers without any solution. Please help in resolving the issue. Thank you.
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@balaji25_t Thank you Sir for your efforts to keep us updated. Appreciate your untiring dedication and concern towards the people of TS in general and Hyderabad in particular. You deserve all round applause for it.
Have a wonderful day!
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Widespread rains occured in North Telangana during overnight hours
ALERT ⚠️
The depression impact to turn massive as widespread downpours ahead in North, East, Central Telangana during next 72hrs with FLOODS expected at few areas ⚠️
Hyderabad asusual we'll have moderate rains, gloomy ముసురు kind of weather these 72hrs
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@TimesAlgebraIND We decide our foreign policy as per our needs and requirements. Can not be to the interest of a third party which never supported India in any international forms
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🚨 Ukrainian President Zelensky criticises PM Modi.
He said "Its a huge disappointment that leader of World's largest democracy hugs bl00dy criminaI in Moscow"
Zelensky didn't like PM Narendra Modi meeting Russian President Vladimir Putin in Moscow.
"This is a devastating blow to peace efforts" - He said


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