Christopher Frøhlich 🇪🇺🇳🇴🇨🇦🇩🇪🏳️‍🌈

Are you interested how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis nature.com/articles/s4192…

🚨PREPRINT🚨 Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬. #OXA48 #ceftazidime #enzymeevolution biorxiv.org/content/10.648…

Living in the Arctic 🥶 means Christmas comes early 🎁🥳 10 MNOK (≈1 MUSD) Early Career Investigator grant from the Research Council of Norway to work with the fabulous @AdrianBunzel (Max Planck Institute) on uncovering the molecular mechanisms of antibiotic resistance. #AMR

Happy to share our recent manuscript published in @PNAS from @tokuriki_lab @utnk1 ! Our bioinformatic analyses reveal an important and overlooked role of alkaline phosphatase, a common cloning enzyme, in phosphite metabolism. pnas.org/doi/10.1073/pn…

Interested in β-lactamase inhibitors? 🧪 Our new mSphere paper shows how a covalent boronic-acid + chelator fusion ⚗️ can restore β-lactam susceptibility in metallo-β-lactamase producers, even in variants that are difficult to inhibit with taniborbactam. journals.asm.org/doi/full/10.11…

Is it too early for a year review? 🤔 Research stays at ETH Zürich with Adrian Bunzel and at UBC Vancouver with Nobu 🤓. Now I’m moving labs to start as Associate Professor at UiT, which means organising freezer contents 📦. Two preprints coming soon 🧬. Stay tuned!

This account beat me to it… a very talented HFSP postdoc with me (John Chen no twitter) has developed a hierarchical clustering method that overcomes many of the issues with traditional seq similarity networks.

Awesome having @_karolbuda from the @tokuriki_lab visiting @UiTNorgesarktis. 🍺 for the next round of collaboration!

@hammerjeanet presenting how Marine Biochemistry can help to fight cancer and AMR at #Febs2024 @UiTNorgesarktis

🔬 Thrilled to have presented our research at #FEBS2024! 🧬Mutations can shift the rate-limiting steps in enzyme reactions during evolution, creating strong synergistic effects. 🙏Thanks to everyone for participating and all the positive engagement! doi.org/10.1038/s41929…

🌟 Feeling incredibly grateful today as I've been awarded the #EarlyCareerScientistAward by @UiTNorgesarktis. Huge thanks to everyone who's guided, supported, and inspired me along this path. Here's to more research, and collaboration. #EarlyCareerAward #Science #UiT

🚨β-lactamase expression induces collateral sensitivity in Escherichia coli🚨 Our new paper, spearheaded by the great @Cris_Herencias and @Lauralvllo, has been published in @NatureComms!!! Great to see this collab with the fantastic @AlvSanMillan out!! nature.com/articles/s4146…

For the Norwegian crowd: Oppdag hvordan små genetiske endringer i bakterielle enzymer kan føre til stor antibiotikaresistens. Lær om det fascinerende fenomenet epistase og dets betydning for utvikling av fremtidige medisiner. 🦠🔬 forskersonen.no/antibiotikares…

How will the inclusion a microbial species change the function of a community? How will the acquisition of a specific mutation change the phenotype of an organism? Both questions can be addressed using a same quantitative framework. Find out more: doi.org/10.1016/j.cell…

🌍 Team up with @chrfrohlich and me to tackle antimicrobial resistance! Apply with us for an #HFSP Postdoctoral Fellowship to combat #AMR with #deeplearning, #proteindesign, and #directedevolution.🧬🔬 hfsp.org/funding/hfsp-f…🌟 #ScienceFunding #Postdoc @ETH_BSSE @UiTNorgesarktis

Our exciting collaboration with the great @tokuriki_lab on the biophysical basis for the malleability of trait correlation in single proteins (YFP and VIM2 metallo-β-lactamase) and on short evolutionary time scales. nature.com/articles/s4146…

Antimicrobial resistance may evolve more rapidly than previously thought | In a study in @NatureCatalysis, a team led by @AdrianBunzel @BPL_ethz and @chrfrohlich @UiTNorgesarktis revealed a novel mechanism for how resistances can emerge alarmingly fast >u.ethz.ch/fNMrR

Biocatalysts make chemical industry more sustainable but engineering enzymes is too slow! Check out our preprint @hollfelderlab where we show how microfluidics & AI can help: We rapidly sequence-function profile an IRED in microdroplets and use AI to accelerate its engineering⚡️

🚨paper alert🚨 #Epistasis makes combining mutations unpredictable.🤷 This complicates #enzymedesign and predicting the effect of mutations.⁉️ Through in-depth evolutionary analysis, we recently uncovered an underappreciated mechanism for epistasis.🧬♻️🔍 nature.com/articles/s4192…

Are you ready to push the boundaries of #LifeSciences? #HFSPFellowship Program is now accepting Letters of Intent. Learn about the LTF and CDF fellowships for PhD researchers at bit.ly/3ZMPQp0🔍Dive into a new area of study and work in a new country! #ResearchOpportunity

Still time to apply and register for NordBio II - Nordic Midsummer Symposium on Biocatalysis, 13-14 June 24! sites.google.com/view/nordbio-2…