Morito Sakuma

82 posts

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Morito Sakuma

Morito Sakuma

@MSakuma8

Assistant Professor in Kyoto University/Evolution/Enzyme/Single molecule measurement/Microfluidics/Bioinformatics

Katılım Mart 2019
280 Takip Edilen126 Takipçiler
Morito Sakuma retweetledi
Tokuriki lab
Tokuriki lab@tokuriki_lab·
Excited to see our latest manuscript is out @PNAS. It shows a potential role of alkaline phosphatase (AP) in a global phosphite metabolism. It is a great piece of work from @MSakuma8 in collaboration with @utnk1. pnas.org/doi/10.1073/pn…
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Morito Sakuma retweetledi
Naoki Konno
Naoki Konno@utnk1·
Thrilled to see this manuscript now published in @PNASNews! Congratulations to @MSakuma8 and everyone in the @tokuriki_lab team. I’m truly grateful for the opportunity to contribute, particularly to the comparative genomics analyses. pnas.org/doi/10.1073/pn…
Morito Sakuma@MSakuma8

Happy to share our recent manuscript published in @PNAS from @tokuriki_lab @utnk1 ! Our bioinformatic analyses reveal an important and overlooked role of alkaline phosphatase, a common cloning enzyme, in phosphite metabolism. pnas.org/doi/10.1073/pn…

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Morito Sakuma retweetledi
Tokuriki lab
Tokuriki lab@tokuriki_lab·
Our new perspective paper, led by Sevan Gholipour and Dongkyu Lee, is out @BiochemistryACS. We discussed molecular evolution and origins of antibiotic resistance genes" It is interesting to think how ARG evolved against natural vs synthetic antibiotics. pubs.acs.org/doi/10.1021/ac…
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Naoki Konno
Naoki Konno@utnk1·
Excited to share a new preprint! We've discovered repeated evolution of protein 3D structure in recurrently emerged bacterial ALDH-ADH fusion enzymes. Repeatability of protein structural evolution following convergent gene fusions biorxiv.org/content/10.110…
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Tokuriki lab
Tokuriki lab@tokuriki_lab·
Our latest manuscript "Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning" is out @NatureComms It is a great collaboration with Francesco Zamponi and Martin Weigt! nature.com/articles/s4146…
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Morito Sakuma retweetledi
Tokuriki lab
Tokuriki lab@tokuriki_lab·
Excited to share our new preprint! We have done a comprehensive bioinformatic analysis of β-lactamases (all major five classes together). The work pretty much repaints our understanding of how β-lactamases are distributed in the environments. biorxiv.org/content/10.110…
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Morito Sakuma retweetledi
Tokuriki lab
Tokuriki lab@tokuriki_lab·
Happy to share our new manuscript "Measuring differential fitness costs and interactions between genetic cassettes using fluorescent spectrophotometry". We developed a nice and easy way to determine fitness differences using a fluorescent plate reader. journals.asm.org/doi/10.1128/ae…
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Morito Sakuma retweetledi
Tokuriki lab
Tokuriki lab@tokuriki_lab·
We found my father! He seemed to fall down yesterday and hospitalized. He is well now. Thank the person who helped him, VPD and you all!
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Ayşe Nisan Erdoğan
Ayşe Nisan Erdoğan@erdogananisan·
So excited to get to share the preprint of our work (also my very first research article!) at the @tokuriki_lab demonstrating that evolution under static selection pressures can promote functional diversity, and thus population-level evolvability, in proteins.
Pouria Dasmeh@PouriaDasmeh

Thrilled to share our latest preprint collab with the amazing Tokuriki Lab (@tokuriki_lab) and the lead author, Ayse (@erdogananisan)! We explain how the combination of neutral drift & threshold selection maintains phenotypic variation. biorxiv.org/content/10.110…

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Morito Sakuma retweetledi
Tokuriki lab
Tokuriki lab@tokuriki_lab·
Happy to share our recent preprint "Neutral Drift and Threshold Selection Promote Phenotypic Variation". This work touches on a profound question of how "phenotypic variation" can arise from evolutionary drift in a simple and static environment. biorxiv.org/content/10.110…
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Morito Sakuma
Morito Sakuma@MSakuma8·
@akg_entrance ありがとです！表紙落ちお蔵入りが表に出て良かったです。笑
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Keşfet

@pnas @utnk1 @PNASNews @tokuriki_lab @BiochemistryACS @NatureComms @PaolaLaurino @OISTedu