Clayton Bingham, PhD

Workshop opportunity! Interested in using neural stimulation & brain recordings to understand brain function? Register for this #BRAINInitiative 2-day virtual workshop, exploring progress made, challenges to overcome, & potential impact. #studyBRAIN go.nih.gov/rBavITh

Reduced Thalamic Excitation to Motor Cortical Pyramidal Tract Neurons in a Mouse Model of Parkinsonism “reduced motor cortical outputs in PD are an immediate consequence of basal ganglia inhibition but also involves local circuitry adaptations within M1” biorxiv.org/content/10.110…

Bad title, good article. At the end of the day, one problem is easier than three & small topics are easier than large. Reality: Too many “day one” trainees think they should shake up a group with a flurry of new ideas. Unlikely as it is unproductive. insidehighered.com/advice/2022/09…

@iProgress_CC @RichCompNeuro @OpenAcademics @AcademicChatter …I forgot how hard it is to have protected time in the office. As much as I love spontaneous science chats and camaraderie, oof, it’s easier to buckle down and finish stuff away from the door knocks and shoulder taps.

@RichCompNeuro @OpenAcademics @AcademicChatter I’ve been enjoying the lightbulb moments - but also noticing a lot of time being spent on water cooler conversations, which eats up a lot of time. Will be interesting to compare stats on productivity and mental health 2 years down the line.

I'm torn, #AcademicTwitter @OpenAcademics @AcademicChatter. There's some pressure to return to the office, and I agree it's probably time. But I have a great WFH routine, and there's nothing I NEED to do in the office. I imagine I'll split the difference somehow. Thoughts?

@AcademicChatter Don’t trust those who tell you “PhD isn’t a race”

What's your single best tip for new starting PhD students?

@LisaRGibson @Melterialsgal If it were, would it be such a bad thing?

@bradpwyble @yael_niv @ashleyruba Not acknowledging the toxicity of, “still I don't charge them tuition”, is concerning Do you have industry exp in a “typical” job? (none in CV) I have & I disagree that PI job difficulty or investment in employees is greater than for major Corp managers Let’s stop here 🫠

@UnreadableP @yael_niv @ashleyruba The market doesn’t (strongly) determine postdoc salary and postdocs are actually difficult to recruit science.org/content/articl…

@yael_niv @ashleyruba The implication then…equally shocking.

@claytonsbingham @ashleyruba I didn't say that at any point. You did.

@yael_niv @ashleyruba The suggestion that postdocs should be grateful they aren’t paying you to work for you is shocking. I don’t know you, personally…so, I’ll say that, generally, the belief that profs are something like god’s gift to their students/postdocs is not a good look.

@claytonsbingham @ashleyruba No, training with me is so valuable because I put in my all to make sure they learn what they want to learn and experience what they want to get experience with, regardless of what my grants fund us to do, and still I don't charge them tuition but rather I pay them. How bout that

@yael_niv @ashleyruba So, your postdocs are valuable because their ideas are so good that you don’t need to tell them what to do, but you still think they only merit trainee status/pay? Many companies consider their employees trainees for bigger roles without undervaluing them in their current one.

@ashleyruba Not justifying the low salary (and I pay my postdocs somewhat, but not a lot more), but a reminder that a postdoc is still a training position. I don't tell my postdocs what to do, but rather we are driven by what they need and want to do. That's not always the case in industry.

@Bluefishdude @sofiavanmoorsel About half of the 50k US postdocs will try to cram themselves into those 50 tweets.

Pilot study of responsive nucleus accumbens (NA) deep brain stimulation for loss-of-control eating “[When] the device sensed NA signals that had been found to predict food cravings, it automatically stimulated that region, disrupting the craving signals” nature.com/articles/s4159…

“We developed Comprehensive Analysis of Tissues across Scales (CATS),…to densely map brain tissue architecture from millimeter regional to nanoscopic synaptic scales in diverse chemically fixed brain preparations, including rodent and human” biorxiv.org/content/10.110…

@RichCompNeuro @AcademicChatter @OpenAcademics Sounds like someone is gearing up for faculty search season…me too! Care to swap?

It will never cease to amaze me how much rewriting, revision, and editing a mere 3500 character research statement requires. @AcademicChatter @OpenAcademics #AcademicTwitter

Bonus methods insight: these conclusions were not possible without realistic branching near sites of stimulation...this anatomical detail cannot be captured with dwMRI-tractography alone. Generative methods provide a means of combining invasive and non-invasive neuroanatomy. 6/6

Thus, cortical EPs currently being used as evidence of HDP activity are likely highly contaminated by direct recruitment of capsular fibers, many of which may not bear collaterals to the STN at all! 5/6

It's time for me to explain what this paper was about: Activation of the hyperdirect pathway (HDP) is thought to be one therapeutic mechanism of subthalamic DBS, and many have assumed HDP activity can readily be observed in fast cortical evoked potentials! 1/5