The Ho Lab

The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation biorxiv.org/content/10.110…

Happy to share our new review of kainate receptor structure and gating. @shantigangwar @MariaKarela3 @LauraYen42 frontiersin.org/journals/pharm…

Learn how our hunt for the native structure of top #antimalarial target PfATP4🧂led to the discovery of PfABP, an unknown essential binding partner, out now! @natcomms 👉 rdcu.be/eLRlH 🦠🔬❄️ A team effort by @mehsehret @cmholab & Anurag Shukla @AkhilVaidya1 #cryoEM

Great work from @YueJianUSTC @YaleMicroPath @YaleMed in @PNASNews #Legionella #T4SS pnas.org/doi/10.1073/pn…

New online! Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting bit.ly/4n7AJC4

Structures of kainate receptor channel GluK2 in the apo closed and open conducting states, both with 2-fold symmetrical LBD layer. To open the channel, we used agonist kainate and positive allosteric modulator BPAM but no Concanavalin A! @shantigangwar nature.com/articles/s4159…

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @NatureSMB🥳rdcu.be/eBbrH Massive team effort led by @leonie_anton @mehsehret @Wenjing_Cheng_ in collaboration with @DziekanJerzy @CowmanAlan #teamtomo

Thank you so much @hypothesisfund and @Yeh_Lab for supporting us in this new venture!! We're excited to get started! 🦠🔬❄️

3/ Awardee @mimi1inh tackles the complex challenges of protein sequencing by leveraging molecular machinery made by microbes. Her work could revolutionize how we study protein function + structure, & our understanding of biology🤯. 🥳Congrats Dr. Ho! @Columbia 🙏#HFScout @Yeh_Lab

🌠 We're thrilled to announce our latest @HypothesisFund awardees and their groundbreaking projects! From optimizing enzymes, to protein sequencing, and membrane 'functional hotspots', each of these projects holds the potential to be broadly transformative for science! 1/ 🧵

Endogenous structure of antimalarial target PfATP4 reveals new class of apicomplexan P-type ATPase modulators biorxiv.org/content/10.110… #biorxiv_micrbio

Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥 Thrilled to present part 2 of my postdoctoral work with @NogalesLab @CollinsRNPLab @berkeleyMCB where we investigate this using #CryoEM and transgene insertion in 🧪 and cells!

The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.110…

Love when Malaria gets a MOM shoutout! pdb101.rcsb.org/motm/299 @LlinasLab @mimi1inh

So excited to be joining the Pew Scholar family! Thank you @pewtrusts for supporting and believing in our vision and congrats to the 2024 class of scholars!!! 😊 pew.org/3KXaxJr

We have a fully-funded postdoc position in the @cmholab in #NYC to study how #membraneproteins drive host-pathogen interactions in #malaria parasites using #CryoEM and #CryoET!🦠❄️🔬Email chi-min.ho@columbia.edu with your CV to apply! tinyurl.com/5n96rkfm #teamtomo

We're back! Together with #MPM/#KMCB, we are holding a Young Investigators in Parasitology Meeting (YIPs) for junior PIs! We'll have panels & group discussions on all things to do with starting a new lab. Register here!👇👉tinyurl.com/mr22ahrm

We'll also have an AMA Panel of #newPIs in #Parasitology who recently started their labs for Postdocs interested in transitioning to independence or going on the job market soon!!! #Postdocs_in_Parasitology come ask us anything at 3PM on Sep 15 in Clapp Auditorium @WoodsHole!

Manuel Fierro from the Beck Lab and Am @WDedkhad from the @MuralidharanLab closing out #MPM2023 with a bang!! 💪

@Wenjing_Cheng_ and @mehsehret presenting our new #malaria in situ #CryoET story at #MPM2023!!! ❄️🔬🦠