Cristiano Mota

Researchers @XTALUCIBIOFCTN1 uncover how metal-dependent formate dehydrogenase enzymes, key for CO2 reduction, are inactivated by oxygen. This discovery could pave the way for more robust bio-inspired catalysts. More: bit.ly/3YwVmP7 #CO2Reduction #ClimateChange

Very proud of this work by Vilela-Alves and coworkers, demonstrating at the atomic level how a W/SeCys-Fdh gets inactivated by O2. @RoySocChem @FCTNOVA @UCIBIO_Research @i4HBio @XTALUCIBIOFCTN1 @NMRFCTNOVA1 @itqbnova @esrfsynchrotron pubs.rsc.org/en/Content/Art…

The structure of the M405S variant of the Mo/W-dependent formate dehydrogenase DvFdhAB allowed the prominent role of Met405 in the geometry of the metal site to be probed. @NovaUnl @IUCr #CO2Reduction #MetalDependentFormateDehydrogenase #MoWEnzymes doi.org/10.1107/S20532…

Structure just published rcsb.org/structure/8PW0 in 2024-05-08 so not in the training dataset.

And another one, maybe without the training bias. Should bind specifically promoter region ATTTTAGTCGCGCCTAAAAT and it does again! Left is crystal structure, right is the AlphaFold3 model. Promoter is in red.

📢 ONLY ONE WEEK LEFT to submit your abstract to 2024 #Inorganic & Bioinorganic #Chemistry Conference, #2024IBiCC 📅: May 16 - 18, 2024 🌏: Lisboa 🇵🇹 2024ibicc.events.chemistry.pt

Check out our newest preprint reveiling a Mn sensor from #Deinococcus, bound to the promoter region of MntH. Mn ions accumulation is crucial for ROS scavenging & proteome protection in this highly resistant bacterium. @esrfsynchrotron @UCIBIO_Research doi.org/10.1101/2024.0…

📢 2024 #Inorganic & Bioinorganic #Chemistry Conference #2024IBiCC 📅: May 16 - 18, 2024 🌏: Lisboa, Portugal 🇵🇹 ⚠️ Key dates: abstracts submission: April 1, 2024 early bird registration: April 15, 2024 More info: 2024ibicc.events.chemistry.pt

Congratulations to @UCIBIO_Research researchers @XTALUCIBIOFCTN1 for the new study published @nchembio, in collaboration with @itqbnova @BIP6_Marseille revealing how a formate dehydrogenase can withstand oxygen exposure. More: bit.ly/3tVEhRO @i4HBio @FCTNOVA @NOVAunl

Our first preprint! Very proud of the excellent work by Vilela-Alves and coworkers, demonstrating at the atomic level how a W/SeCys-Fdh gets inactivated by oxygen. @FCTNOVA @UCIBIO_Research @i4HBio @XTALUCIBIOFCTN1 @NMRFCTNOVA1 @itqbnova @esrfsynchrotron doi.org/10.1101/2024.0….

Substrate-dependent oxidative inactivation of a W-dependent formate dehydrogenase involving selenocysteine displacement. biorxiv.org/cgi/content/sh… #bioRxiv

Check out our work unraveling the molecular basis for the unusual oxygen tolerance of W-Sec-FDH: a redox switch based on an allosteric disulfide bond regulates both high CO2 reductase activity and oxygen tolerance. nature.com/articles/s4158… #enzymatic #CO2reduction +

Congrats to Delfim Manuel Araújo Ferreira for his PhD in Molecular #Biosciences! 🎓 👏 His #research, "Unraveling the metabolic pathway of dissimilatory sulfate reduction", was supervised by @InsCardosoPere1 and co-supervised by Sofia Venceslau. #TeamNOVA #MolBioS @NOVAunl

Kicking off our fantastic @esrfsynchrotron @EMBLGrenoble @ESRF_Streamline workshop on ambient temperature crystallography with DoR Michael Krisch

So happy to see these results finally published in @nchembio! Very proud of the great work by @AnaOlivetree @cmota_15 and coworkers revealing how an FDH can withstand oxygen exposure.👏🍾@itqbnova @FCTNOVA @BIP6_Marseille @LS4FUTURE @i4HBio #CO2 rdcu.be/drzoQ

Congratulations to Cristiano Mota @XTALUCIBIOFCTN1 who coordinates one of the approved projects in the Call for Cooperation in Science between Portugal & Germany FCT-DAAD for 2023/2024, with a German team @unihh and T-REXX beamline at PETRAIII More bit.ly/3Hz99v4 #UCIBIO

Tracking W-Formate Dehydrogenase Structural Changes During Catalysis and Enzyme Reoxidation mdpi.com/2034544 #mdpiijms via @IJMS_MDPI

@Xuelei_Lai Congrats Xuelei!! I wish you the best!

New study developed by @XTALUCIBIOFCTN1 @NMRFCTNOVA1 @UCIBIO_Research @FCTNOVA unveiled the mechanisms of 3 inhibitors to an important human drug metabolizing enzyme by combining X-ray crystallography, NMR spectroscopy and kinetic assays. @ACSBioMed More: bit.ly/3mJtLap

Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case pubs.acs.org/doi/10.1021/ac…