cweidle

Not everyday you get tweeted by the pdb. 😊

@gonenlab Hard to say. Always seem to be ordering more. Always a new crystal form to optimize.

Please weigh in: how many beakers and how many glass bottles are sufficient per person in a biochemistry lab? I would say 50 bottles and 25 beakers each is a good starting point

I am happy to share that my first * first author paper is finally accepted and made it to PLOS pathogens :) pubmed.ncbi.nlm.nih.gov/34559844/

@gonenlab @GntlmnScientist Lol. Named our dewar frozone. In need of some repair.

@GntlmnScientist Frozone?

I propose to name our vitrification robot Cruella DeVille

I am happy to share our latest work on the differences in G protein activation by family A and family B GPCRs. I am very grateful that I was able to work on this with a great group of collaborators... science.sciencemag.org/content/369/65…

Our study, through wonderful collaboration with @LillyPad, reports and characterizes a small molecule positive allosteric modulator interacting with both the GLP-1 receptor and endogenous peptide hormone, working as a molecular glue. nature.com/articles/s4158…

@HutchBasicSci @MelodyGCampbell @fredhutch Congrats. Good to see a a cryoEM expert coming to the hutch!!!

We’re excited to welcome our newest faculty member @MelodyGCampbell on her first day @HutchBasicSci! She is helping build @FredHutch’s #cryoEM capabilities while continuing her work on integrins, proteins involved in autoimmune and inflammatory diseases. fredhutch.org/en/faculty-lab…

@gonenlab All three I suppose. Just as growimg nice crystals is the bottleneck of x-ray crystallography. Access to electron microscopes is the bottleneck for electron microscopy. In academia that seemed to translate to time waiting. In industry that seems to translate to cost.

@cweidle1 Yes. This keeps coming up. Access for screening or data collection or training?

Folks what is the number 1 rate limiting step for you to engage in learning and experiencing #cryoem? Please be frank because this can be useful in minimizing hurdles. There are no wrong answers.

We designed a SARS-CoV-2 spike glycoprotein covalently shut closed, and showed it is also applicable to SARS-CoV, to support structural, immunology and serology studies for COVID-19 and coronavirus research. Led by @Dr_MattMcCallum biorxiv.org/content/10.110…

Watch out SARS-CoV-2, we are coming for you! Our manuscript describing the isolation and structural characterization of the first human monoclonal antibody potently neutralizing SARS-CoV-2 has now been peer-reviewed and can be found here: nature.com/articles/s4158…

@andrewjborst Omg

Practice social distancing. This is what coronavirus looks like in an Italian hospital. vimeo.com/398334975

PDB release this week: 15 #COVID19 structures 7 fragment screening structures of main protease #structuralbiology

You can also use our online submission form here: fs3.formsite.com/DiamondLightSo…