Dan Kozome

Finally published! Thank you so much @PaolaLaurino and all lab members for your continuous support! @OISTeduでの博士研究がオンラインになりました！ #CAZyme #GH19 nature.com/articles/s4146…

biorxiv.org/content/10.6... most proteins are multi domain but our understanding of how architectures evolve is limited - we mapped 40K chitinases and show a stepwise grammar of domain gain/loss and localisation changes that predicts ecological strategy and physiological function

I successfully defended my thesis defense! Thank all for supporting my PhD Journey!

落合佳樹さん（OIST）にセミナーをして頂きます。 日時：2025年8月22日(金) 15:00-16:00 場所：山手3号館2階共通セミナー室 講演者：落合佳樹 (Yoshiki Ochiai) 所属：沖縄科学技術大学院大学(OIST) 題目：DNA/RNA標識ツールの開発を目指した非配列特異的DNA/RNAメチルトランスフェラーゼの探索と改変

Congratulations to Professor Paola Laurino and the Protein Engineering and Evolution Unit at OIST for winning the 2025 #FrontiersPlanetPrize National Championship for Japan, for their work on SAR11 - the ocean’s most abundant microbes!🏆 @PaolaLaurino oist.jp/news-center/ne…

全く新しい古細菌「スクナ古細菌」を発見しました！これまで知られている古細菌の中で最小のゲノム（238kbp）を持ち、その遺伝子機能は自己DNA複製に特化しています。驚くことに、海洋にはスクナ古細菌に近縁な未発見の古細菌の多様性が存在するようです。 biorxiv.org/content/10.110…

Functional and Structural Characterization of F1-ATPase with common ancestral core domains in stator ring biorxiv.org/content/10.110… #biorxiv_biophys

Metagenomic-scale analysis of the predicted protein structure universe biorxiv.org/content/10.110…

I'm truly excited to announce our new publication in @Nature unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to @AnujR2d2 for the fantastic illustration! LINK: nature.com/articles/s4158…

💫日本学術振興会インタビュー掲載🥰 特別研究員-DC1、海外特別研究員、特別研究員-PD、そして、JSTさきがけ研究員（兼任）としての研究生活についてお話ししています😀 これまで支えてくださった皆さまへの感謝を込めて、ご紹介させていただきます☘️ ⬇️インタビュー記事⬇️ jsps.go.jp/file/storage/j…

Happy to share our recent results led by Fukunaga san, a former lab member, now has his own group since Jan 2025 at Miyazaki. Novel and orthogonal riboswitches that can be used in the cell-free system were developed. educ.titech.ac.jp/bio/news/2025_…

腸内細菌由来の糖質加水分解酵素によるグリコシル化反応の論文が、Chem. Asian. J.誌に受理されました🎉 大沼研(近大農)との共同研究です🦠 Our latest paper, enzymatic glycosylation catalyzed by GH84 GlcNAcase, is out now in Chem. Asian. J.🎊 aces.onlinelibrary.wiley.com/doi/10.1002/as…

Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases Now out in Molecular Biology and Evolution Exciting collaboration with @kamerlinlab academic.oup.com/mbe/advance-ar…

🚨Preprint Alert!🚨 #ProteinDesign is advancing rapidly—wouldn't it be great to seamlessly combine design tools to achieve more than what each can do alone?🤔 Here, we introduce AI.zymes: A modular platform for evolutionary #EnzymeDesign.♻️🖥️ biorxiv.org/content/10.110… 1/🧵

国際インターンシッププログラムのお知らせ（日本の学部生・院生の方へ） #タンパク質工学 を用いた #バイオセンサー 開発に興味のある方, @IBCSinicaに立ち上がった新しいラボで1〜3ヶ月の #インターンシップ に参加しませんか？詳細と申し込みはこちら：iipp.tw/program

A new paper from @HoebartnerLab and @Uni_WUE reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity nature.com/articles/s4158…

We release our protein chatGPT, Evola! 🌟 chat-protein.com Evola comes in two versions: 10B & 80B. The 80B model has a 1.3B Saprot encoder & a 70B LLaMA3 decoder. Trained on 546 protein question-text pairs with an 150 billion word tokens! 💡🔬 biorxiv.org/content/10.110…

Please circulate! @czi and @ss_f_official have started the Global Science Scholars program to exchange postdocs between the US and Japan. @yachielab in Osaka University is one of the host labs in Japan side. czbiohub.org/program-ssfcz-…

The emergence of order from disorder, the dependence on initial conditions (evolutionary contingency), the fractal geometry of phylogenetic trees, epistasis, etc., are all attributes that protein evolution shares in common with other "complex" systems. arxiv.org/abs/2412.06115

New paper from the lab: rdcu.be/d2g28. You may remember the strange fractal assemblies we discovered in citrate synthase. Well, the reason we even found that protein is that we were interested in how conserved self-assembly is in an enzyme with a very basic function.

Excited to share my first paper as a postdoc with @KaHochberg @mpi_marburg! We've made some fascinating discoveries about the evolution of animal stem cells in colab with @jauchr and @deMendoza_Alex. 🧬🔬 Link: nature.com/articles/s4146… (1/n)