Yusuke Nasu

Where a signaling protein lives matters as much as what it does. Our new tool lets you interrogate this one compartment at a time. We built TerminaTOR, a genetically encodable inhibitor that silences mTORC1 at subcellular locations.

Hope to see many local friends at Q Microbio at Academia Sinica tomorrow! sites.google.com/view/q-microbi…

🔬Publication - by Dr. Steven Lin @NatureComms The newly established #genome-wide #CRISPR screening platform identified key regulators of #NK #cell functions, suggesting potential engineering targets for more potent NK #cancer #immunotherapy. doi.org/10.1038/s41467… #biochem

@QMP_IOP_AS An inspiring lecture on the history of Kamiokande, Kamland, and super-Kamiokande. We look forward to the launch of hyper-Kamiokande!

Excited to share that our AzoTag paper is now out in @NatureChemistry! 🥳 We demonstrate de novo chemo-optogenetics through the rational design of photoresponsive small molecules and selection of their artificial protein binding pairs. nature.com/articles/s4155…

[Please RT] Hiring: Research Technician II – Inoue Lab, WashU We build new optical sensors AND apply them in vivo to study brain disorders. Looking for someone excited about: stereotaxic surgery & mouse handling, neural circuit imaging Great prep for PhD / MD-PhD applicants.

Online now: Astrocytic glucose metabolism regulates the survival of newborn hippocampal neurons in the adult brain dlvr.it/TRv9GD

Took a break from science-posting for several months (will explain later), but excited to finally discuss some recent work from the lab. First up, a new solution to the old problem: How to engineer proteins to bind to a natural metabolite of interest, in this case biliverdin

Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing. biorxiv.org/cgi/content/sh…

Congratulations to Dr. Makoto Shirakawa @MakotoShirakaw2 on receiving the JSPP Young Investigator Award! The award ceremony was held on March 14 in Tokyo.

Excited to share our new paper on GRAB_PGE2-1.0, the first genetically encoded fluorescent sensor for monitoring spatiotemporal prostaglandin E2 (PGE2) dynamics in vivo! It enables real-time imaging in cultured cells, acute brain slices, and living mice.

私の所属する研究所が４０周年を迎えるにあたり、関連分野のリーダーを招いてシンポジウムを開催します。定量生物・生物物理関連では James Ferrell, Michale Elowitz, Wendell Lim らが登壇してくれます。三日間の濃密なプログラムです。ぜひお越しください。

Excited to share our new preprint with @fbayashi_T! We developed a boosted PURE-based cell-free FADS platform for rapid protein evolution. Using this platform, we evolved highly robust SP6 RNA polymerases and engineered split variants that sense diverse biomolecular interactions.

Our collaborative study with Yasui lab @sciencetokyo_ja is out in @ScienceAdvances ! With gRNA/GeNL tagging, we showed that cancer-derived small EVs can reach and be concentrated in urine via transcytosis, providing rationale for urinary liquid biopsy. science.org/doi/10.1126/sc…

羊土社『実験医学』3月号にて、Academia Sinicaおよび私の研究室の紹介記事を寄稿しました。研究環境や日々の取り組み、Academia Sinicaで研究を行う魅力についてまとめています。ご関心のある方にお読みいただけましたら幸いです。 Academia Sinicaでは各Institute（大学の学部に相当）でほぼ毎年PIの公募が行われていますが、それに限らず、大学院生やポスドクとして挑戦できる機会も数多くあります。近年は、欧米でポスドクをされている日本人研究者や、日本で研究を進めてこられた方々の着任も増えており、日本との距離も年々縮まっていると感じています。 本稿が、学生・ポスドク・PI志望の方を含め、海外での研究という選択肢を考えるきっかけになれば嬉しく思います。

📢 Applications are open! Join us @HHMIJanelia to explore next-gen fluorescent proteins, biosensors, imaging advances + ML/computational approaches to accelerate design. 🛏️ Meals & lodging covered Apply by May 21 ➡️ janelia.news/FPS26 @HHMIscience @ERSchreiter @agtebo

Come join us at the Quantitative Microbiology Symposium this May in Taipei! We’ve invited outstanding researchers working at the interface of the mathematical sciences and microbiology. For details and registration, see: sites.google.com/view/q-microbi…

🧪🧬 New preprint! What if the same biosensor could reveal how cysteine is regulated across life domains? We introduce Cystector, a genetically encoded fluorescent biosensor for real-time cysteine monitoring in living cells. biorxiv.org/content/10.648… 🧵A thread ⬇️

A new kalium channelrhodopsin from our collaboration with Wan-Chen Lin's lab! @IBMS_AcadSinica Strong suppression of axonal excitation and glutamate release from the long-range CA3 input for the critical tests at our hands :-) biorxiv.org/content/10.648…

【拡散希望】
４月から東北大学際研の助教として新規チームを立ち上げるにあたり, 学振研究員の受け入れを始めます. アクチンで人工細胞を走らせたい方, 未培養生物の細胞骨格の無細胞合成に興味のある方、ご相談ください. そんなのつまんねーから○○で申請したい, という強気な提案も歓迎です.