Daniel Bigham

I know Silicon Valley startups don't want to hear this..... But the combination of someone in the trades with deep domain expertise and Claude Code will run circles around your generic software. I talked to Cory LaChance this morning, a mechanical engineer in industrial piping construction in Houston. He normally works with chemical plants and refineries, but now he also works with the terminal He reached out in a DM a few days ago and I was so fired up by his story, I asked him if we could record the conversation and share it. He built a full application that industrial contractors are using every day. It reads piping isometric drawings and automatically extracts every weld count, every material spec, every commodity code. Work that took 10 minutes per drawing now takes 60 seconds. It can do 100 drawings in five minutes, saving days of time. His co-workers are all mind blown, and when he talks to them, it's like they are speaking different languages. His fabrication shop uses it daily, and he built the entire thing in 8 weeks. During those 8 weeks he also had to learn everything about Claude Code, the terminal, VS Code, everything. My favorite quote from him was when he said, "I literally did this with zero outside help other than the AI. My favorite tools are screenshots, step by step instructions and asking Claude to explain things like I'm five." Every trades worker with deep expertise and a willingness to sit down with Claude Code for a few weekends is now a potential software founder. I can't wait to meet more people like Cory.

This indie dev spent 1,400+ days building his game, Tangy TD, completely from scratch in C++. Seeing him and his wife react after the game earned $250,000 in its first week after launch is honestly beautiful.

Tony Robbins reveals what the most successful people in the world all have in common “People ask me all the time when I travel around the world. I've worked with some of the most successful athletes, multibillionaires, and entrepreneurs, and they ask what all these people have in common” “It's the person whose hunger does not go away. The hunger to be more, do more, give more, share more. It's not hunger just to reach a goal, it's an insatiable hunger, but they also have the relentlessness to push through all the obstacles that come up”

🤯BREAKING: Alibaba just proved that AI Coding isn't taking your job, it's just writing the legacy code that will keep you employed fixing it for the next decade. 🤣 Passing a coding test once is easy. Maintaining that code for 8 months without it exploding? Apparently, it’s nearly impossible for AI. Alibaba tested 18 AI agents on 100 real codebases over 233-day cycles. They didn't just look for "quick fixes"—they looked for long-term survival. The results were a bloodbath: 75% of models broke previously working code during maintenance. Only Claude Opus 4.5/4.6 maintained a >50% zero-regression rate. Every other model accumulated technical debt that compounded until the codebase collapsed. We’ve been using "snapshot" benchmarks like HumanEval that only ask "Does it work right now?" The new SWE-CI benchmark asks: "Does it still work after 8 months of evolution?" Most AI agents are "Quick-Fix Artists." They write brittle code that passes tests today but becomes a maintenance nightmare tomorrow. They aren't building software; they're building a house of cards. The narrative just got honest: Most models can write code. Almost none can maintain it.

Every time you get a cancer biopsy, the lab makes a tissue slide that costs about $5. It shows the shape of your cells under a microscope, and every cancer patient already has one on file. There’s a much fancier version of that test called multiplex immunofluorescence (basically a protein-level map showing which immune cells are near your tumor and what they’re doing). It costs thousands of dollars per sample, takes specialized equipment most hospitals don’t have, and barely scales. But it’s the kind of data oncologists need to figure out whether immunotherapy will actually work for you. Right now, only about 20 to 40% of cancer patients respond to immunotherapy, and one of the biggest reasons is that doctors can’t easily tell whether a tumor is “hot” (immune cells actively fighting it) or “cold” (immune system ignoring it). Microsoft, Providence Health, and the University of Washington trained an AI to analyze the $5 slide and predict what the expensive test would show across 21 different protein markers. They called it GigaTIME, trained it on 40 million cells in which both the cheap slide and the expensive test coexisted, and then turned it loose on 14,256 real cancer patients across 51 hospitals in 7 US states. The results landed in Cell, one of the most selective journals in biology. The model generated about 300,000 virtual protein maps covering 24 cancer types and 306 subtypes. It found 1,234 real, verified connections between immune cell behavior, genetic mutations, tumor staging, and patient survival that were previously invisible at this scale. When they tested it against a completely separate database of 10,200 cancer patients, the results matched up almost perfectly (0.88 out of 1.0 agreement). Nature Methods named spatial proteomics (mapping where specific proteins sit inside your tissue) its Method of the Year in 2024, and specifically cited GigaTIME in a March 2026 update as a model that “democratizes” this kind of analysis. The full model is open-source on Hugging Face. Any cancer research lab with archived biopsy slides, and most of them have thousands, can now run virtual immune profiling without buying a single piece of new equipment.

Elon Musk: I recommend that Israel do conspicuous acts of kindness to the people in Gaza. “There were really three things that were my strong recommendations visiting Israel. One is obviously that one has to get rid of Hamas fighters where reform is impossible. Their only goal is to kill Israelis. They ought to be either killed or imprisoned because otherwise they will simply kill more Israelis. Then, the second thing is you've got to change the indoctrination in the schools so that kids are not taught to hate from the moment they are 2 years old. And then the third thing is, which is a very hard thing to do in this situation, is conspicuous acts of kindness to the people in Gaza. It's just that much harder to hate someone if you do nice things for them. Even if they try to bite your hand when you do it, keep doing it.” European Jewish Association, January 2024

Working at OpenAI is fun because questioning everything and taking risks is part of the culture. Within Codex, the team asks itself how we could make it an order of magnitude better every few months and then sets most things aside to go and do it across the entire stack. Some examples were the Codex App and our first deployment of Cerebras inference with WebSockets. We are now well under way on the next bet and it’s making even our best engineers nervous as it’s at the edge of what’s possible today.

Since we *already* can do n=1 custom cancer vaccines for *pets* at a price that's economic for at least some people, the "we can't scale it" issue doesn't seem entirely true either?