Daniel Zabransky

Older adults respond well to anti-PD1 despite age-related immune differences, @danielzabransky Findings may not extend to therapeutic cancer vaccines, which likely require naive T cells Summary of findings below⏬ 🔗 nature.com/articles/s4146…

5/ We hope this study will help identify aging-related signals and pathways that can be further evaluated and targeted for personalized immunotherapy approaches for patients.

4/ These differences in older patients included diminished cytokine responses, reduced pools of naïve T cells with increased relative expression of immune checkpoint molecules, and more robust effector T cell expansion in responders compared to non-responders.

1/ Excited to share our study (rdcu.be/eiAyr) published today in @NatureComms led by @ChesterKao1, @SorenCharmsaz, and Hua-Ling Tsai evaluating age-related differences in immune responses in patients with cancer treated with immune checkpoint inhibitors (ICIs).

🔬Ready to delve deep into the #TumorMicroenvironment @AACR? Join @LabMcgaha and me as we co-chair the symposium “The Microenvironment: Beyond Surrounding the Tumor.” Featuring talks by @ChetritNir @danielzabransky @neilqtay @GauriMirji Jun Li, Ruiyuan Xu, & Xiaoyu Yuan #AACR24

If you enjoyed the talk by @danielzabransky at #AACR24 during the Microenvironment session, be sure to read his recent paper on aged fibroblasts in #pancreaticcancer. bit.ly/3VOimHX @AACR

In a recent article, BDP @AshaniTW and @danielzabransky discuss their new study from @hopkinskimmel which addresses age-related changes in fibroblasts and their connection to pancreatic cancer progression. genengnews.com/topics/cancer/…

@HopkinsMedicine @sibleyonline @IntegrityCE @AshRajputInDC @hopkinskimmel @MarkYarchoan @marinabaretti @KLafaro @freddyeescorcia @hopkinskimmel @HopkinsMedicine @IntegrityCE 👍Dr. Mark Yarchoan @MarkYarchoan also led our last session of the conference - focusing on #chlolangiocarcinoma with James Harding, Chris Schubert, Jackie Birkman-Gartman, and @danielzabransky

Ugh. I couldn’t be more proud. In the last year @FaneMitchell then @danielzabransky and now @Yash_Chhabra. And before them Marie Webster, not to mention all the others who did not take PI roads. Best part of mentoring is watching my ducklings fly 💕💕 Fly high Yash, you got this!

@Aiims1742 @CR_AACR @DrLizJaffee @AshaniTW @hopkinskimmel Thanks for reading! We are so excited to continue studying how aging impacts pancreatic cancer progression. Have to express my immense gratitude to @AshaniTW and @DrLizJaffee who have given me so much support during my fellowship and now as I've started my own lab.

Great to see this work out in @CR_AACR. Led by @danielzabransky and co-mentored by @DrLizJaffee and @AshaniTW @hopkinskimmel Fibroblasts in the aged pancreas drive #PancreaticCancer progression aacrjournals.org/cancerres/arti… Neat example of convergence science.

Loved working with @HongYuenWong @JGordetsky TigerSheng @K_Schaffer @VUMCurology @GA_Giannico @JeffRathmell @benhopark on a single-cell #RNAseq study to better define cribriform #prostatecancer and its TME in @NatureComms. @VUMC_Cancer rdcu.be/cXtfT

@AshaniTW @HEP_Journal Thank you @AshaniTW you are far too kind! I’m lucky to have so many amazing people to work with and learn from.

One of the cool things about coming to Hopkins has been to mentor talented physician scientists. @danielzabransky is one of them, and he's just published this really nice paper in @HEP_Journal ! #ProudPI aasldpubs.onlinelibrary.wiley.com/doi/full/10.10…

Super proud of our team on our latest- here we directly compare the TME of 4 HCC mouse models with varying anti-PD1 sensitivities- tagging twitter users @danielzabransky @jleathe3 @SorenCharmsaz @NicoleElizGross @ltkagohara @DrLizJaffee @MarkYarchoan aasldpubs.onlinelibrary.wiley.com/doi/abs/10.100…

Great work from our team lead by @wonjinho1 & @danielzabransky profiling TME of murine #HCC models pub in #Hepatology ➡️Hepa 1-6: invalid ICI model, HLA mismatch w/ C57BL6 ➡️Hep53.4 & RIL175 - mod ICI responsive ➡️TIBx: ICI-resistant aasldpubs.onlinelibrary.wiley.com/doi/abs/10.100…

Excited to share our manuscript w/ genomic & transcriptomic data from >450 #Cholangiocarcinoma pts in JCO PO: ascopubs.org/doi/abs/10.120… ➡️Actionable alterations in >30% ➡️4 molecular clusters w/ unique immunophenotypes ➡️IDH1⏫M2 mac; FGFR2⏬immune infiltrat

@AshaniTW @MarkYarchoan @HeumannThatcher Thank you Ashi you are so kind!

@danielzabransky @MarkYarchoan @HeumannThatcher So proud of you Dan!! You are the best!

Anyone is lucky to mentor a #ASCO YIA recipient. But tonight I get the chance to celebrate TWO mentees for their 2022 YIAs: @HeumannThatcher (MEKi in BTC), and @danielzabransky (IDH1+ & BTC fibroblasts). Congratulations to these rising stars!