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HydraDAO
475 posts
HydraDAO
@daohydra
Funding and incubating replacement research to extend human lifespan. https://t.co/PKzpK99eds • $HYDRA 🫀
Switzerland Katılım Ağustos 2021
147 Takip Edilen2.6K Takipçiler
HydraDAO retweetledi
Getting old shouldn't be viewed as inevitable, just because it happens to everyone. It's a disease that kills over 100,000 people a day, and hopefully it will be optional in the future.
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HydraDAO retweetledi
bodyoids may be the key to extending human lifespan
beyond perfectly-matched replacement organs and tissues whenever you need them, imagine replacing everything all at once, instead of piece by piece
a head or brain transplant onto a brand new body, a clone of yourself, when your current body can no longer be repaired
scientists have both successfully cloned primates and performed head transplants on primates
in fact, the reason the primate died 9 days after the head transplant, in the 1970s, was due to the body rejecting the head - something a clone bodyoid would solve
arpa-h recently launched a program called front with hundreds of millions of dollars working on progressive replacement of the brain, the one piece we of course cannot swap out entirely
at hydradao we now have rats, rabbits, and even pigs walking days after complete transection of the spinal cord, ensuring a head transplant would not lead to quadriplegia
pieces of the puzzle are coming together to form a path towards radical life extension that doesn't require us to solve the mysteries of aging
bodyoids are at the center of it all
Kai Micah Mills@kaimicahmills
the ultimate solution is through technology we engineer what has been called a bodyoid: brainless animal bodies that provide as much meat as we desire without harming any sentient beings this would transform medicine - the same platform would allow us to grow organs on demand, eliminate transplant waiting lists, and produce perfectly matched tissues for each patient experimental therapies could be tested on full biological systems without involving conscious animals, regenerative medicine would accelerate as entire replacement tissues become manufacturable in the same way that agriculture turned food from a scarce resource into an abundant one, engineered bodyoids would turn biological material into infrastructure - meat without slaughter, organs without donors, and medical research without sentient suffering
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HydraDAO retweetledi
the bodyoid faq:
- how would bodyoids exist without a brain?
biology already gives examples - in rare conditions like hydranencephaly, large portions of the brain, including the cerebral hemispheres, fail to develop
the body still forms, organs grow, and many basic physiological systems function, but the neural architecture required for consciousness never emerges
a bodyoid would apply the same principle intentionally: allow normal body development while preventing formation of the structures associated with sentience - development continues, tissues mature, organs grow, but the organism never forms a conscious brain
- why not just do cultured meat?
cultured meat may work for simple tissues, but biology already knows how to build vascularized muscle, fat marbling, connective tissue, skin, and bone - a bodyoid lets development do the work
we then also unlock organs on demand, blood, skin, collagen, and countless other biological materials
also, people clearly don't find it good enough
- why doesn't everyone just stop eating meat?
good luck
- are you jewish?
no
- is this science fiction?
no - we are actively funding labs with millions of $$ working on brainless clones and other steps of this process via @daohydra, some of whom have already had successes in small mammals (mouse bodyoids that lack consciousness, have no head/arms/legs, only a tail, which they are still working to remove)
- why not just print organs?
bioprinting is promising but extremely difficult at full scale - organs are dense vascular systems with billions of cells arranged precisely, a bodyoid grows them naturally
- are human bodyoids next?
hopefully! the bottleneck in modern medicine is biological material
right now, people die waiting for organs - kidneys, hearts, livers, lungs, skin grafts, bone, blood products - demand vastly exceeds supply
a human bodyoid platform would mean organs on demand - clones would mean perfectly matched tissues grown for each patient - no waiting lists, no rejection, no need to rely on deceased donors
it would also transform trauma care and surgery where severe burns could receive unlimited skin grafts, damaged organs could be replaced rather than managed, experimental therapies could be tested on full biological systems without involving conscious humans, and the list goes on
so, yes, you should want your own personal bodyoid
- this is evil/an abomination/going against god/etc/you should be burned at the stake
you should see what we do to the real pigs - ethically speaking, this is essentially a meaty plant
bodyoids are coming :)
btw, I have enjoyed many hours reading hundreds of very funny comments, thank you
Kai Micah Mills@kaimicahmills
the ultimate solution is through technology we engineer what has been called a bodyoid: brainless animal bodies that provide as much meat as we desire without harming any sentient beings this would transform medicine - the same platform would allow us to grow organs on demand, eliminate transplant waiting lists, and produce perfectly matched tissues for each patient experimental therapies could be tested on full biological systems without involving conscious animals, regenerative medicine would accelerate as entire replacement tissues become manufacturable in the same way that agriculture turned food from a scarce resource into an abundant one, engineered bodyoids would turn biological material into infrastructure - meat without slaughter, organs without donors, and medical research without sentient suffering
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HydraDAO retweetledi
growing meat from cells will work for some simple cases, but it is also trying to recreate what biology already does effortlessly
a bodyoid lets development do the work - vascularized tissue, fat marbling, connective tissue, bone-in cuts, all the complexity that makes real meat what it is, using the bodyoid itself as the factory
and then of course once we have unlocked that it is not just meat - it is organs on demand, blood, skin, collagen, and every other biological material medicine currently rations through scarcity
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HydraDAO retweetledi
the ultimate solution is through technology
we engineer what has been called a bodyoid: brainless animal bodies that provide as much meat as we desire without harming any sentient beings
this would transform medicine - the same platform would allow us to grow organs on demand, eliminate transplant waiting lists, and produce perfectly matched tissues for each patient
experimental therapies could be tested on full biological systems without involving conscious animals, regenerative medicine would accelerate as entire replacement tissues become manufacturable
in the same way that agriculture turned food from a scarce resource into an abundant one, engineered bodyoids would turn biological material into infrastructure - meat without slaughter, organs without donors, and medical research without sentient suffering
Lewis Bollard@Lewis_Bollard
Hidden on page 744 of the farm bill the House Agriculture Committee passed Thursday is a provision that would condemn millions of pigs to a lifetime in gestation crates. Rebranded the 'Save Our Bacon Act,' it's a pork-industry play to wipe out every state law banning the sale of pork from crated pigs — laws the conservative Supreme Court upheld in 2023. Over 85% of Democrats and Republicans oppose these crates. Voters have backed ballot measures to ban them in state after state. The pork industry knows it can't win a straight vote on this. So it's burying the provision in an 800-page bill and hoping no one notices. Contact your senators and representative today and tell them: oppose the farm bill unless the Save Our Bacon Act is stripped out. You can reach them at senate.gov and house.gov — it takes two minutes and it matters.
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@arthrosis_anon @kaimicahmills @cryopets @cryodao I'm curious what else you find to be a distraction in longevity
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@kaimicahmills @cryopets @cryodao cryo is a massive distraction when it comes to longevity. i want to actually be alive and not frozen.
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we're launching a new show called ice breakers where we talk to the leading scientists, entrepreneurs, and operators in the field of cryopreservation
stories of triumphs, failures, breakthroughs, risk, sacrifice, and resilience that have never before been told
coming soon 🥶
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HydraDAO retweetledi
Here is a scientist who devoted his life to answer the question whether his approach can extend lifespans. And a lot of the comments are death apologists saying that is wrong or impossible. Imagine someone working on potentially saving your parents' or your children's lives, and the pain and suffering of heart disease, stroke, mental and physical decline... And you take time out of your day to go yell into the X void that that's wrong/impossible.
My message to the naysayers - you do know you can always decide to not take the therapy once it is available, right? You can decide to just die from aging. Nobody will force you.
In the meantime, we continue funding frontier science at @daohydra and @cryodao. It's INEVITABLE.
Dr. Thomas Ichim@exosome
There are jellyfish that can live forever. Soon, there will be humans who an live forever That’s my job @ImmortaBio
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HydraDAO retweetledi
Excited to share our ethical case for longevity science.
We address concerns about overpopulation, inequality, and loss of meaning, and argue that life extension is ethically grounded in autonomy and the intrinsic value of life.
Anti-ageing research is a continuation of medicine’s commitments to preserve life, reduce suffering, and respect individual choice.
sciencedirect.com/science/articl…
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HydraDAO retweetledi
I tracked every billionaire who died in the last decade.
389 deaths. $2.17 trillion in wealth. 6 helicopter crashes.
Here's what I found.
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HydraDAO retweetledi
How could tiny breakthroughs in aging science change U.S. GDP and population growth?
What’s the economic value of making 41 the new 40, or 65 the new 60?
How many lives could we create or save if we could slow reproductive or brain aging by just 1 year? What would billions of healthier hours be worth to the economy, if we assume no change in the age of retirement?
I spent the last two years obsessing over the design, research, and execution of this project. The result is a book upcoming with Harvard University Press, a preprint, and—maybe your favorite part—an interactive simulation tool that lets you input your own timelines and assumptions for specific breakthroughs in aging bio, then see the ROI in terms of US population & GDP growth.
From @RickEcon and Jason DeBacker—the economists who co-developed the open-source, macro model that made this project possible—to extensive comments by @tylercowen, @sapinker, Richard Freeman, @NDHendrix, @ebudish, @elidourado, @geochurch, @jasoncrawford as well as interviews with 102 scientists (!) and countless iterations with award-winning designer Giorgia Lupi and the @pentagram team, we built something we hope will be a benchmark for how scientists, economists, designers, philosophers, entrepreneurs and storytellers can come together to paint, fund, and build different flourishing futures for our species.
I couldn’t be more excited to share this. It’s the start of an open and evolving project—the labor and product of love, obsession, and unrelenting care.
I hope you have fun playing with our simulation tool — and if you do, please share!
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HydraDAO retweetledi
18 protocols prepared, 200+ rat surgeries performed, and possibly the largest transected spinal cord dataset to date.
Solving spinal cord fusion would be a major step toward replacement.
@daohydra $HYDRA
HydraDAO@daohydra
In 2025, Dowell Bio took a major step toward bringing spinal cord fusion into clinical practice. Goal: develop a reproducible fusogen composition that can translate from transection models to human spinal cord injury. Q3 - Built the roadmap from current literature to clinical trials - Sourced key components globally - Prepared 18 protocols testing compound combinations, plus several novel synthesized candidates Q4 - Performed 200+ rat surgeries - Delivered full post-op care and rehab - Recorded dozens of videos per animal for functional tracking Now - Processing results - Captured thousands of spinal cord microscopy images and paired them with clinical profiles to form the largest transected spinal cord dataset to date - Preparing a patent and 3 papers First rats, then pigs. More coming soon. ❤️🔥
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HydraDAO retweetledi
This is incredibly important work. Solving spinal cord fusion would be the key replacement breakthrough.
HydraDAO@daohydra
In 2025, Dowell Bio took a major step toward bringing spinal cord fusion into clinical practice. Goal: develop a reproducible fusogen composition that can translate from transection models to human spinal cord injury. Q3 - Built the roadmap from current literature to clinical trials - Sourced key components globally - Prepared 18 protocols testing compound combinations, plus several novel synthesized candidates Q4 - Performed 200+ rat surgeries - Delivered full post-op care and rehab - Recorded dozens of videos per animal for functional tracking Now - Processing results - Captured thousands of spinal cord microscopy images and paired them with clinical profiles to form the largest transected spinal cord dataset to date - Preparing a patent and 3 papers First rats, then pigs. More coming soon. ❤️🔥
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HydraDAO retweetledi
Proud to organise this research. Spinal cord fusion, peripheral nerve fusion, head transplants - soon on the shelves
HydraDAO@daohydra
In 2025, Dowell Bio took a major step toward bringing spinal cord fusion into clinical practice. Goal: develop a reproducible fusogen composition that can translate from transection models to human spinal cord injury. Q3 - Built the roadmap from current literature to clinical trials - Sourced key components globally - Prepared 18 protocols testing compound combinations, plus several novel synthesized candidates Q4 - Performed 200+ rat surgeries - Delivered full post-op care and rehab - Recorded dozens of videos per animal for functional tracking Now - Processing results - Captured thousands of spinal cord microscopy images and paired them with clinical profiles to form the largest transected spinal cord dataset to date - Preparing a patent and 3 papers First rats, then pigs. More coming soon. ❤️🔥
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HydraDAO retweetledi
hundreds of rat spinal surgeries later, we have a patent, 3 papers, and the largest transected spinal cord dataset in the world coming out of dowell bio, incubated by hydra
up next: 🐖
we are paving the way for both spinal cord fusion and whole-body replacement
HydraDAO@daohydra
In 2025, Dowell Bio took a major step toward bringing spinal cord fusion into clinical practice. Goal: develop a reproducible fusogen composition that can translate from transection models to human spinal cord injury. Q3 - Built the roadmap from current literature to clinical trials - Sourced key components globally - Prepared 18 protocols testing compound combinations, plus several novel synthesized candidates Q4 - Performed 200+ rat surgeries - Delivered full post-op care and rehab - Recorded dozens of videos per animal for functional tracking Now - Processing results - Captured thousands of spinal cord microscopy images and paired them with clinical profiles to form the largest transected spinal cord dataset to date - Preparing a patent and 3 papers First rats, then pigs. More coming soon. ❤️🔥
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In 2025, Dowell Bio took a major step toward bringing spinal cord fusion into clinical practice.
Goal: develop a reproducible fusogen composition that can translate from transection models to human spinal cord injury.
Q3
- Built the roadmap from current literature to clinical trials
- Sourced key components globally
- Prepared 18 protocols testing compound combinations, plus several novel synthesized candidates
Q4
- Performed 200+ rat surgeries
- Delivered full post-op care and rehab
- Recorded dozens of videos per animal for functional tracking
Now
- Processing results
- Captured thousands of spinal cord microscopy images and paired them with clinical profiles to form the largest transected spinal cord dataset to date
- Preparing a patent and 3 papers
First rats, then pigs. More coming soon. ❤️🔥
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HydraDAO in 2025 ❤️🔥
- Raised $4.1M+ to fund and incubate replacement research
- Initiated the ABF (American Biostasis Foundation) @abfndn alongside @cryodao to have our own DAO-run lab for biostasis research and storage.
- Launched our first spinal cord transection restoration program (Dowell spinal fusogens)
- Showed the world that a severed spine can be repaired with only 5 days of recovery.
- Discovered swine can walk after 40 days of having their spines severed and reattached.
- Introduced our first incubated company: NewBrain (hippocampus replacement)
- Upgraded lab capability with a new rotary microtome
- Sponsored the Autonomous Microsurgery Workshop
This is only the first year. Spinal reconnections in year one, who knows what year two will bring?
In 2026, we will be hailing $HYDRA. 🫀
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HydraDAO retweetledi
CryoDAO in 2025 🥶
- Initiated the American Biostasis Foundation @abfndn to construct the most advanced biostasis research and storage facility in the world
- Milestones 1-3 completed for @thecryorat and microCT acquired
- Incubated @daohydra for replacement research
- Spoke about cryopreservation and DeSci at dozens of conferences
- Funded study of physician estimates of the feasibility of human biostasis and future revival
- Expanded CPA database project
- Launched the CryoDAO treasury dashboard (treasury.cryodao.org)
- Announced the upcoming @inevitablesci
We have more exciting research projects in the pipeline - we will announce these throughout the coming year alongside progress updates for our active projects.
2026 will be a magic year for $CRYO. 🧊
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HydraDAO retweetledi
it is mind-numbingly obvious that cryo and replacement are the only viable paths to indefinitely extending max human lifespan within our lifetimes
before long the rest of the field will catch on, billions of dollars will flow into both, and our orgs will be positioned to lead
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