David King

Please have a read of our newest paper "Increased Replication Stress Determines ATR Inhibitor Sensitivity in Neuroblastoma Cells": mdpi.com/2072-6694/13/2…. Thread explaining it below 1/n

@CCLG_UK @Bham_Childrens Congrats 🎉

🌟 A huge round of applause to the Birmingham Late Effects Team for winning #TeamOfTheYear at the #CCLGMemberAwards! 🏆 They deliver exceptional care, ensuring every patient receives individual, accessible and adaptable care. Their dedication is truly commendable! #CCLG2024

@kls_kat @DennisRenMD @DFTBubbles @Damian_Roland And as an anecdote saw a neonate once crying/unsettled. Admitted for obs. Did bloods - all normal but sent a blood culture. Didn't start abx. Seen on morning w/r, had been well and was going to be d/c'd until lab phoned through blood culture ? Strep (was GBS bacteraemia).

@kls_kat @DennisRenMD @DFTBubbles @Damian_Roland I've seen a lot of people 'hold' them until starting abx. Depends on whether you think BC stand alone as a useful investigation without necessarily treating. I think they do.

Paeds friends! Straw Poll! 🩸Paediatric blood cultures (BC) 💉 (Excluding sick kids) For kids that have bloods ?bacterial infection, what’s your practice when you take bloods looking at inflammatory markers? Bonus tips for EBM!! @DennisRenMD @DFTBubbles @Damian_Roland

📢 PhD position! Interested in studying mechanisms of cancer dormancy and chemotherapy-resistance? We are looking for an enthusiastic and motivated researcher to join our team as a PhD student! Learn more about the position in the link below 👇 findaphd.com/phds/project/t…

@AuntyEmesis Looks better from further away 👍

Why do the videos make it look so easy? When will I learn that I’m not a cake decorator?? #7 #WontGiveUpMyDayJob #amatuerBaker 🎂🏀⛹️

💥 NHS STAFF 💥 Please consider signing this open letter to @VictoriaAtkins & @AmandaPritchard at @NHSEngland expressing your dismay at their extraordinary decision to cut @NHSPracHealth funding for hospital staff. Please share widely 🙏 Letter here: forms.gle/YmXpi8dxSbW7UR…

@mstotty88 @ldwijesinghe @NHSE_WTE Totally. But if one SHO is on a NWD and one is post nights who else is there to do the routine stuff. It's an imperfect system. I've been through it.

@davidking83 @ldwijesinghe @NHSE_WTE Registrars are learning to be consultants. Their job plan should mirror yours.

@mstotty88 @ldwijesinghe @NHSE_WTE I agree completely. Except for the procedure lists.

@davidking83 @ldwijesinghe @NHSE_WTE It’s also not the role of the registrar…

@mstotty88 @ldwijesinghe @NHSE_WTE Yes, it's consultant led and delivered. But it's probably not the role of the consultant to be doing ward admin, routine procedure lists, clerking chemo admissions etc. Generally consultant expansion would be justified by increased activity not covering other roles.

@davidking83 @ldwijesinghe @NHSE_WTE I know little about paediatric oncology. But I imagine it’s very consultant led and delivered. If you need more people to staff rotas why don’t you need more to staff consultant rotas? It is not 24/7 consultant led and delivered?

@mstotty88 @ldwijesinghe @NHSE_WTE Do you think that sort of consultant expansion is required in your specialty? Eg. radiology might accommodate but my own probably doesn't. But we need more people to staff the rotas.

@mstotty88 @ldwijesinghe @NHSE_WTE I suppose it's 20% people who are post CCT. The concern would be ending up like neurosurgery with lots of people unable to get consultant jobs and having to do lots of fellowships etc.

@mstotty88 @ldwijesinghe @NHSE_WTE This is conflating the view that trainees = service providers. Do we need 20% more consultants? I'd argue not.

@ldwijesinghe Looks like @NHSE_WTE need to plan a 20% increase in training numbers across the board starting now. Will take a while to get to fruition.

@DrDonSharkey @RCPCHtweets Problem is trainees always provided vast majority of service esp. at middle grade level. LTFT breaks this link. But we don't necessarily need more CCT holders. So who covers the service? Fellows, SAS doctors etc are hard to find.

@dr_woodall @DrRJWebb Ah yes, clogs. Only to be found in 19th century Holland and operating theatres. A quaint tradition.

@jess_wan1 Brilliant, well done Jess.

Outcome 6: Completion of Training in Paediatrics, achieved. Can't stop crying happy tears!

@jonathan_davis3 @drbretty So in certain units in the UK, CRP>40 = LP. NICE say > 10 or used to, which I followed for a while. It's a low yield investigation for sure.

@drbretty Nna

#neotwitter: Which of these C-reactive protein (CRP) levels would make you do an LP to exclude meningitis in a neonate with suspected sepsis? (Pick the LOWEST CRP that would make you do an LP)

Our newly funded project looking at the role of copy number alterations in embryonic development/paediatric tumour initiation (a collaboration with @bryantlab1) has just kicked off-we are grateful to @CCLG_UK/@LPTrustUK for their continuous support: littleprincesses.org.uk/news/three-cut…

@DrNickTwit @apsmunro @timricketts_ @Louisdebernard Lansoprazole is a disappointing choice here.

@apsmunro @timricketts_ @Louisdebernard Excellent news! Do I need something with better CSF penetration then, just in case 😂?

You’re marooned on a tropical island. There’s plentiful running water and food. You have to survive for as long as possible. You’re allowed 5 medications to bring with you. What do you bring?

@doctorhelgi @Oesophagusuk Also career average pension will make it worth more.

@Oesophagusuk I agree, but over time they benefit from earlier pay progression than we did so arguably do better than if it was just a straight pay rise. Particularly if the DDRB settlement next year is decent.

I'm so pleased we have a deal and I hope it gets voted through. It feels fair to me. All we need now is a deal for junior doctors and we can all get on with our lives. #doctorstrikes i.emlfiles4.com/cmpdoc/2/5/8/0…

@jakepmann This is all very true. The only other thing I'd add, is that it needs to be fundable, however that is defined. You can't do research without money.

How I picked my research field Four questions to help decide what to work on There are three key decisions in life: what you do, who you spend your time with, and where you live. All three are interrelated. 1. What is the expertise of where you are? 2. What is the most pressing need in your clinical field? 3. What will give you a niche? 4. What do you think is exciting? This is the general process I followed to decide to work on biliary inflammation in children. From there is takes a huge amount of reading and preliminary work to define a specific research question e.g. “What is the role of macrophage subset x (defined by genes a, b, c) in activation of other cell y in biliary atresia?”. At the time of writing, I am still trying to figure out this specific question. See the full blog here: jakepmann.com/research-field/