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New article from me and @TAH_Sci 🔥
On what immunity debt actually means, and why it alone is sufficient to explain disturbances in seasonal communicable disease dynamics post pandemic
academic.oup.com/cid/advance-ar…
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Alasdair Munro
24.5K posts
Alasdair Munro
@apsmunro
@NIHRresearch Academic Clinical Lecturer | Paediatric Immunology and Infectious Diseases | Clinical trials | Vaccines | Antibiotics | @apsmunro.bsky.social
United Kingdom Katılım Nisan 2013
587 Takip Edilen52.5K Takipçiler
Alasdair Munro retweetledi
This is a brilliant article on Meningitis B by Alasdair Munro - a senior clinical research fellow in paediatric infectious disease. He runs clinical trials and study infections in children, including Covid-19. alasdairmunro.substack.com/p/menb-or-not-…
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My new post looks at the current meningococcal outbreak in south east England
What is meningococcus?
What's happening with the outbreak?
What's the deal with the vaccines?
open.substack.com/pub/alasdairmu…
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Alasdair Munro retweetledi
If the children’s module does the same as this one, and simply vindicates what we already knew and planned to deliver, I will require veterinarian levels of sedation to get through it
UK Covid-19 Inquiry@covidinquiryuk
1/ The Chair of the UK Covid Inquiry, Baroness Hallett has made a statement on her findings and recommendations.
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Alasdair Munro retweetledi
Another wonderful summary from @apsmunro on the current situation of the MenB outbreak in the UK.
Please make sure you read carefully and share if you believe it will be useful for someone.
#pedsID #menBoutbreak @ESPIDsociety @seipweb
open.substack.com/pub/alasdairmu…
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Alasdair Munro retweetledi
From today, the NHS will offer free chickenpox vaccinations as part of its routine childhood immunisation programme.
This will keep more children well and in school, protecting them from a disease that can be serious, and reduce the time parents take off work to care for them.
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@MaxDWolf @apsmunro @EbonyJHilton_MD viruses to make a point is either done in bad faith or in ignorance.
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Tell me you don’t practice medicine without telling me you don’t practice medicine.
Hepatitis B/C wasn’t a problem for some, until it caused liver cancer later.
HPV was “handled well by the young” until it’s linked to cervical/esophageal cancer.
EBV was no big deal until MS.
Rose Edmunds@RoseEdmunds
@BenK_Data @EbonyJHilton_MD Covid is no different from any other respiratory virus. Clearly encountering a novel virus late in life is dangerous. But younger adults and in particular kids were well equipped to deal with this eventuality. Why can’t people understand this?
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Alasdair Munro retweetledi
This issue of Calvin and Hobbes lives rent-free in my mind
Patrick Heizer@PatrickHeizer
Dads: a simple reframe that has helped me actually want to play with my kids more: There is going to be a last time that they ever ask me to play together, I won't know when that will be, and that I'll desperately wish for it again once it's past. Life is brief. Truly savor it.
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@FReichert667 @BradSpellberg @ABsteward @PaulSaxMD This happens from time to time and we usually just rationalise to single agent (ASP/Cefazolin), but if very keen on GN cover I would prob try to barter down to Cefazolin + Toby/Gent/Amik?
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#idxposts
If a pt with leukemia and septic shock, empirically started on piptaz, teico and tobramycin grows s.aureus in cultures: add cefazoline? Or is piptaz and teico enough for you?
Gram-negative coverage needs to be kept due to absolute granulopenie, mucositis and instability
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Alasdair Munro retweetledi
Why should someone have to be afebrile to receive oral antibiotics? Are iv antibiotics better fever reducers? What if I gave Tylenol with the oral antibiotics? This is traditional, non evidence-based “because we said so” nonsense, typical of shmidelines.
S.Enf.Infecciosas HRUM@infeccHRUmalaga
Guía @IDSA paso a #ViaOral💉➡️💊 en #ITUcomplicada realizarla SI 1️⃣Afebril, 2️⃣Estable y 3️⃣Foco controlado Algoritmo muy ilustrativo📸2 Tabla dosis y concentración orina de ATB orales📸3 Usa la #ViaOral💋 y reduce #flebitis y #bacteriemias por catéter! 🔗🆓academic.oup.com/cid/advance-ar…
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Alasdair Munro retweetledi
@Parody_RCGP If I remember the evidence for Tamil right it clearly showed that it could reduce how long flu symptoms lasted from 7 days to 1 week.
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Alasdair Munro retweetledi
My two paragraph summary of my ignorance about covid, and why I think we should find clever ways to test stuff more.
Tom Whipple@whippletom
I've written about my thoughts, tangentially to the inquiry, on covid post-mortems. About confident maths, lack of confidence, and whether we should experiment on kids (we should). If I ever write about covid again, assume it's a hostage situation. thetimes.com/article/3c7c89…
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@SimRelic Does he address the sweetcorn issue?
People are ignoring the evidence
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@apsmunro Hey doctor, you need to go watch Del Bigtree's TheHighwire.com show. It started today at 11AM it's all about this topic. Watch the first 35 minutes it shows how you guys get it all wrong.
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To see how unbelievably stupid this is, consider the following is equally true
“The statement “vaccines don’t cause people to turn into sweetcorn” is not an evidence based claim because studies have not ruled out the possibility that vaccines cause people to turn into sweetcorn”
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Respiratory PCR testing has exploded since the pandemic, but tests are expensive and sometimes used indiscriminately
We produced a statement for our regional network to help guide testing and improve diagnostic stewardship
piernetwork.org/guidelines-res…
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@N95Anaesthetist It’s not subjective - I explained it cites a paper (which I wrote) which clearly explains many of the factors they subsequently get wrong
That is objectively bad
It is also objectively true that there is no evidence of population level immune damage from covid
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@apsmunro Subjectively awful? Thank you for your opinion. Your subjective assertion that there is zero evidence of long term population-wide immune damage from covid is concerning, especially noting your subspcialty.
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A fantastic interview! Here are two of many key messages:
1. Humanity has never achieved herd immunity through natural infection alone.
2. This idea of using children as human shields to theoretically protect more vulnerable adults is a moral atrocity.
L., MA@leslieleeiii
Here's a special digest version of the latest Struggle Session with Dr. Johnathan Howard (@19joho) where we dispel some prevalent myths about COVID with regards to herd immunity, vaccinations, COVID's long term effects, and the Great Barrington Declaration. Please check it out!
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@N95Anaesthetist This editorial is awful
The second paper they cite is mine, which they clearly haven’t read since it explains most of the things they go on to misunderstand
There is absolutely zero evidence of long term immune damage from covid at population level, it’s a fantasy
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@apsmunro It's no surprise, but you are focusing on the acute illness, not the long-term sequelae.
bmj.com/content/390/bm…
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