David Lye

166 posts

David Lye

David Lye

@davidlye70

Infectious disease doctor, National Centre Infectious Diseases. Professor, Lee Kong Chian Medicine. #HighlyCitedResearcher2025

Singapore Katılım Mart 2014
176 Takip Edilen514 Takipçiler
David Lye
David Lye@davidlye70·
New antibiotics were approved in only a limited number of Asian countries. Countries had a median of 3.5 available new antibiotics, ranging from one to six. Approval lag was three to five years after US FDA approval in most cases. sciencedirect.com/science/articl…
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David Lye
David Lye@davidlye70·
Lest we forget😇 Pandemic science is highly important for preparedness for next major outbreak. Nature is predictable yet unpredictable. Recent MERS CoV France and Nipah India are reminders we must remain alert. linkedin.com/posts/pandemic…
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International Society of Antimicrobial Chemotherap
International Society of Antimicrobial Chemotherap@ISAC_world·
🌍✈️ Just back from a dynamic ISAC Strategy Review in Vravrona, Greece 🇬🇷 Global colleagues united to shape the future of our work in antimicrobial resistance. Engaged minds, bold ideas, and a shared commitment to global health. Grateful to all who made it happen! #ISAC #AMR
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David Lye
David Lye@davidlye70·
Get ready for APCCMI 2025 The largest ID and microbiology conference in Asia Submit your abstract Register Book your flight and hotel See you in the land of smiles in November
International Society of Antimicrobial Chemotherap@ISAC_world

Asia Pacific Congress of Clinical Microbiology and #Infection (APCCMI) is taking place in in Bangkok, Thailand, on 2 – 4 November 2025, co-hosted by the Infectious Disease Association of Thailand (IDAT). Read the latest newsletter⬇ apccmi2025.com/newsletter/pdf…

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David Lye
David Lye@davidlye70·
@edenhelmi But you are probably right. We all know that. Immense harm to patients from unnecessary treatment and missing real diagnosis.
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David Lye
David Lye@davidlye70·
@davidantibiotic The meta analysis even more impressive. All the trials had risk ratio that crossed one, then the meta analysis showed significance for 90 day all cause mortality. The trial is informative. Continuous infusion has marginal clinical benefit.
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David Paterson
David Paterson@davidantibiotic·
BLING-3 results. Primary outcome 90 day all-cause mortality - significant benefit on adjusted analysis.
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David Lye
David Lye@davidlye70·
Please join us by registering with Zoom link and share to your network to learn more about Nipah from @linfa_wang, severe fever with thrombocytopenia syndrome from Professor Dongmin Kim and one health AMR in China from Professor Yonghong Xiao
International Society of Antimicrobial Chemotherap@ISAC_world

📢Webinar announcement We invite you to a collaborative webinar with ISAC Member Society, Asia Pacific Society of Clinical Microbiology & Infection (APSCMI) "One health aspects of AMR and infections in Asia" 📅9 May 2024 Register⬇️ tinyurl.com/5392xrj7 #Onehealth #IDxposts

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David Lye
David Lye@davidlye70·
If multiple airports especially connecting nodes do wastewater surveillance the probability of picking up a novel virus may be significant, a modelling study based on late 2019 early 2020 for SARS2. Lesson for next major epidemic or pandemic. journals.plos.org/globalpubliche…
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David Lye
David Lye@davidlye70·
@SetteLab @bertoletti_lab We just went through a large JN.1. Most patients did not have pneumonia or need oxygen. Most hospitalized were frail elderly with minor illness triggered by a viral infection. Real world empirical evidence supports robust cross protective T cells.
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Alessandro Sette
Alessandro Sette@SetteLab·
Our new study is out! The new Pirola (BA.2.86) and associated variants are cause for much concern. Will this variants escape T cell responses, which contribute to fend off, in the majority of cases, severe disease? sciencedirect.com/science/articl…
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David Lye
David Lye@davidlye70·
104,179 Delta and 375,903 Omicron cases. Higher risk of cognition/memory disorders reported in Omicron and Delta. Delta-variant —> increased anosmia/dysgeusia and psychosis. Omicron-variant —> abnormal involuntary movements. Risk in hospital COVID. clinicalmicrobiologyandinfection.com/article/S1198-…
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David Lye
David Lye@davidlye70·
Optimising antibiotic use to combat antibiotic resistance starts from right clinical diagnosis followed by right microbiology tests to guide antibiotic use. Feel free to share and use this e-learning module to teach medical students, doctors and any prescribers.
International Society of Antimicrobial Chemotherap@ISAC_world

📢NEW Microbiology in Clinical Practice | #Elearning course Sign up for this course by ISAC Member Society, Asia Pacific Society of Clinical #Microbiology and Infection (APSCMI) developed with @biomerieux Access the accredited version ⬇ tinyurl.com/3w3tynw4 @davidlye70

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David Lye
David Lye@davidlye70·
@raynerkjtan Do what you can. I used to do one monthly for reputable journals. Now I only review randomised trials in journals with IF>10. That reduces a lot of work. As young faculty you need time to get grants, do research, publish and give lectures so don’t overdo peer review😉.
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Rayner Tan
Rayner Tan@raynerkjtan·
I received nearly 30 article peer review invitations in Oct 2023. I bet others receive more! At this rate I can only review about 10% of them. Is this sustainable practice for academia? I think journal editorial teams are facing similar issues with shortages of peer reviewers.
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Sean Ong
Sean Ong@seanongwx·
Presenting my poster comparing the cost-effectiveness of adaptive platform trial design vs conventional clinical trial design at #IDWeek2023 — come say hi at poster 378!
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Helmi Sulaiman
Helmi Sulaiman@edenhelmi·
Today, I saw PSSA I cannot believe my eyes Hopefully, Malaysia can join the exciting @snap_trial soon, and help study PSSAB: IV (Flu)cloxacillin vs IV Benzylpenicillin/Penicillin G @DrSyamhanin @adammashraff
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David Lye
David Lye@davidlye70·
@DrToddLee @sebpoule 3B is a lot for city of Quebec…but EPIC has made my outpatient consultations so much better…using smartphrases to pull data…downside is doing the essential clicks but not all clicks are essential
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David Lye
David Lye@davidlye70·
Important lessons: antimicrobial stewardship is a programme like infection control, need multi-pronged approach, adequate resources, ongoing evaluation, respond to emerging issues (like carbapemenases), perseverance. Not overnight wonder.
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David Lye
David Lye@davidlye70·
Ten years of nationally funded antimicrobial stewardship in Singapore public hospitals: less broad spectrum antibiotic use and antibiotic resistant bacteria except beta lactamase inhibitors and carbapenemases. aricjournal.biomedcentral.com/articles/10.11…
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David Lye
David Lye@davidlye70·
@syctong @snap_trial Ok more controversial than I thought: World Bank rates it as UMIC, Wellcome Trust classifies it as LMIC😅
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David Lye
David Lye@davidlye70·
Bivalent Omicron mRNA vaccine reduced medical attendance and hospitalisation vs monovalent as 2nd booster in >18 years with 3 mRNA in Singapore during Omicron. No immune imprinting seen. thelancet.com/journals/lanin…
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Keşfet

@ISAC_world @KanjSouha @JasonJinxin @edenhelmi @davidantibiotic @linfa_wang @SetteLab @bertoletti_lab