Deborah Zarin

361 posts

Deborah Zarin

Deborah Zarin

@DeborahZarin

Katılım Mart 2020
46 Takip Edilen137 Takipçiler
Deborah Zarin
Deborah Zarin@DeborahZarin·
@NaudetFlorian An exceptional article that reveals serious public policy gaps. @FDA: please use NCT #s when referring to clinical trials so that sleuthing is not necessary. And then please link any findings that require regulatory actions to the ClinicalTrials.gov record.
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Florian Naudet
Florian Naudet@NaudetFlorian·
A great paper: "When the FDA finds significant departures from good clinical practice, those findings are seldom reflected in the peer-reviewed literature, even when there is evidence of data fabrication or other forms of research misconduct." jamanetwork.com/journals/jamai…
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Allen Frances
Allen Frances@AllenFrancesMD·
Screening all kids 8-18 for anxiety is dumb/dangerous idea: 1)Causes massive false positive overdiagnosis/stigma/misuse of meds 2)Not enough clinicians to treat kids identified 2)Drains resources better used to improve kid's lives/education 3)Neglects dire needs of severely ill
The New York Times@nytimes

An influential group of U.S. experts has recommended screening all children ages 8 and older for anxiety, saying the latest research supports early intervention for younger kids. More than 7% of children ages 3 to 17 have diagnosed anxiety, the CDC says. nyti.ms/3EcNA0C

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Deborah Zarin
Deborah Zarin@DeborahZarin·
@eturnermd1 Ha! Trial registration provides a public listing of trial existence. That’s how we know that so many trials lack publicly available results. Registration alone cannot fix that—it’s simply a tool that policymakers can use to address results non-reporting
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Deborah Zarin
Deborah Zarin@DeborahZarin·
@TranspariMED Nicely done!! Of course agree that it shouldn’t be your job—but on other hand, ClinicalTrials.gov allows for public accountability—and this what that looks like!
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TranspariMED
TranspariMED@TranspariMED·
Its nice to have rescued the results for 4 paediatric clinical trials from becoming lost forever, but it should not be left to advocacy groups working with unpaid volunteers to ensure this happens. FDA's budget = over 6 billion dollars
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TranspariMED
TranspariMED@TranspariMED·
Where is the #FDA when children need it? Act 1. Company runs 4 clinical trials involving kids Act 2. Company fails to publish results as required by federal law Act 3. TranspariMED contacts company (FDA apparently never did this) Act 4. Company publishes all 4 results
TranspariMED tweet media
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Deborah Zarin
Deborah Zarin@DeborahZarin·
@eturnermd1 @markhoro Ugh. Registration in designed to prevent unacknowledged changes to prespecified outcome measures—but editors (along with reviewers) must check—and require explanations for any discrepancies! Registration isn’t magic…
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Mark Horowitz @markhoro.bsky.social
Mark Horowitz @markhoro.bsky.social@markhoro·
As a reprieve from the usual pharma-positive spin from the SMC (which has drug companies as major donors) Assoc Prof Das makes some very useful points about this psilocybin study, including increased suicidality in the psilocybin group: shorturl.at/fpAN6
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Peter B. Bach, MD
Peter B. Bach, MD@peterbachmd·
So last week I was at CHEST, a meeting of respiratory docs and < 5% in masks. Now I am at #SMDM22 , a meeting of experts in tradeoffs, spillover effects and social welfare, and 90 pct in masks. I feel like there is a learning here.
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Deborah Zarin
Deborah Zarin@DeborahZarin·
@NDevito1 @TranspariMED @FDACommissioner I don’t know about this particular trial, but. in general, the trials are done at academic medical centers—and the patients probably think of the AMC as endorsing the trial. So they are also complicit. In my mind—not legally
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Nick DeVito
Nick DeVito@NDevito1·
We probably want to know what studies @purduepharma sponsored about opioids say, right? Well what about this one? (Thread)
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TranspariMED
TranspariMED@TranspariMED·
U.S. Senators demand rapid disclosure of all NIH clinical trial results -> finally policy makers are waking up to the immense cost of federally funded research waste in medicine transparimed.org/single-post/se…
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David Zipper
David Zipper@DavidZipper·
Belfast and Edinburgh reduced their speed limits from 30 mph to 20. The result: "The main outcome of these schemes was a reduction in road casualties at all levels of severity." pubmed.ncbi.nlm.nih.gov/36173872/
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Michael L. Barnett
Michael L. Barnett@ml_barnett·
Great exposé of the Medicare Advantage grift. Any wonder that the "hottest" heath care startups are just fancy MA plans? Fraud in MA could be as large as the budget of the FBI, EPA and federal prison system combined. thanks @sangerkatz @ReedAbelson nytimes.com/2022/10/08/ups…
Michael L. Barnett tweet media
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Joseph Ross
Joseph Ross@jsross119·
Seems like a terrible idea. We want Congress to give regulatory agencies the authority to make decisions - esp those that impact public health - using best science/evidence, not to be hamstrung when Congress is unhappy with the decisions. pharmaphorum.com/?p=99430 via @pharmaphorum
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Holly Fernandez Lynch
Holly Fernandez Lynch@HollyLynchez·
3. AMX0035: 1 study, stat sig results re: fxnl decline on co's analysis not FDA's, survival benefit in OLE I get excitement for another option+hope this 1 works. But note this is the assortment of tx options produced by low FDA approval standards. 2/2 accessdata.fda.gov/scripts/cder/d…
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Nick DeVito
Nick DeVito@NDevito1·
I guess if I ever got my Italian citizenship that opens up the rest of Europe but they all seem pretty eager to elect their own fash parties!
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Nick DeVito
Nick DeVito@NDevito1·
So I live in the UK which seems to be undergoing a slow motion self-imposed economic collapse, am a U.S. citizen which lol, and am eligible for Italian citizenship which just elected the fash sympathizer party. Options rapidly dwindling.
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David Enrich
David Enrich@davidenrich·
Today the @nytimes is publishing the first two installments in a series called "Profits Over Patients." It's about how tax-exempt hospitals have strayed from their charitable missions for the sake of fatter profits – with profound consequences for the US healthcare system. 🧵
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Richard Sever
Richard Sever@cshperspectives·
"the distance between the raw data set and the analytic data set is huge" @hmkyale at #cziopensci makes a point critical to consider in the context of data mandates i.e. What do they mean by "the data"?
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Rita Redberg
Rita Redberg@RFRedberg·
The return on investment to the drug industry of FDA user fees is in billions of dollars. PDUFA is all about how fast can FDA approve drugs, and not about if they help patients. @FDA_Drug_Info F.D.A.’s Drug Industry Fees Fuel Concerns Over Influence nytimes.com/2022/09/15/hea…
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Keşfet

@NaudetFlorian @FDA @TranspariMED @markhoro @NDevito1 @FDACommissioner @purduepharma @sangerkatz