Barbara De Kegel

34 posts

Barbara De Kegel banner
Barbara De Kegel

Barbara De Kegel

@dekegelb

Computational scientist in the Cancer Data Science team @BroadInstitute; PhD from @UCDdublin

Boston Katılım Eylül 2018
151 Takip Edilen128 Takipçiler
Barbara De Kegel retweetledi
Colm Ryan
Colm Ryan@colmr·
delighted to see @dekegelb's work out in @MolSystBiol! Tumors tolerate astonishing numbers of genetic alterations, including homozygous deletion of entire protein coding genes. How? Here we explored one potential explanation – paralog dispensability! embopress.org/doi/full/10.15…
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David Adams
David Adams@David_J_Adams·
what do people feel are the best "on-target" / "activity", off-target" scorers/methods/packages to retrospectively analyse library gRNAs?
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Barbara De Kegel retweetledi
Colm Ryan
Colm Ryan@colmr·
the lab will be well represented at #ESB22 this week, with a poster from @dekegelb on Thursday and a talk from @AnjanVenkatesh on Friday
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Barbara De Kegel retweetledi
Colm Ryan
Colm Ryan@colmr·
an updated version of @dekegelb's work predicting synthetic lethal interactions between paralogs in cancer. our focus was always on predicting robust synthetic lethals (those that operate across multiple cell lines) but now we clarify why that's important biorxiv.org/content/10.110…
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Barbara De Kegel
Barbara De Kegel@dekegelb·
@Muller_Lab We didn't test NMNAT1:2 and NMNAT2:3 in our analysis to derive the bronze standard - they didn't pass the filtering steps while NMNAT1:3 did. We've only considered pairwise SLs so far - it's likely there are triplets but they're much harder to detect (w/ existing data)/predict!
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Muller Lab
Muller Lab@Muller_Lab·
@dekegelb Thanks, I saw. Studying them right now. What made you come to the determination that NMNAT1:3 but not not NMNAT1:2 or NMNAT2:3 are SL? I would love to see what you guys predict for triplets - cases where 3 paralogues are present and similarly expressed?
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Muller Lab
Muller Lab@Muller_Lab·
Nice story - trying to find supplementary tables. Are they missing?
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Barbara De Kegel retweetledi
Colm Ryan
Colm Ryan@colmr·
for those attending #CRISPR20, @dekegelb will be presenting at this afternoon's session on genetic interactions, discussing paralogs & synthetic lethality in cancer
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Barbara De Kegel retweetledi
Colm Ryan
Colm Ryan@colmr·
delighted to see this paper with @Boiley and @IcrLordLab out in @eLife elifesciences.org/articles/58925. For those who missed the preprint tweetorial, here goes again! For over a decade people have been trying to identify new synthetic lethal interactions using loss of function screens
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Keşfet

@MolSystBiol @David_J_Adams @IrishResearch @colmr @sysbioire @UCDCompSci @UCD_Research @Boiley