DidierResearchGroup

Excited to share our latest work on 4-to-5 skeletal editing towards halogenated pyrroles, and first 1st author paper for Rahma! Congrats 💪 chemrxiv.org/engage/chemrxi…

Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv (chemrxiv.org/engage/chemrxi…) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their requisite catalysts) or potentiostats for electrochemistry. Now, such transformations can be accomplished with the same ease that one conducts a Suzuki coupling. You can scale up (its homogeneous) or scale down (use cheap parallel screening plates). Moisture is tolerated and base metal catalysis is used. As the best engineers like to say, "The best part is no part". Now, chemists have the option to remove the redox part from radical couplings. Quick Summary: Sulfonyl hydrazides are disclosed as versatile radical precursors as exemplified with seven new C–C bond forming, redox-neutral cross-couplings with: (1) activated olefins, (2) alkyl halides, (3) redox active esters, (4) aryl halides, (5) alkenyl halides, (6) alkynyl halides, and (7) a trifluoromethylating reagent to forge C(sp3)-C(sp3), C(sp3)-C(sp2), and C(sp3)-C(sp) bonds. Sulfonyl hydrazides are stable and usually crystalline substances that can be accessed in a variety of ways including transiently from hydrazones to achieve a net reductive arylation of carbonyl compounds. Exogenous redox (chemical, photo/electrochemical) additives are not necessary as these functional groups serve the dual role of radical precursor and electron donor. The operational simplicity (homogeneous, water tolerant, dump-and-stir) and practicality of the method are demonstrated as well as applications to streamlining synthesis and mild late-stage functionalization.

I/Zn exchanges have never been so easy. With our new reagent: 15min, rt. Alkene vs. Aryl selectivity, broad scope, great functional group tolerance. Functionalization of nucleotides, glycals, cyclobutenes, and much more. Preprint online now: chemrxiv.org/engage/chemrxi…

@BaranLabReads @ChemRxiv Love the pictogram for Co 😉

Anomeric Nitroamide Enabled, Cobalt Catalyzed Alkene Hydronitration: Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxi… Tertiary nitroalkanes, as well as its reduced products, α-tertiary amines, play an essential role in drug discovery either as key synthetic precursors or final incorporation in targeted molecules. Existing methods to prepare tertiary nitro compounds generally rely on polar-bond disconnections, in which strong bases or highly active electrophiles are needed. Here, we report the development of an anomeric nitroamide-based reagent that enables exquisitely selective MHAT-based Co-catalyzed alkene hydronitration for the preparation of valuable tertiary nitro compounds. This mild, scalable reaction shows broad functional group tolerance, is applied to a variety of structures. Late-stage nitration of complex contexts (9 examples) derived from drugs and natural products is also pursued. Its high prowess is further highlighted in simplifying the synthesis of a rare naturally occurring nitro sugar. Simple access to isotopically labeled 15N-containing nitro compounds is also disclosed. The anomeric nitroamide reagent was deemed safe by energetic measurements and its unique reactivity rationalized based on X-ray crystallographic analysis.

This provides a straightforward access to glyflosins, for example… chemrxiv.org/engage/chemrxi…

Excited to share a story that started before the pandemic and was on standby during our moving: Zweifel olefination for C-glycosylation - an alternative route towards C-glucosides, -rhamnosides, -xylosides and -arabinosides. Congrats to Flo and Bilel (also his first paper!)

One man's trash🗑️=another man's treasure🪙Selectfluor: world's🌍favourite fluorinator(?), yet we throw away 95% its MW. Adding the same waste at the start promotes radical fluorinations to higher rates & yields (~3x) by a reactive heteroaggregate w/SF⛓️💡 tinyurl.com/yvv62fex

.@didier_group report a one-pot synthesis of stereo-defined trisubstituted azetidines, cyclobutanes, and five-membered carbo- and heterocycles based on the polar radical crossover of borate derivatives. nature.com/articles/s4200…

Excited to share our latest contribution to small-ring functionalization, this time using stereoselective radical-polar crossover processes. First contribution since we moved from Munich to Darmstadt. Congrats Flo and @RahmaGhazali2 for the team effort. nature.com/articles/s4200…

Hey peeps, If you (or someone you know) is interested in doing a postdoc in the field of asymmetric bio-hybrid catalysis or asymmetric palladium catalysis, the 2024 #MSCA call is open. I’d be happy to host you @Chemistry_QMUL Please share… …sklodowska-curie-actions.ec.europa.eu/calls/msca-pos…

@Johnjmol @NeilJudge1 @J_A_C_S @funes_ardoiz @peterseeberger @MpiciPotsdam Congrats John, that’s a nice piece of work!

Delighted to share our recent work "Photogeneration of α‑Bimetalloid Radicals via Selective Activation of Multifunctional C1 Units" published in @J_A_C_S. An amazing effort from Lewis, Alessandro, Patrick @funes_ardoiz @peterseeberger @MpiciPotsdam pubs.acs.org/doi/10.1021/ja…

@Dr_Berionni Mont Saint-Michel ?

Window with a view. Guess where?

@ATlili1 Félicitations Anis ! C’est bien mérité

@LcsoLab @EPFL_CHEM_Tweet Thanks again for the invitation @LcsoLab , I had a great time there @EPFL

Organic seminar again @EPFL_CHEM_Tweet with Prof Dorian Didier @didier_group from TU Darmstadt: it is boron time!

Congrats Chris! Have a great start.

Main Group Metal Chemistry Symposium in Nancy, thanks for the invite!

"Ich gratuliere den Kollegen Alexander Friedrich und Andreas Dreizler sehr herzlich zur Auszeichnung mit zwei ERC Synergy Grants! Die beiden Projekte stehen beispielhaft für wesentliche Charakteristiken und Stärken der Forschung an unserer Universität: 1/3

We have an open postdoctoral position in our group in Bayreuth (shoubhikdas.uni-bayreuth.de). Experience in catalysis (Photo-, electro- or thermo-) is an advantage. Please send your application with a cover letter and a cv by 15 th of October.

Recent Progress in Zweifel Olefination: An Update (@thiemechemistry): thieme-connect.com/products/ejour….