Erik Wright

Congratulations to Aidan in our lab on the publication of his tool EvoWeaver: nature.com/articles/s4146… tl;dr Partial biochemical pathways derived from genome information alone.

Protein structure search is becoming evermore popular. But I've always wondered whether some structure matches arise from convergent evolution. Now we know the answer – a resounding yes! This has major implications for the use of protein structure search. academic.oup.com/gbe/article/17…

Years of effort culminating into an excellent paper by Sam Blechman from our lab: journals.plos.org/plospathogens/… tl;dr MRSA infections are commonly treated with the antibiotic vancomycin. Yet MRSA almost never gains resistance. Now we known why vancomycin is so durable against MRSA.

Congrats to Sam for his publication reviewing the intersection of EHR mining, machine learning, and antibiotic resistance! @JIDJournal doi.org/10.1093/infdis…

DECIPHER v3 released yesterday with lots of new features! Time to update: bioconductor.org/packages/relea…

The Wright Lab has a new website! I think it's the coolest lab website ever, but don't trust me: wrightlabscience.com Many thanks to Monica in our lab for catching us up to 2024! 😎

It turns out a lot of pseudogenes are actually genes. See our new publication in BMC Genomics. bmcgenomics.biomedcentral.com/articles/10.11… The extent of this problem in public genome databases is mind blowing! Congratulations to Nick in our lab for figuring this out.

Clusterize is now published in Nature Communications. nature.com/articles/s4146… Clustering large numbers of sequences accurately in linear time via relatedness sorting. Check out the accuracy relative to MMseqs, CD-HIT, etc.!

So proud of my lab for this new publication in a completely different area of research for us! #Abs1" target="_blank" rel="nofollow noopener">bmcpublichealth.biomedcentral.com/articles/10.11… And especially proud of this creative infographic created by our newest lab member!! wrightlabscience.com/index.html

Happy to see Travis' work in our lab out in print. An important read if you are doing #microbiome studies. bmcmicrobiol.biomedcentral.com/articles/10.11…

We need a plan D (for Data!) nature.com/articles/s4159…

Excited this collaboration with @SCOTTeHENSLEY and Drew Weissman is out. Cool work in broad flu mRNA vaccines. Work on ferrets from my lab was done by @SageVle

Clever method for getting rid of the thermocycler in PCR: nature.com/articles/s4146…

Balancing Trade-Offs Imposed by Growth Media and Mass Spectrometry for Bacterial Exometabolomics @AppEnvMicro from @digitalwright journals.asm.org/doi/10.1128/ae… journals.asm.org/doi/10.1128/ae…

Very cool work on a conundrum in evolution: How to cross between fitness peaks? Many fitness landscapes have paths between peaks that circumvent valleys: nature.com/articles/s4155…

Congratulations to Jennifer Brennan for her new paper in @PLOSCompBiol journals.plos.org/ploscompbiol/a… In this collaboration with the @kgjamieson lab, we show how to easily find synergies among many drugs. Synergies among combinations of up to 8 antibiotics were rare for 𝐸. 𝑐𝑜𝑙𝑖.

@naturemethods More proof the 16S gene is insufficient for species level resolution: microbiomejournal.biomedcentral.com/articles/10.11…

Another day, another paper claiming to give species level resolution from the 16S gene, in @naturemethods: nature.com/articles/s4159… See plot of correlation between 16S and genome divergence: link.springer.com/article/10.118… Two bacteria with identical 16S can share 50% of their genes!

🦇 Some moths have evolved to produce ultrasound capable of jamming bat sonar pnas.org/doi/full/10.10…

This mind-blowing research in @Nature shows that machine learning can effectively guide enzyme optimization and help create enzymes that degrade all kinds of plastic waste in record time 🤯nature.com/articles/s4158…