Dirk Paul

From @sangerinstitute and the CEU! Translating genetic changes into future health impact New resource helps bridge the gap between identifying genetic changes linked to health conditions & understanding how these changes impact biological processes 🔗tinyurl.com/3fs4prt3

Five years on, few Britons think Brexit has been good for anything % saying Brexit has had a positive impact on... Control the UK has over its laws: 31% UK's ability to respond to COVID-19: 23% British politics: 12% UK's level of international trade: 11% British businesses: 11% UK diplomatic influence in the wider world: 10% National security: 10% The economy: 10% Yourself personally: 8% Public finances: 8% Strength of the Union: 7% NHS: 6% Tourism from Europe > UK: 6% UK diplomatic influence in Europe: 6% Immigration levels: 6% Tourism for Britons > Europe: 5% Cost of living: 5% Crime: 4% yougov.co.uk/politics/artic…

📣Excited to share our paper in @NatureGenet! rdcu.be/d7mo0 Do plasma proteins mediate obesity’s effect on CAD risk? →Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin as a mediator & potential therapeutic target A 🧵

Today we’re launching the world’s most comprehensive study of proteins circulating in our bodies, which will transform research into new medical tests, drugs and treatments. Discover more: ukbiobank.ac.uk/learn-more-abo…

If you’re thinking about voting Reform, remember that they made you poorer.

Can genetics affect our iron levels and what impact can this have on our health? @eliasallara and colleagues explored how the body controls iron and highlight how having too much or too little can negatively impact health Read more here 👉 tinyurl.com/h5yk3sfb

Dr. @dirk_paul's study on cell type-specific roles in cardiovascular disease highlights the critical insights made possible by us. Find out about more researcher stories and our involvement: ow.ly/t2Lb50UocIf

@ee_davenport @TVanderstichele @nickywhiffin @ewanbirney @LeopoldParts Congratulations, Thomas! 🎉🤩 Well done!!!

Congratulations Dr @TVanderstichele on your successful PhD viva! Our second PhD student. Huge thank you to his examiners (@nickywhiffin and @ewanbirney), and his other supervisors (@LeopoldParts and Adam Platt), our team and our collaborators for all the support.

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi

Last autumn FinnGen hit its target of sampling close to 10% of the Finnish population with more than 500,000 participants. We are happy to announce that the results based on the full cohort are now publicly available for the whole research community: finngen.fi/en/results-bas…

Among British S Asians (individuals ancestrally from Bangladesh & Pakistan living in East London), a missense variant in PIEZO1 (MAF 3.9%, but very rare in non-SAS) leads to lower HgA1c & thus delayed T2D diagnosis nature.com/articles/s4146… @NatureComms

Want to use a cardiovascular disease🫀risk score for primary prevention, but unsure which is the best for your population?🧐 Our work compares CVD risk scores & provides a framework for selecting the most appropriate score. Just out in @LancetGH!👀⬇️ doi.org/10.1016/S2214-…

NEW: we may have passed peak obesity 🎉📈📉🙏 In what might be one of the most significant trends I have ever charted, the US obesity rate fell last year.

"'Gene misbehaviour' widespread in healthy population" a fascinating joint study from researchers @aidanbutty @minouye271 @Di_Angelantonio @JohnNDanesh @dirk_paul led by the @sangerinstitute spreaker.com/episode/gene-m…

Out today in @NatureGenet! Important new updates to the Polygenic Score (PGS) Catalog, & a new software tool that simplifies the calculation of polygenic scores in the context of genetic ancestry 👉 tinyurl.com/fa5ts5a3 @iamslambert @minouye271 @sritchie73 @Florent_Yvon

There is a huge need to understand how BMI affects long term multiple long terms diseases. This PhD is jointly with the University of Cambridge and AstraZeneca.

Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded studentship w/ @MikeXiao_JIANG 🔗: jobs.cam.ac.uk/job/48333/ (due October 31)! @CAMBRIDGE_CEU @HLRI_Cambridge @Cambridgecardio @DPHPC @CambridgeATS

New online! A review of polygenic scores and their applications in kidney disease from @atlasmaths and @kirylukk go.nature.com/3zjRC9p

New research in Nature Genetics introduces MILTON, a cutting-edge machine-learning research tool that accelerates drug targets and biomarkers discovery, with potential to redefine the landscape of preventative health care: learn.az/6017WsgZD

ASCI members Krzysztof Kiryluk @kirylukk and Ali G. Gharavi @Columbia evaluate 3 cohorts and find monogenic kidney disorders are associated with an increased risk of kidney failure, higher eGFR decline rate, and lower rates of complete remission: buff.ly/3XBriRh