Atlas Khan

eMERGE returned PRS/Fam Hx/Mono results to n=23,840, 35% hi-risk for ≥1 of 11 diseases. Note: 1) high burden of genetic risk for common disease; 2) large-scale genomic risk assessment is feasible; 3) equity challenges must be addressed for implementation doi.org/10.1016/j.ajhg…

Then, from Lawson & co 📰Return of genome-informed risk-assessment results for common conditions to 23,840 adults and children: An eMERGE network study cell.com/ajhg/abstract/…

First, from Limdi et al 📰The Electronic Medical Records and Genomics study: Design and analytic framework for assessing the impact of genome-informed risk assessments cell.com/ajhg/fulltext/…

This #ASNKidney360 study explored how iron deficiency affects kidney development, focusing on the role of transferrin receptor (TfR1) and non-transferrin-bound iron (NTBI). Read more and explore #BasicResearch: kidney.pub/KID1064

@MeFaheem Or 'best hopes'

@MeFaheem I follow you to get news about my KP, but you only has “best wishes.” It’s so sad that these days it is very difficult to find sincere people, because everyone just has “best wishes” in their hearts.

پشاور ہائی کورٹ نے جس طرح آئین اور قانون کی بالادستی کی اور پھر بلاول بھٹو زرداری نے آئین کی پاسداری کا سبق انتہائی نرم لہجے میں گورنر خیبر پختونخوا فیصل کریم کنڈی کو پڑھایا اس سے امید پیدا ہوگئی ہے کہ خیبر پختونخوا میں محمد سہیل آفریدی کی حکومت مستحکم ہوگی

@MeFaheem I think you are doing much better than them, so good luck!

سیاسی قانونی اور عملی میدان پی ٹی آئی نے شائد پہلی مرتبہ تینوں محاذوں پر بہترین سیاست کی ہے اب کامیابی کتنی ملے گی یہ کل معلوم ہوگا

#Genetic studies of #hair traits that vary within and across populations create opportunities to generate new clinically relevant knowledge about physiology that is fundamental to human #health and #medicine authors.elsevier.com/sd/article/S00…

GWAS highlights the neuronal contribution to multiple sclerosis susceptibility #multiplesclerosis #journals #articles More info | ⬇️ buff.ly/3OIWJ7e

Come check out (and support) the @ASNKidney #KidneyWk debut of Elena Martinelli @Martinelli_Elen from our lab, presenting new data following up on the role of the #APOL1 protective M1 variant as a potential important test to help guiding accurate diagnosis for different forms of kidney disease. Including data from @CureGn, NEPTUNE, @ColumbiaMed , @MassGenBrigham Biobank, @uk_biobank , eMERGE, PAGE, and @AllofUsResearch #FSGS #CKD #RareDisease @kidneyomicsamps @GbadegesinLab @TheSampsonLab @rFSGSInitiative @nephcure @ISGDtweets @NephroticSyn @GlomCon @CUIMCGlomCenter @NephroticF @RareDiseases @ApolloNetwork13 @H3Africa @AfricanAFRAN @m_t_mcnulty @atlasmaths @kirylukk @UMaggiore @GuptaYask @tzeyinlim @JMartinoActual @janewitwong @pnatarajanmd

@KSusztak Agreed but how to make big discoveries without grants.

I very much see this trend. Most people talk about writing or getting large grants. I am driven by the curiosity creativity and the joy of discovery that science brings- wish that stays priority.

@KSusztak Happy birthday!!!

Want to delay aging ? Just celebrate your birthday one month late ! Thanks for my awesome lab. Next birthday 🎂 is October 2025 !

New online! A review of polygenic scores and their applications in kidney disease from @atlasmaths and @kirylukk go.nature.com/3zjRC9p

Exciting news indeed! Congrats @CPMGatColumbia '@sarathbabu_k @HilaMilo @kirylukk @joshuamotelow @JoshuaEMotelow @atlasmaths @SpringerNature (link.springer.com/article/10.100…)

@sarathbabu_k @CPMGatColumbia @SpringerNature Great work!!!

Exciting news! Our team @CPMGatColumbia 's paper describing a novel methodology to identify small genomic regions with a high frequency of insertions and deletions (indels) has been published in Functional & Integrative Genomics @SpringerNature (link.springer.com/article/10.100…)

A new study from the eMERGE consortium reports on a pipeline for the generation and reporting of polygenic risk scores for ten diseases to diverse populations in a clinical setting @nialljlennon @EimearEKenny @AllofUsResearch @broadinstitute nature.com/articles/s4159…

@kidneyomicsamps Great, happy holidays

@Biomaven @doctorveera 41k SNPs!!!

@doctorveera How many SNPs in the polygenic risk score?

Nice study showing polygenic risk alters the penetrance of monogenic kidney disease. This will be the norm in every disease, but nice to see the satisfying results. Note the striking difference between high (OR=54.4) vs low (OR=3.03) PRS groups among rare variant carriers. Amazing Khan et al. Nat Comm nature.com/articles/s4146…