DMT Quest

DMT Quest Documentary (Full Episode #1) @elonmusk @joerogan @Graham__Hancock @DennisMcKenna4 @alexgreycosm @AubreyMarcus @BeckleyResearch

Researchers at the Institute for Basic Science (IBS) in South Korea have identified a non-invasive technique to significantly enhance the brain's waste clearance mechanism. By applying gentle mechanical stimulation to the skin overlying lymphatic vessels in the face and neck, they dramatically increased cerebrospinal fluid (CSF) outflow in mice—effectively doubling drainage in many cases and fully restoring impaired clearance in aged animals to youthful levels. This approach relies on a custom force-regulated mechanical device that lightly compresses and strokes the skin, targeting superficial cervical lymphatics without interfering with their natural contractions or requiring drugs or invasive procedures. The stimulation boosts CSF flow through previously underappreciated drainage pathways that connect the brain to superficial lymph nodes via facial, nasal, and palatal lymphatic networks—routes confirmed in both mice and primates, with strong implications for potential human relevance. The discovery addresses age-related declines in CSF drainage, which contribute to the buildup of toxic proteins like amyloid-β and tau associated with Alzheimer's disease and other neurodegenerative conditions. By reversing drainage deficits in older mice, the method offers a promising proof-of-concept for improving brain health in aging populations. The researchers emphasize that this remains preclinical work conducted in animal models, and human translation will require further studies to assess safety, optimal protocols, long-term benefits, and efficacy against diseases like Alzheimer's. Nonetheless, the findings suggest exciting possibilities for developing simple, wearable, or clinical devices—perhaps akin to targeted facial massage tools—to support natural brain detoxification and potentially slow neurodegeneration. [Jin, H., Yoon, J.-H., Hong, S. P. et al. (2025). Increased CSF drainage by non-invasive manipulation of cervical lymphatics. Nature. DOI: 10.1038/s41586-025-09052-5]

>200 million people have peripheral artery disease (PAD). In its worst form, blood vessels fail to regrow after surgery. Wounds stay open. Muscles waste. @HaoYin20's preregistered proposal just received $10k to study the pathology of PAD on ResearchHub. 🧵

Happy 20th anniversary to the greatest St. Patrick’s Day video on the Internet.

Students who took notes by hand scored ~28% higher on conceptual questions than laptop note-takers. Writing forces your brain to process and compress ideas instead of copying them.

Your brain peaked musically somewhere around age 16. Everything since then has been a dopamine echo. Between the ages of 12 and 22, the mesolimbic dopamine pathway, the same circuit that processes cocaine and sex, fires at levels in response to sound that it will never reach again for the rest of your life. A 2011 McGill study used PET scans and fMRI simultaneously and found that music triggers dopamine release in the striatum at peak emotional arousal. The caudate nucleus lights up during anticipation of the good part. The nucleus accumbens lights up when it hits. Your brain is treating a guitar riff with the same reward architecture it uses for food-seeking and pair bonding. During adolescence, that response is dramatically amplified. Pubertal hormones are flooding the system. The prefrontal cortex is still wiring itself. Memories formed during this window get encoded with a density of emotional tagging that nothing in your 30s or 40s can replicate. Researchers at the University of Leeds identified this as the “reminiscence bump”: the period when your sense of self is forming, and the music playing during that formation becomes structurally integrated into your identity. A 2025 longitudinal study from the University of Gothenburg analyzed 40,000 users’ streaming data across 15 years. Younger listeners explored broadly across genres. Older listeners collapsed into increasingly narrow loops, almost entirely anchored to music from their teens and early twenties. Your brain stopped losing interest in new music years ago. It’s running a cost-benefit analysis. Familiar songs deliver guaranteed dopamine with zero processing cost. New songs require pattern recognition, expectation-building, and repeated exposure before the reward circuit kicks in. Past 25, most people stop paying that tax. The one variable that predicts whether someone keeps exploring: the personality trait “openness to experience.” Score high, you keep seeking. Score average, you default to the familiar forever. The fix, if you want one: deliberate exposure. Three listens minimum before your auditory cortex builds enough predictive models to generate a reward response. One passive listen on a playlist will never get there. Your brain needs repetition to find the pattern, and it needs the pattern to release dopamine.

Elon Musk: “Look fear straight in the eye, and it will disappear.”

Memory loss doesn’t start in your brain. 2 days ago, Stanford published a study in Nature identifying the exact 3-step pathway: Step 1: Aging shifts your gut bacteria (P. goldsteinii overgrows) Step 2: These bacteria produce fatty acids that trigger IL-1β inflammation in the gut Step 3: Inflammation silences your vagus nerve → hippocampus stops forming memories They transferred old gut bacteria into young mice. The young mice became forgetful. They stimulated the vagus nerve in old mice. Cognitive performance matched young animals. The lead researcher called the gut “a remote control for the brain.” (DOI: 10.1038/s41586-026-10191-6): This flips everything we assumed about aging brains. You’re not losing your edge because of age. You’re losing it because your gut is inflamed and your brain can’t hear its own body anymore. Fix the gut. Get sharp again. Brain fog. Belly fat. Fatigue that sleep doesn’t fix. These aren’t 3 problems. They’re 1 broken pathway. Take my free 2-minute gut assessment quiz to find out where yours is broken. Comment LEAK.

One of my family members works at a hospital and told the following story from the psychiatric ward Patient tells nurse "I saw you last night" "How? I wasn't working last night, and you haven't left the ward" "No, I saw you sitting and reading, you were wearing a red sweater sitting on a brown leather couch" Patient was describing exactly what she was doing at home the night before, with no way of having known Many such cases

New research reveals that psychedelics don't just rewire the brain—they physically repair the "neural insulation" needed to sustain long-term PTSD recovery. ow.ly/MMPf50YpAaI

Random... Is my Tesla Conscious? What is going on here? endohuasca.com/p/is-my-tesla-…

New Science: Exercise Sends Brain-Cleaning Messages from Muscle A new Nature Aging (2026) study reveals a surprising mechanism explaining why exercise helps protect the brain in Alzheimer’s disease. Key discoveries: 1. Exercise makes muscles release extracellular vesicles (SKM-EVs) During swimming exercise, skeletal muscles release tiny signaling particles into circulation. 2. These vesicles travel from muscle to brain Microglia, the brain’s immune cells, take them up through pinocytosis. 3. Microglia become better at clearing amyloid plaques SKM-EVs push microglia into a disease-associated state that boosts removal of toxic amyloid-beta. 4. A key molecule drives the effect: miR-378a-3p This microRNA regulates lipid metabolism in microglia by targeting p110α. 5. Therapeutic potential confirmed in mice Extracellular vesicles from miR-378a–overexpressing muscle cells improved cognition in Alzheimer’s mice Exercise is not just movement. Your muscles actively send molecular signals that help the brain clear Alzheimer’s pathology. The future of Alzheimer’s therapy might look like exercise in a molecule.

My parents are 85 and 87 years old. Yet they're on zero medications, living independently in their 4-story home and even learning new skills like AI. Here's how (the 7 things they do to stay healthy, sharp and thriving into their late 80s):

Repetitive negative thinking is associated with the accumulation of Alzheimer's dementia protein in the brain. Stay positive.

@EO_Nutrition @C02isG00D Works for breathing breatheright.com/breathing-issu…

@C02isG00D 2 years in orthodontics has prepared my occlusion for surgery. No turning back now Want to finally be able to breathe at night

I'm having double jaw surgery in a few months Recovery can be slow and brutal I am currently designing a recovery stack, and want to know which peptides might help Anyone got any recommendations? I'm thinking: - P-15 - KLOW blend - Ipamorelin

Seems important and underutilized pubmed.ncbi.nlm.nih.gov/24398162/

In real-time everywhere now accelerated

If you want true longevity take salvia I spend several thousand years as a wooden chair

Just published: our RCT shows psilocybin (magic mushrooms) dramatically beats nicotine patch for quitting smoking using the same psychotherapy! A single psilocybin session showed 6x greater odds of staying quit. Biologically verified. In @JAMANetworkOpen Thread 🧵 #Psychedelics #QuitSmoking

@9mmsmg @SteelHeart Already done it businessinsider.com/bryan-johnson-…

@SteelHeart It's about the only thing that could.

I don't think there's much out there that can fix Bryan, but if there is, it's 5-Me0-DMT. Nothing is like it on earth. The strongest N,N DMT breakthrough experience can't touch it. I sat drinking Ayahuasca in the jungle puking for three nights, and on the fourth night, we were given 5-MeO. I was an outwardly Christian agnostic (the best way to explain it), and this experience made me believe more than I can explain. It was a life changing experience. Bryan, please don't ruin this by being weird about it. This is a lot different than mushrooms and traditional DMT. You aren't going to experience distortions or introspective thoughts. You are going to go into a white out and experience death. It is traumatic, you will be terrified, and then once you accept it, everything changes forever.