Doudou Yu

Sleep, diet, and stress regulation are key to healthy aging but often decline early. We studied how the hypothalamus, the brain's control center for these functions, changes in normal aging & Alzheimer's (AD). Our HypoAD story 🧵: doi.org/10.1101/2025.1…

Our paper is now out! nature.com/articles/s4158… A big question: 1) Is IT cortex well described as a general-purpose feedforward DNN? OR 2) Are face patches genuinely specialized for processing faces? Read on to find out the answer. (1/N)

@Orr_Lab @HabilZare 9/ Hypothalamus: Alex Jackson @JacksonLabUConn Neuropathologist: Ivana Delalle Computational biology: Ghulam Murtaza, Ritambhara Singh, and Bill Noble And the entire @TheWebbLab, especially Kelsey Babcock @kels_babcock, and Kaitlyn Hajdarovic

8/ This work was a massive team effort and would have been impossible without our amazing collaborators: Imaging: Andrei Vlassenko, Manu Goyal, and Jürgen Germann Senescence: Shiva Dehkordi, Miranda Orr @Orr_Lab, and Habil Zare @HabilZare

Sleep, diet, and stress regulation are key to healthy aging but often decline early. We studied how the hypothalamus, the brain's control center for these functions, changes in normal aging & Alzheimer's (AD). Our HypoAD story 🧵: doi.org/10.1101/2025.1…

🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock⏰ @Nature nature.com/articles/s4158… We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain🧠 Led by @EricDSun; awesome collaboration w/ @BrunetLab 🧵

Thrilled to share our paper online @Nature (on my birthday)! We've identified a new population of LepR neurons (BNC2) in the hypothalamus ARC that acutely suppresses appetite by directly inhibiting AGRP neurons, decoding the missing LepR GABAergic neurons. nature.com/articles/s4158…

Can we use CRISPR screens to identify genes that drive neural stem cell aging? Super excited to see this work published @Nature! Huge congrats to Tyson @ruetz_tyson, Angie Pogson, @kashiwagi_chloe, and all authors! Great collaboration with @MCBassik! nature.com/articles/s4158…

What causes Alzheimer’s disease? Scientists are searching for the answer. It’s likely a combination of brain changes, genes, and factors related to health, the environment, and lifestyle. Learn more: go.nia.nih.gov/3WIVrhB #NIAAlzheimers

🎉 Thrilled to share our latest method, IRIS, now published in @naturemethods！IRIS is a robust statistical and computational method designed to decode the spatial organization of tissues. It efficiently detects biologically interpretable spatial domains across multi-samples.

Beyond thrilled to share 3 papers on the killifish from our lab and fantastic collaborators!! 🐟🙌 Two on protein aggregates during aging – with @JaroszLab! cell.com/developmental-… cell.com/cell-reports/f… One on evolution of 'suspended animation'! cell.com/cell/fulltext/…

Excited to announce the inaugural AIMBA (AI Meets Biology of Aging) 2024 meeting on May 22, 2023, 9-2pm PT, organized by @UW @NathanShockCtrs ! Featuring four keynote speakers: Profs @mariabrbic, Anne Brunet, Vadim Gladyshev, @james_y_zou. Check it out! sites.google.com/cs.washington.…

So proud of @AngelinaHolcom for winning a poster prize for her work on metabolic regulation of neurogenesis at the Bay Area Aging Meeting! 😎 @BuckInstitute

Incredibly excited to share our paper on the impact of partial reprogramming on neurogenic niches of the old brain (in mice)!! Massive congratulations to first-author Lucy Xu and all the authors!! 🌟🙌🍾 nature.com/articles/s4358…