Brunet Lab

Our new Comment is out today in @natrevbioeng. mRNA could treat many more diseases than it currently does, but we don’t have a way to get it to most of the cells where it’s needed. We explain why a cell will be the next transformative delivery vehicle⬇️

PerturbFate is officially out in @Nature today! From chromatin to RNA, we dissect the causal regulatory logic linking genotype to phenotype. Huge thanks to my PhD advisor @junyue_cao @Wei_Zhou_1989, and @RockefellerUniv for providing such an incredible research home!

I am thrilled to say that I have accepted a position as Assistant Prof at @Stanford CV Medicine and am launching the Weldy Lab at Stanford! My work integrates genetics, epigenetics, RNA biology, and cardiovascular disease. Check it out: weldylab.org Recruiting!

in @CellCellPress, using iDISCO+ clearing & spatial transcriptomics, @nicolasrenier lab maps how cerebral vasculature forms across the whole brain. Reveals three phases—growth, specialization, refinement—linking vascular remodeling to neuronal maturation. cell.com/cell/fulltext/…

Fantastic weekend at the @brkthroughprize celebration, finally celebrating our Breakthrough Prize in Life Sciences with @HymanLab. What an incredible event!

This program transformed my career. Give it a shot! @hhmi_science's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, + salary & benefits. Postdoc? This year's comp has a program for you too. Opens 11/3! bit.ly/4vhC0LA

Excited to share my lab’s new paper out today @CellCellPress. "Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity" Congratulations to this amazing team of scientists. cell.com/cell/fulltext/…

The Killifish Collections Project website is a beautifully produced collaborative archive dedicated to collecting, validating, and sharing data on global killifish collections, helping preserve pure populations of killifishes in the hobby and academia. 🔗 killifishcollections.net

3D genome architecture underlies health & disease, but its biochemical basis is hard to study at scale. We present Plate-C: a screening platform that profiles thousands of whole-genome 3D maps in a day ($4 each), discovering many pathways that rewire DNA: biorxiv.org/content/10.648…

✨Registration is open for the 2026 FASEB on Chromatin and Epigenetics in Aging and Disease! ✨Featuring Keynotes @DenaDubal and Yang Shi! Short talks are available and trainees are invited to a pre-meeting event. events.faseb.org/event/Chromati…

We have an exciting new story out at @ScienceMagazine's Science Immunology! It is about using #AAV cytokine delivery to change the lung environment. We can boost #lung #Tregs or delivery anti-inflammatory #cytokines, preventing fatal respiratory collapse science.org/doi/10.1126/sc…

Postdoctoral openings to investigate how (i) experience-dependent actuators of inhibitory circuit plasticity mechanisms & neurogenesis contribute to memory operations (ii) how a novel lipid signaling mechanism mediates cognitive resilience and regulates healthspan. 1/2

Years in the making: a detailed aging gene signature in mice and rats. >30 tissues, high Ns, multi-time points throughout the lifespan. >5000 samples in total. The data is accessible, so you check to see if your favorite gene is age-regulated. science.org/doi/10.1126/sc…

A team funded by the Simons Collaboration on Plasticity and the Aging Brain created a comprehensive atlas of aging in killifish: simonsfoundation.org/2026/03/30/sci… #science #neuroscience

Online now!✨Mining the longitudinal plasma proteome of CALERIE participants, @MishraManish29, @Hee_Hoon_Kim et al link C3a to inflammaging. In aged mice, visceral fat macrophages produce C3a and neutralizing it blocks inflammaging @VishwaDeepDixi1 nature.com/articles/s4358…

So excited that our work on Programmable Macromolecule Delivery via Engineered Trogocytosis is out in @NatureCellBio! Link: rdcu.be/fa90i @stanleyqilab @Stanford_ChEMH @bioe_stanford @StanfordBioX A 🧵on our story:

@BBParis1984 @SimonsFdn Congratulations Bérénice and team!! Fantastic work!! 🤩⭐️🐟

🚨 New preprint alert! 🚨 A study 6 years in the making, made possible by funding from @SimonsFdn: "A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging" up on #biorXiv biorxiv.org/content/10.648… a 🧵 1/11

You can now give your agent deep knowledge of millions of papers in one line with #paperclip!📎 >8 million papers natively indexed for agents. Much more thorough + often 10x faster than standard deep research. Just add the paperclip mcp (instruction below).

Interested in aging and rejuvenation? We have a new Research Assistant position to understand aging at the cellular level!! Come join our team!!! 😎 careersearch.stanford.edu/jobs/life-scie…