Brunet Lab

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Brunet Lab

Brunet Lab

@BrunetLab

Aging lab @Stanford - Epigenomics and metabolism in #aging; Brain aging and rejuvenation; Neural stem cells; C. elegans; African #killifish

Stanford, CA Katılım Mart 2010
4.4K Takip Edilen11.1K Takipçiler
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Aaron Cravens
Aaron Cravens@crav1ngcravens·
Today our team at Revel published a paper we've been working towards for several years: the first enzymatic reversal of an aging hallmark in human tissue. nature.com/articles/s4146…
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Jesse Engreitz
Jesse Engreitz@jengreitz·
An encyclopedia of enhancer-gene regulatory interactions — online today! nature.com/articles/s4158… Now with an improved model, expanded maps across 1400+ biosamples, larger validation CRISPR datasets, and guidance on applying the model 1/
Jesse Engreitz@jengreitz

An encyclopedia of enhancer-gene regulatory interactions in the human genome x.com/argschwind/sta… Very proud—4 years in the making, huge team effort. This is a paper where the author list cannot convey everyone's incredible contributions. My holiday highlights below: 1/

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Andreas Gschwind
Andreas Gschwind@argschwind·
Our paper is now out in Nature! 🎉 Expanded to 92M+ enhancer–gene links across 1,458 biosamples, with new benchmarks and analyses. "An encyclopedia of human enhancer–gene regulatory interactions": nature.com/articles/s4158… Grateful to the whole team of this massive effort!
Andreas Gschwind@argschwind

Excited to share our latest work on bioRxiv! biorxiv.org/content/10.110… A highly collaborative effort with @ksmualim @karbalayghareh, @mayayayas, @kanishkadey, @evelynjagoda,@WangXijhu, @LarsMSteinmetz, @anshulkundaje, @jengreitz and many others from @ENCODE_NIH! Thread👇

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Anne Churchland
Anne Churchland@anne_churchland·
Exciting work from my @dgsomucla colleague @BhaduriLab. Understanding how the brain develops is turning out to be key to understanding how brain tumors hijack those same programs. The boundaries between neuroscience & cancer biology are dissolving in the most productive way. 🧠
UCLA Neuroscience Theme@UCLANeuroTheme

Glioblastoma is one of the most devastating brain tumors we know of, & one reason it is so hard to treat is that it doesn't play by normal rules. A new review from Aparna Bhaduri's lab at @dgsomucla reveals why: GBM tumor cells behave like cells from a developing brain, proliferating & differentiating , but w/o the normal controls. By studying the progenitor cells that build the human cortex, Bhaduri's lab is finding unexpected parallels that could point toward new therapeutic strategies. Understanding the brain to fight brain cancer. This is what neuroscience at the intersection of cancer biology looks like. 🧠 annualreviews.org/content/journa…

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Param Priya Singh
Param Priya Singh@param_p_singh·
We are continuing to expand Killiverse with new datasets and features, and we hope it will become a useful resource for the killifish, aging, and broader comparative biology communities. Website: killiverse.org Preprint: biorxiv.org/cgi/content/sh…
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Param Priya Singh
Param Priya Singh@param_p_singh·
Killiverse was built to address this challenge. It provides an interactive, browser-based platform that aggregates datasets across studies, tissues, life stages, species, and experimental conditions in a single resource.
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Param Priya Singh
Param Priya Singh@param_p_singh·
Killifish are a prime example. They have become important models for aging, regeneration, developmental biology, stress resistance, and more. Yet the growing collection of multi-omics and single-cell datasets remains fragmented and challenging to navigate.
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Param Priya Singh
Param Priya Singh@param_p_singh·
Excited to share Killiverse, a new resource that brings together multi-omics datasets across killifish species and life stages, with a focus on aging and diapause biology. 🔗 killiverse.org 📄 Preprint: biorxiv.org/cgi/content/sh…
Param Priya Singh tweet media
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Syd Sattler
Syd Sattler@sydsat·
What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. biorxiv.org/content/10.648… Huge thanks to my PI, @Ohnolog! 🧵
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Isha Jain
Isha Jain@ishahjain·
🧵 Check out our new paper in @NatureMetabolism: rdcu.be/fsLXJ! Hypoxia rescues a mitochondrial proteostasis disease, extending our hypoxia therapy program beyond primary Complex I disease. Stay tuned for more July preprints! And we are still hiring stellar postdocs!
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Yun S. Song
Yun S. Song@yun_s_song·
I am thrilled to share that UC Berkeley and UCSF have launched a joint initiative in Computational Biomedicine! cdss.berkeley.edu/news/uc-berkel… We will soon be recruiting new faculty and postdoctoral fellows. Please repost to help spread the word.
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Hongjie Li
Hongjie Li@HongjieLi5·
Our new preprint, why does Rapamycin increase female lifespan more than male? Building Rapamycin fly cell atlas, we revealed a new aging state, called Convergent Aging Trajectory (CAT). It helps understand why aging and rapa impact male/female differently. share.google/3Xsbch5ThsqLeA…
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Phil Abitua 🧬
Phil Abitua 🧬@Ohnolog·
Annual killifish make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil
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Papagiannakopoulos Lab
Papagiannakopoulos Lab@ThalesPapaG·
Excited to share our new paper in @ScienceMagazine A subset of lung cancers drives cachexia, not through factors circulating in the blood, but through local lung sensory neurons. science.org/doi/10.1126/sc… big thanks to first authors Michael and @s_kotschi our collaborators
Cancer Grand Challenges@CancerGrand

What if one of cancer’s most devastating side effects could be reversed? Cancer cachexia is a debilitating wasting syndrome that affects many people with cancer, yet treatment options remain limited. Team CANCAN has published new research in @ScienceMagazine that highlights a previously underappreciated driver of cancer cachexia: localised signals from tumours acting directly on sensory neurons. This is a big step toward reframing cancer cachexia as not only a systemic metabolic condition, but also one shaped by tumour–nerve communication. 🎥 @ThalesPapaG, Co-Investigator on team CANCAN and team InteroCANCEption, explains the discovery and what it could mean for patients. Read the full paper: science.org/doi/10.1126/sc… --- Team CANCAN is funded by @CR_UK and @theNCI through Cancer Grand Challenges.

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Keşfet

@ScienceMagazine @jengreitz @dgsomucla @BhaduriLab @param_p_singh @Ohnolog @RutterLab @ThalesPapaG