David Polefrone

My first-ever (second-author) publication is now online as a preprint! The “isotopomer project” was as fascinating as it was challenging over the last ~3 years, and it’s great to be able to share the full story. Congratulations to the rest of the team! chemrxiv.org/engage/chemrxi…

Happy Boxing Day to the best team in football… just came across this classic: youtube.com/watch?v=vEYh9M…

@molandergroup You’re still affiliated with Penn Chemistry? How?

Very excited and honored to be included in #ClarivateRanking of highly cited researchers - one of only two chemists in Penn Chemistry! Exceedingly grateful to all the great coworkers who made this possible!

@SuperScienceGrl Interested!

Exciting news: just launched a #codingForChemists Discord community! It's aimed at anyone who studied chemistry and now wants to learn coding. Especially total beginners! For questions and general chat Pls reply or DM me (if you can) for an invitation! #ChemistsWhoCode

@gutierrez_lab @ChemBiochemUMD @adse_penn Thanks very much :') y'all really are the "real OGs"

Thrilled to share that I’ve been awarded the NSF Graduate Research Fellowship! To all my teachers, mentors, coworkers, friends, loved ones along the way, thank you. Your support has made, and continues to make, all the difference.

Do you ever think: What probabilistic ML model is best for my small chem dataset? How does it perform in experiments (ie. Bayes opt)? And how well does it generalise to out-of-distribution molecules? Check out DIONYSUS (formerly GPmol)! arxiv.org/abs/2212.01574

1/ Excited to share our new paper "Labor advantages drive the greater productivity of faculty at elite universities" in @ScienceAdvances with @hneutr @danlarremore @aaronclauset: scim.ag/AV Why do faculty publication rates increase so much with prestige? Let’s go:🧵

@Melt_Dem Despite structural similarity, methamphetamine is much more potent than Adderall (let alone differences in formulation). They’re very much not the same thing; conflating them is irresponsible on several levels

blows my mind that 41M adderall prescriptions were dispensed in the US in 2021 41M people casually tweaking on pharmaceutical grade amphetamines every day the re-branding of meth has been one of the greatest marketing campaigns of the decade, truly wild

@MingbinYuan Congrats Mingbin, great stuff!

Congrats to all! Come see our latest work on constructing E/Z-selective chiral a-vinyl phosphonates! I especially like that we investigated the mechanism of how photocatalyst activates vinyl bromide as well as inducing the E/Z selectivity with its triplet state energy.

@sksilverman @DirkTrauner Perhaps interestingly, if we were concerned with the ordering of strokes, the same expression/number would work for the possible outcomes when using 6 length-1 strokes

@DirkTrauner 6! × 2⁶ = 720 × 64 = 46,080 ways (This does inherently account for stroke length)

And here is the science challenge: How many ways are there if you account for all possible starting points (1-6), stroke lengths (1-6 segments), and directions?

It was great meeting national ADSE board member Professor Steven Lopez today! @StevenLopez_neu @DirkTrauner @KozlowskiMarisa @PennChemistry @ADSE_national

pubs.acs.org/doi/10.1021/ac… Super excited to share the first project of my PhD published now in @JOC_OL. Many thanks to @b_orzy and the rest of the @KozlowskiMarisa group.

Looks like Shohei Ohtani is ready to see @Lj_era8 suit up this weekend 👀 📸 @Angels

From Jacqueline M. Cole @Cambridge_Uni: The chemistry of errors nature.com/articles/s4155…

A somewhat autobiographical perspective on programming, data, and organic chemistry, in @ChemistryWorld. And a hint that soon, I will be starting a new job. 😊 chemistryworld.com/opinion/integr…

Why do so many experimental chemists distrust computations? And what can we do to fix this? (spoilers: have higher standards, standardize our protocols, and accept the limits of our methods) corinwagen.github.io/public/blog/20…

Bond by bond Molecular editing of C3-C7 was daunting, to reverse the order looked impossible as we call this Apollo 17 moonshot. In addition to distance and geometry, we used chiral recognition to realize this feat for the first time, @nature