Dr Ben Evans
805 posts

Dr Ben Evans
@drbennye
Research Fellow @NBS_NTU // PhD in Work Psychology




Trump imposes tariffs on European countries (Denmark, Norway, Sweden, France, Germany, The United Kingdom, The Netherlands, and Finland) over Greenland. This is getting ridiculous!





How many of us routinely assess fatigue in our IBD patients? 🤔 🧪 Results (VIVID-1 Trial, JCC 2025): Mirikizumab led to significant fatigue improvement vs placebo in Crohn’s disease. By Week 52: 46% achieved ≥6-point and 36% achieved ≥9-point improvement (vs 20% & 16% on placebo). Fatigue correlated strongly with quality of life and depressive symptoms, but only weakly with biomarkers and endoscopy. 💡 Clinical Implications: Fatigue is a meaningful therapeutic outcome, not just a secondary symptom. Improvement reflects patient well-being, highlighting the need for multidisciplinary care (GI + mental health). PROs (patient-reported outcomes) should complement clinical and endoscopic endpoints. ⚠️ Limitations: Self-reported fatigue (recall bias, overlap with QoL measures). Limited diversity (mostly White/Asian patients). Psychological and lifestyle factors (sleep, anxiety, non-pharmacologic care) not fully controlled. 👉 Should fatigue improvement become a treatment target in IBD alongside remission? Impact of mirikizumab treatment on fatigue in patients with moderately to severely active Crohn’s disease: results from the phase 3 VIVID-1 study academic.oup.com/ecco-jcc/artic…























