David O'Connor

Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in @BloodJournal, we’ve discovered an intriguing mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL. Thread👇

'Whole genome sequencing is special because we can look at the entire genome instead of parts of a genome.' Genome expert @AngusHodder says 'if we know a child has a less risky form of cancer, we can give them less intensive treatment' #SJUK trib.al/1DqoA75 📺 Sky 501

'Whole genome sequencing is special because we can look at the entire genome instead of parts of a genome.' Genome expert @AngusHodder says 'if we know a child has a less risky form of cancer, we can give them less intensive treatment' #SJUK trib.al/1DqoA75 📺 Sky 501

Following the success of @CRUKresearch’s Clinical Academic Training Programme over the past 5 years, this is an important further investment in the next generation of clinician scientists across Scotland and England. Clinician scientists play an essential role in bridging the gap between discovery research and clinical research involving patients, and this funding will help accelerate the development of cancer treatments in the future. news.cancerresearchuk.org/2024/04/05/58-…

Just out in @BloodJournal – our study exploring the origin of late relapses in T-ALL. Here's a short thread with our unexpected results! ashpublications.org/blood/article-…