Victor Llombart retweetledi
Victor Llombart
39 posts

Victor Llombart retweetledi

Anyone else having issues with tiny holes in the bottom of @VWR tubes? This happened to me twice this week, luckily not with anything precious or radioactive (although having it happen with phenol:CHCl3 is not great!)!
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Victor Llombart retweetledi
Victor Llombart retweetledi

We are thrilled to announce that we finally have the approval for our Phase 1b study to test OMO-103 in metastatic PDAC patients in combination with standard of care in first line! This is another milestone for @peptomyc and its fantastic team. Stay tuned.

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Victor Llombart retweetledi
Victor Llombart retweetledi

Disadvantages for non-native English speakers in scientific research.
*propose a ‘concerted effort, at institutional level, to minimise the disadvantages for non-native English speakers’
* survivorship bias explains disappearing disadvantages
journals.plos.org/plosbiology/ar…

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Victor Llombart retweetledi

Late to the party, just to say that this is changing biology as we know it.
Protein complex prediction with AlphaFold-Multimer biorxiv.org/content/10.110…
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Victor Llombart retweetledi

Our chemogenetic tool SPARK-ON decouples phase separation from protein levels, drives condensate formation including transcription factors and cytosolic proteins e.g. G3BP1, enables dissection of the biological role of phase separation. Thanks @ACSCentSci. pubs.acs.org/doi/10.1021/ac…
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Victor Llombart retweetledi

Targeting Biomolecular Condensation and Protein Aggregation against Cancer | Chemical Reviews pubs.acs.org/doi/10.1021/ac…
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Victor Llombart retweetledi

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec.
We explore 4 intracellular and intercellular applications of TransitID:
- discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix)
- mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress
- discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery
- analysis of proteins that traffic intercellularly bw tumor cells & macrophages
Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor
authors.elsevier.com/a/1hKLcL7PXmcqA

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Victor Llombart retweetledi

Need to drug an intrinsically disordered protein (#IDP)? Why not try 19F #NMR transverse spin-relaxation? Check out our most recent work, now on @biorxivpreprint. @DFlemmingHansen @bhu_vaibhav @FigueiredoAm #NMRchat 🍝 💊 🧲
A 🧵👇🏽: (1/14)
biorxiv.org/content/10.110…
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Victor Llombart retweetledi

👏 We are excited to introduce you to our new John Goldman Fellow for 2022 @Richardson_S_E, from @Cambridge_Uni.
Find out more: leukaemiauk.org.uk/in-pursuit-of-…
🧵...
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Victor Llombart retweetledi
Victor Llombart retweetledi
Victor Llombart retweetledi

The coronavirus has had a devastating impact on our finances. As a result, today we presented a proposal to our staff that would mean us becoming smaller. It’s a sad day for everyone connected with our charity. 💔
Read our statement 👇
bloodcancer.org.uk/news/blood-can…
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Victor Llombart retweetledi
Victor Llombart retweetledi

As promised, here is the updated figure with data from yesterday. You can see how the UK epidemic is closely following Italy's, with a 14-15 day lag and the same doubling rate. We need a national lockdown by Monday just to be as badly hit as Italy. Time is running out.#UKlockdown

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Victor Llombart retweetledi
Victor Llombart retweetledi










