Waleed Hussein وليد حسين

1/5 Although it was published a couple of weeks ago, let me highlight some of the main findings from our latest paper on the burden of Mendelian diseases in the first release of data from the #QatarGenome Program. genomemedicine.biomedcentral.com/articles/10.11…

@AdrianoAguzzi High-throughput sequencing or sometimes second-generation sequencing are better options

@JFGariepy @elonmusk Do you even know/understand what does this plot mean? I doubt that For those who don’t know, PCA by definition focuses on genetic variations that are shared which represent a tiny fraction of the total DNA sequence, approx. 1 or 2%. You shared 50% of your DNA with your child.

Most people don't realize that interbreeding with other races means that strangers on the street from your own race are more related to you than your own child. Amplify this, @elonmusk and spread the knowledge!

5/5 For cumulative gene carrier frequency, we find considerable variation between the Qatari subpopulations, and some of these high-burden genes match diseases of the tier-3 list of ACMG secondary finding genes or those of the newborn screening program in Qatar.

4/5 The gap of non-European ancestries in genomics is shown in the discrepancy of AF between the Qataris and public databases. Many common alleles (AF >3%) are either: - Founder alleles with pathogenic effects - Common variants with no effect, these are P/LP variants in ClinVar

1/5 Although it was published a couple of weeks ago, let me highlight some of the main findings from our latest paper on the burden of Mendelian diseases in the first release of data from the #QatarGenome Program. genomemedicine.biomedcentral.com/articles/10.11…

Tandem repeat @GenomeInABottle benchmark @NatureBiotech out today: rdcu.be/dFQNN . Characterization of 1.7 million TR + benchmark variants + new method to overcome var. representation issues! Great work lead by Adam E. @BCM_HGSC & great collab. from so many! (1/4)

Our study on rare genetic diseases in a diverse Middle Eastern cohort from Qatar has been published in the prestigious Genome Medicine journal. The study analyzed over 6,000 whole genomes and corresponding health data from Qatar. It provides key insights into the distribution of risk for genetic diseases, which will help with public health planning for the country's population and the wider region. Click here for more on the study: bit.ly/3Jz7s1k Full text of the study: bit.ly/4brzVlN @kfakhro | @QatarGenome | @Qatar_Biobank | @HMC_Qatar

نُشرت دراسة أجراها سدرة للطب حول الأمراض الوراثية النادرة لدى مجموعة واسعة ومتنوعة من سكان الشرق الأوسط بدولة قطر، في مجلة جينوم ميديسين المرموقة. تقدم الدراسة، التي تحمل عنوان "عبء الأمراض المندلية في بنك حيوي شرق أوسطي"، رؤىً مهمة حول توزيع مخاطر الأمراض الوراثية في دولة قطر، الأمر الذي سيساعد في تخطيط الصحة العامة لسكان البلاد وسكان المنطقة ككل. حللت الدراسة أكثر من ٦٠٠٠ جينوم كامل وبيانات صحية ذات صلة من دولة قطر. اضغط هنا لمزيد من المعلومات حول الدراسة: bit.ly/3xQIBn6 الدراسة كاملة: bit.ly/4brzVlN @kfakhro | @younesmokrab | @QatarGenome | @Qatar_Biobank | @HMC_Qatar

Burden of Mendelian disorders in a large Middle Eastern biobank @annnlynch genomemedicine.biomedcentral.com/articles/10.11…

Read the paper out now in Genome Medicine here: genomemedicine.biomedcentral.com/articles/10.11…

New research by @younesmokrab, @kfahro and colleagues @SidraMedicine provides novel insights into the burden of Mendelian Disorders in the Qatar Genome Program cohort. This study underlines the need for investigations into biobanks from globally under-represented ancestries.

@ItaiYanai @NeilShubin It is Interesting how believes with some can be labeled as science.

1. How did our limbs evolve? It was predicted that rocks of age ~380 million years would have fossils of fish coming on land. And there they were! Skeletons were discovered with half-fish, half-tetrapod limb bones & joints, w/ a functional wrist joint & radiating, fish-like fins.

What's the evidence for Evolution? If you want to give Creationists something to think about, here's my top 10 list of classic discoveries from genomics, biogeography, the fossil record, microbiology, developmental biology, origin of life work and population genetics. 🧵🔽 (1/11)

@HirofumiNakaoka Good luck! Unfortunately I won’t be there this year.

I will present our recent work entitled "Clonal selection and diversification of somatic mutations in normal human endometrial epithelium" at #ASHG2023. Session 057 - Comparative omics to explore tumor landscapes begins on Nov 3, 2023 at 10:45 AM.

@Byoussef Just wondering how much are you gonna be paid?

@POTUS See who is taking about dictators not paying the price.

History has taught us that when terrorists don’t pay the price for their terror or when dictators don’t pay a price for their aggression, they cause more chaos, death, and destruction. And the costs and threats to America and to the world keep rising. We must not walk away.

@anshulkundaje I am not sure if you know Arabic or you are accepting information because it is coming to you from a reliable source as you think. What is being said here doesn’t prove anything as they said is “They are talking it is from our side”. The reference to the word “They” is not clear.

x.com/IDFSpokesperso… Here are two dumbfk terrorists scratching their dumbfk heads about how they fk up so bad 2/2

It is becoming amply clear the Gaza hospital explosion had absolutely nothing to do with IDF & entirely due to dumbfk terrorists shooting failed rockets into their own backyard. Maybe we shud all wait before reinforcing our priors, cuz misinfo can result in further escalation. 1/

@KhalidJamal149 الدراسة بها عدة اشكاليات، ابتداءا من تعريف السلوك الجنسي المثلى الذى تضمن نسبة كبيرة (حوالى ٦٠٪) من السلوك العارض، قد يكون غير مقصود، الى جودة المصادر الاولية التى اعتمدت عليها الدراسة. لا شك لدى أن مثل هذه الدراسات يتم التساهل معها فى عملية النشر لأسباب ايديولوجية.

@Nilofer_tweets @SaveToBookmarks

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