Dr.Vimoj J. Nair MBBS MD MSc FRCPC

Did you get your poster accepted for @caro_acro_ca Annual meeting? Don't forget to upload your poster at the CARO-Cureus Channel . cureus.com/channels/5/mee… @caroresidents See your email from CARO for details! @mary_hooey

Colonoscopy vs FIT vs no screening 🩺 What do we actually gain in the first 5 years? 🧠 SCREESCO RCT (Nature Medicine 2026) finally includes a true usual-care control arm 📊 👥 278k screening-naive adults 🎂 Age 60 years ⏱️ Median follow-up 4.8 years 🧪 Arms 🔵 Once-only colonoscopy 🟢 FIT ×2 (two-stool, low cutoff) ⚪ No screening 📊 Key results ❌ Overall CRC incidence: no reduction ⬆️ Stage I–II CRC • Colonoscopy IRR 1.38 • FIT IRR 1.19 ⬇️ Stage III–IV CRC • Colonoscopy IRR 0.86 • FIT IRR 0.71 ⚠️ Harms 🩸 Slight ↑ GI/CV events in year 1 🧬 Serious colonoscopy AEs ~0.2% ⚖️ No excess all-cause mortality 🧠 Clinical takeaway Screening delivers an early stage shift, not early incidence reduction 🎯 Mortality data still awaited ⏳ 📖 Full paper in comment ⬇️ #OncoTwitter #GIOncology #ColorectalCancer @esmo_open @OncoAlert @ASCO

Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation A Randomized Clinical Trial jamanetwork.com/journals/jama/…

Can we safely omit radiation in selected locally advanced rectal cancer? The CONVERT trial randomized mesorectal fascia–negative patients to neoadjuvant CAPOX vs ChTR 3-year local control: 96.3% vs 97.4%. Non-inferiority was not formally met ⚠️ DFS/OS were similar between arms. Long-term toxicity favored ChT alone. Careful selection may allow de-escalation w/o compromising outcomes. ascopubs.org/doi/pdf/10.120… @JCO_ASCO @OncoAlert

Multinodular & vacuolating neuronal tumor (MVNT) is a rare, benign entity often found incidentally, w/ characteristic MR findings: Subcortical, FLAIR-hyperintense, nonenhancing nodules. In our cohort, most did well w/ conservative management. @JordinaRT_md doi.org/10.1007/s11060…

New research shows that smarter brains burn less glucose to solve the same problems—fewer neurons firing, faster adaptation, cleaner circuitry. In simple terms: higher intelligence = lower energy cost. Another reason to put the phone down and let your brain do its thing. 😉

🆕Online today: Neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy in resectable #pancreaticpancer (PREOPANC-2): a multicentre, open-label, phase 3 randomised trial @BasGrootKoerkam, @MarcBesselink, Dutch Pancreatic Cancer Group thelancet.com/journals/lanon…

🆕Comment: A deliverable national cancer control plan for the UK: lessons from abroad and the need for discipline at home Authors: @QUBCancerProf, @DrCaryAdams, Eduardo Pisani, @YannickRomero, @sar_quinlan, & @prof_price thelancet.com/journals/lanon…

🆕 @NatureMedicine: end-of-life cancer biology. As patients near death, tumors infiltrate major vessels and release surges of CTC/clusters (across multiple solid tumors…) nature.com/articles/s4159… 📌 Vascular invasion strongly associates with mortality, even without overt M1 When cancer takes the “highways” at the end…maybe it’s time we rethink the map itself 🛣️ @OncoAlert #OncoAlertAF @OncoReporte @myESMO @_SEOM @realbowtiedoc @Nature @SuyogCancer

The more exercise in mid- and late-life, the less Alzheimer's and all-cause dementia, adjusted for all known risk factors jamanetwork.com/journals/jaman…

New in JAMA Oncology: Over 231,000 adults followed for 32 years. 🏃‍♂️Consistent mod physical activity (~17 MET-hrs/week = ~5 hrs brisk walking or ~2 hrs running) led to major reductions in digestive system cancer risk. 🔥 More exercise (~39 MET-hrs/week) didn’t bring extra benefit.

Back at #WFNOS2025 #SNO2025 #Hawaii #aloha Excited about the scientific program and seeing all my wonderful colleagues! If you are here do give a shout! soc-neuro-onc.org/SNO2025/SNO202…

New review - Age-related changes of the gastrointestinal tract thelancet.com/journals/langa… #GITwitter #MedTwitter

🧠 Brain care needs ~10 hrs/day — 7h sleep, 1h exercise, 1h meals, 1h social time. But macro → micro factors (work, culture, policy) decide who gets that time. Time poverty = brain poverty. #BrainHealth #Sleep #Wellbeing

Radiation lymphoma studies that are published in rad onc journals are better cited, despite lower impact factor. Lymphoma studies reporting on radiation negative clinical outcomes are more likely to be published in non-rad onc and higher impact factor journals, and by non-rad onc authors: tinyurl.com/rjsaifi

Reirradiation (reRT) is reshaping cancer care—offering hope for recurrent tumors w/ advanced precision techniques like IMRT & SBRT. Multidisciplinary care, imaging, and innovation are key. #OpenAccess review by Andratschke et al: acsjournals.onlinelibrary.wiley.com/doi/full/10.33… @OncoAlert #RadOnc

RadOncReview ftw again. Thank you @jryckman3 🙏. Incredible resource. GI highlights below. #ASTRO25

This was a great talk by Jim Apisarnthanarax on response assessment for liver tumors. Summary slide here on imaging characteristics at diagnosis & post RT for HCC vs. cholangio vs. liver mets is 💯. #ASTRO25

@RadOncTMC @VedangMurthy @ASTRO_org congratulation! @VedangMurthy

@RadOncTMC's own @VedangMurthy is the @ASTRO_org International Ambassador from India 🇮🇳 A proud moment for our community and a well-deserved recognition of his contributions to global radiation oncology.

@OttawaHospital @CHEOhospital @uOttawaResearch @uOttawaRad @RadiationOttawa

@OttawaHospital @CHEOhospital ohfoundation.ca/be-inspired/a-…

Grateful to be part of a team working to improve care for children with cancer. From precision radiation to long-term follow-up, our work at @OttawaHospital & @CHEOhospital focuses on safer treatments and better outcomes. #PediatricOncology #CancerCare #OHRI #TOHF