Omer Dushek

Antibodies are bivalent molecules but we study/optimise them based on their monovalent binding. New work provides a simple method to analyse & predict bivalent binding! The molecular reach of antibodies determines their SARS-CoV-2 neutralisation potency biorxiv.org/content/10.110…

The Sim lab has been hard at work and we’re proud to present our first paper. We developed new methods to study peptide:KIR interactions. Congratulations to star postdoc Tanusya Murali who led the project. biorxiv.org/content/10.648…

To improve TCR-T cell specificity without altering the TCR, Cabezas-Caballero et al. explored the impact of TCR co-receptors on ligand discrimination. CD8 KO in NY-ESO-1 or MAGE-A3 TCR-T cells maintained responses against target peptides and reduced cross-reactivity. With an MHC-I-directed TCR, CD4+ T cells had improved ligand discrimination compared to CD8+ T cells, and CD4 knock-in had similar effects to CD8 KO. Dual CD8 KO + CD4 KI further reduced cytotoxic T cell reactivity against random peptides, single amino acid variants of a target peptide, or predicted cross-reactive peptides, without reducing on-target responses. bit.ly/49Opppg  @j__cabezas  @UniofOxford @Dushek

Review article with Omer Dushek @Dushek on tethered signaling proteins, out now! Tethered bio-molecular reactions can do at least 7 cool things that freely-diffusing reactions do not. Read more here! #IDR #TCells #cytoskeleton annualreviews.org/content/journa…

The @Dushek lab demonstrated that super selective T cells with reduced cross-reactivity and enhanced ligand discrimination can be generated without impacting on-target potency and importantly, without modifying the TCR. 📍 @natBME 🔗 go.nature.com/4jALBYE

Thank you to @embojournal for a constructive and efficient review process.

With a News & Views by Pierre Bongrand and Philippe Robert Unraveling T-cell decoding strategy: a step forward lnkd.in/e2nzjwUR

Our work accurately measuring the 3D affinity between the OT-I TCR and a large number of foreign and self antigen ligands is now published at EMBO Journal. Murine T-cell receptor OT-I exhibits imperfect discrimination between foreign and self-antigens lnkd.in/eYkvifBM

Temporal control of cytokine production is lost in 2nd-gen CAR-T cells, says Patel et al. This could be key to understanding their efficacy and toxicity in cancer immunotherapy. 🧬 🔗 bit.ly/4lOLicw #CancerImmunotherapy

Thanks to our funding, collaborators, constructive reviewers, and for the very efficient process at @ImmunolCellBiol

By comparing the advantages and limitations of each platform, we provide a framework to choose the most suitable system to study signal integration in both basic and translational contexts.

Our new review article led by Jordan Kramer: Platforms for studying cell–cell recognition by immune cells onlinelibrary.wiley.com/doi/10.1111/im…

📢Registration is open for the Biomembrane Days 2025! 🔗biomembrane-days-2025.mpikg.mpg.de A top-notch lineup of speakers, 120 posters, 200 scientists 📜Submit an abstract by July 14 🏆3 Poster prizes ⚠️Limited spots - previous events were fully booked! #BiomembraneDays2025 #CellMembranes

Two weeks to go for our London Quantitative Immunology day on April 10th! Last chance to submit abstracts for contributed talks is today 👉 qimmuno.com/ldnday/

Less than a week left to submit abstracts for the 3rd London Quantitative Immunology Day! qimmuno.com/ldnday/. Register and share your work with a diverse set of biologists, physicists, mathematicians all united by a common interest in immunology. @UDemael