Andreas Tiffeau-Mayer

The Sim lab has been hard at work and we’re proud to present our first paper. We developed new methods to study peptide:KIR interactions. Congratulations to star postdoc Tanusya Murali who led the project. biorxiv.org/content/10.648…

More broadly, these findings might also help inform emerging protein design approaches to reduce unwanted immunogenicity

An important implication for cancer treatment is that neoantigens that are just one mutation from self are not strange antigen at all, as sometimes thought.

How different are self and nonself? This is a central question in immunology. In our latest work just published in @PRX_Life we demonstrate that at the peptide-level statistical differences between host and pathogen proteomes are minor

Watch out for future work in which we ask: how much spatial variability in the immune repertoire can be explained by localised clonal expansions?

Our work on these questions has been motivated by our experimental findings uncovering substantial variation in the human immune repertoire across blood and tonsils. doi.org/10.1016/j.immu…

Excited to share the latest preprint from the lab "Fluctuating environments are sufficient to drive substantial variability in species abundance across locations" now up on arXiv arxiv.org/abs/2603.02403 🎉

Looking forward to connecting with many of you!

Later on I will give an invited talk in the session "AI driven insights into immune responses: vaccines, infections, and disease" laying out a vision for combining AI with TCRseq to study human immunity

If you're at @britsocimm Congress, come catch three talks today with updates about our research!

We are #absolutely #thrilled to #present @ImmunityCP - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity cell.com/immunity/fullt…

Excited for the line-up of speakers at the London Quantitative Immunology Network meeting Nov 19th -- check out the programme here 👉evilab.ai/quantitative-i… Come join us at ICR Chelsea :)