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Really pleased to see this Opinion Review out.
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology
cell.com/trends/immunol…
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Malcolm Sim
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Malcolm Sim
@mjwsim
MRC Career Development Fellow - group leader @UniofOxford. Medical Research Fellow @CorpusOxford. Also on https://t.co/voX9Vygwwz opinions my own
England, United Kingdom Katılım Ekim 2014
4.7K Takip Edilen1.8K Takipçiler
Malcolm Sim retweetledi
Ultra-high-throughput IGH genotyping of 25 global populations reveals population-biased allelic diversity and homozygous V and D gene deletions @ImmunityCP
cell.com/immunity/fullt… @NillaKH @karolinskainst
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Malcolm Sim retweetledi
Unpaired TCRα + TCRβ sequencing is sufficient for training machine learning TCR-epitope recognition predictors biorxiv.org/content/10.648… #biorxiv_immuno
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Malcolm Sim retweetledi
I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo.
A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models.
#Ack1" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…
a 🧵
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Malcolm Sim retweetledi
academic conferences are crazy because it’s like Let’s go to the most beautiful place in the world and then look at powerpoints for 12 straight hours
Notre-Dame-des-Anges, Québec 🇨🇦 English
Malcolm Sim retweetledi
A high-affinity nanobody that disrupts the CLEC12B–lipoprotein lipase axis, thereby revitalizing NK cell activity and suppressing tumor progression in preclinical models @NatImmunol 🇨🇳
nature.com/articles/s4159…
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Malcolm Sim retweetledi
Preprint: Vaccination rescues dysfunctional T cell therapy by amplifying rare stem-like antitumor CD8⁺ T cells researchsquare.com/article/rs-894… @NCICancerCtrl
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Malcolm Sim retweetledi
@MalmbergLab commentary on the recent Carrington Lab paper
A genetic set-point for natural killer cells
nature.com/articles/s4159…
@NatImmunol
nature.com/articles/s4159…
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Malcolm Sim retweetledi
@biorxivpreprint CXCR4 coordinates adhesion, migration, and development of human NK cells
biorxiv.org/content/10.648… @ShiraEisman @Columbia @mace_em
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So many AI tech bros in my feed think someone Australian guy just invented neoantigen vaccines to shrink 1 (one) canine tumour.
Malcolm Sim@mjwsim
Lots of people saying ‘why can’t we do this humans?’ We are doing this in humans… Why do you think all this tech already exists!
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Lots of people saying ‘why can’t we do this humans?’
We are doing this in humans…
Why do you think all this tech already exists!
Patrick Heizer@PatrickHeizer
Sorry to be the downer because this is an impressive story in some senses. But it is ~trivially easy to make a single mRNA vaccine. It's not hard. I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year. What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade. I am happy for this man and his dog. It is impressive. But y'all are overhyping it.
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The Sim lab has been hard at work and we’re proud to present our first paper.
We developed new methods to study peptide:KIR interactions.
Congratulations to star postdoc Tanusya Murali who led the project.
biorxiv.org/content/10.648…
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I was at a conference in Texas last week and tried to pay for a drink at the hotel bar with contactless (Apple Pay).
They didn’t take it. In 2026.
Canadian Monarchy Respecter 🇨🇦👑🍁🇻🇦@CdnMnrchyRspctr
Today found out the Yanks do not have e-transfer and they have to pay to use shitty apps to move money around
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Malcolm Sim retweetledi
Malcolm Sim retweetledi
🧵 🚨 Our new paper is out today in @FrontiersIn #Ecology and #Evolution. 🎉 🥳 🙌
For decades, many textbooks & papers have claimed that group or multilevel selection lacks empirical evidence.
We decided to test that claim.
Here’s what we found 👇
doi.org/10.3389/fevo.2…
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