Malcolm Sim

Really pleased to see this Opinion Review out. The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases: Trends in Immunology cell.com/trends/immunol…

‘Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I’ Our first publication, a method we’ve been working on, and a big milestone for the Sim lab! academic.oup.com/discovimmunolo…

OUT TODAY IN PAPERBACK IMMUNE HEALTH: A Myth-busting Guide. ‘Will change how you think about your body and live your life’ @DoctorChrisVT ‘Brilliant’ @LizEarleMe 'Beautifully written overview' @ProfBrianCox 'Best book on immune health I have ever read' @theAliceRoberts

Antibody S22019F Selectively Recognises KIR2DS1 and Enables Analysis of KIR2DS1+ NK Cells and T Cells @QuirinHammer @karolinskainst onlinelibrary.wiley.com/doi/10.1111/ta…

A highly efficient nonviral knock-in platform for NK cells, enabling plasmid-based genome editing with up to ∼90% knock-in efficiency and ∼100% recovery rupress.org/jem/article-ab… @JExpMed #Felices #Miller @UMNews

@biorxivpreprint Early-life mucosal T cells direct intestinal stem cell fate via a coordinated developmental program @LizaKonnikova @Yale @madisonstrine doi.org/10.64898/2026.…

Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery go.nature.com/3QWMRet

Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution @NatureComms @LabHeath @UW nature.com/articles/s4146…

Congrats to Julia, Ricardo and the team for this great work. Exciting to see it out in the world!

Well, again -for the lovers of #TCRs and #crossreactivity #Reverse #engineering the fatally #crossreactive #A3A #TCR to decouple potency and #specificity @theRafLab @CAMS_COI_Ox biorxiv.org/content/10.648…

I had the pleased hosting the KIR work in Oxford this week. An amazing experience full of great science with new and old friends and colleagues.

@LocasaleLab My wife was on this trial. Stage 4 panc cancer, 40 years old. She was in this trial and lived 18 months after chemo stopped working. We took trips to Spain, Disney, Jersey Shore. She got two more birthdays with our kids. Shove your hype and misrepresentation up your ass.

Purification of HLA-G+ Extravillous Trophoblasts from Human Term Placental Tissues for Phenotyping and Functional Analysis @TTilburgs @CincyResearch app.jove.com/t/69545/purifi…

Mapping the maternal–fetal interface through pregnancy in high resolution @Nature @UCSF nature.com/articles/d4158… nature.com/articles/s4158…

🚨Paper alert🚨 Very excited to share our manuscript, published today in @ImmunityCP, where we describe how ‘Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome’. (1/16) cell.com/immunity/fullt…

Circulating and tissue TCRβs associated with lynch syndrome, a genetic condition linked to DNA mismatch repair efficacy and cancer risk @evilarsan @NatureComms @MDAndersonNews nature.com/articles/s4146…

Research from @smkrams, @martinezoliviam, Carlos Equsivel, & @KirchnerVaria in @J_Immunol identified a population of NKG2A+ NK cells that can kill Epstein-Barr virus–infected B cells through the NKG2D & NKp30 activating receptors. brnw.ch/21x1dlf

Interested in early life immune development? Come join us. 1. Postdoc: fetal responses to maternal vaccination. 2. Postboc working with @madisonstrine and Brett Vahkal on immune epi cross talk and 3. CC of translational studies konnikovalab.com @YaleMed @YalePediatrics

“Peanut? Yes…that was what they used to call me. Peanut the Grey. That was my name. I am Peanut the White. And I come back to you now, at the turn of the tide.”

@NaOHBartfield I have this shirt.

They had a PD-1 binder shirt at uniqlo Kyoto (??????)

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens. doi.org/10.64898/2026.…