Elizabeth de Guzman

Talk #2 is by @e_deguz (Same session, 13:30 pm). Elizabeth used synthetic (optogenetically-generated) brain oscillations to probe the brain rhythms that *causally* sustain fMRI connectivity Spoiler: Regions of the default-mode network show resonance properties🧠! 2/4

🚨Preprint Alert🚨 I am so happy to share these main results from my PhD. Thank you so much @ZsoltLenkei for the opportunity and the supervision, Andrea Kliewer for this friendship in life and science, @SamuelDiebolt for your trust and unlimited support and all our collaborators

Huge congrats to the incredible @HereCaterina and all coauthors including @e_deguz @MarcoPagani1985 @jockschat, star collaborators @mvlombardo, #yuriBozzi and @LabPasqualetti. And grateful to @SFARIorg and @ERC_Research for funding this work (a looong time ago - 2016!) 4/4

Previous studies have described evolutionarily relevant fMRI networks in mammals 🐁🐒👨 But how can we relate these networks across species? And is their *dynamic organization* also evolutionarily conserved? Here's what @danielgb_87 et al found! ➡️tinyurl.com/t9pwst36 🧵1/n

The official call for a fully-funded PhD scholarship in my lab is now online at @cimec_unitrento Application link 👉 lnkd.in/dEJ4GBjS Application Deadline is May 31 Research topic is "Synaptic modulation of functional connectivity" lnkd.in/d5vg2kMg #PhDposition

fMRI enthusiasts - your @ISMRM workshop needs your abstracts. Please help spread the word and mark the date on your calendar. We look forward to seeing you in Padua! ismrm.org/workshops/2023…

I've been sending tons to emails today asking for awake 🐭 functional 🧲 or 🎙️ datasets. If you haven't gotten your email, get in touch!!! #awakerodent #multicenter

#Autism affect males more than females, but the mechanisms underlying this sex bias remain elusive. Our new preprint (with @mvlombardo) describes one of such mechanisms, and the effect it has on brain function and gene transcriptomics. 👉tinyurl.com/nhasuxmj 🧵1/n

Faculty position alert 📣 Our institute @IITalk welcomes applicants with an outstanding track-record in Computational Neuroscience. We provide support for salary, start-up budget, and annual running costs. Feel free to reach out for informal inquires 👉tinyurl.com/7ztdnkbn

Awake whole-brain functional imaging is the new el dorado in our community (fMRI+fUS). Yet, awake datasets (on average) under perform our best anesthetized protocols. I want to identify the protocols and practices that work!

Task-free fMRI is governed by high-amplitude BOLD coactivations (termed "CAPs"). But how do these patterns emerge and what do they mean? New collaborative work conceived by #Diego_Fasoli and #Stefano_Panzeri provides possible explanations 👉tinyurl.com/2p8un5kp 🧵1/n

How do cortical perturbations affect fMRI connectivity? Not necessarily as one would expect! Our new work @NatureComms shows that cortical inactivation may unexpectedly INCREASE fMRI connectivity! rdcu.be/cHKie 🧵below explains how. Spoiler: δ oscillations are key! 1/n

Excellent commentary by @EvelynMRLake of our recent investigation of fMRI dynamics in conscious mice Commentary➡️Consciousness: Mapping the awake mouse brain (tinyurl.com/hnj8am44) Link to original article➡️tinyurl.com/2p8k83b4 @CurrentBiology

Out today in @CurrentBiology our latest work (tinyurl.com/2p8k83b4) where ➡️we establish robust methods for awake mouse fMRI ➡️reveal an evolutionarily-relevant "fMRI signature of consciousness" in rodents. Many thanks and congrats to @danielgb_87 & lab! Brief summary below🧵

Out today in @NatureComms our 🐁+👨work where we show that in #Autism ➡️(mTOR-related) excess of synapses causes aberrant fronto-striatal activity ➡️ this signature can be decoded in human fMRI scans, defining an identifiable autism subtype @IITalk 1/4 tinyurl.com/265xy8ha

fMRI mapping has revealed distinctive "signatures of consciousness" in humans🧠and primates🐵 ➡️Can similar patterns of fMRI signal coordination be identified in lower mammalian species? Here is what we found using rsfMRI in *awake* mice🐁🐭➡️bit.ly/38x9FYN Thread 1/n

If you are interested in #fiberphotometry, check out our recent work, led by @MontinaroCinzia in @Ferruccio_PhC & @mdv_67 labs, on how the local brain anatomy shapes the volume you can record from! #neuroscience #optogenetics biorxiv.org/content/10.110… @antoniobalena @marcopis_

#Autism is often associated with an excess of synapses: but how does this trait affect large-scale circuit function? Here's what we found by modelling autism-related pruning deficits across-species🧠🐭 ➡️tinyurl.com/y2yfj74o By @MarcoPagani1985 @mvlombardo & al. Thread 1/n

Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too! Here is what we found using #chemogenetic deconstruction of rsfMRI in the mouse🐁🐭 ➡️Cortical silencing results in paradoxical fMRI overconnectivity tinyurl.com/yy269j92 Thread below 1/n

Join neuroscientist Alessandro Gozzi from the Italian Institute of Technology for the next Feindel virtual seminar entitled "Unravelling brain connectopathy with cross-species #fMRI". Register for free here: eventbrite.ca/e/feindel-virt… #neuroscience