Emma Peterman

32 posts

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Emma Peterman

Emma Peterman

@emmapeterman_

ChemE PhD student @GallowayLabMIT

Cambridge, MA Katılım Ağustos 2020
206 Takip Edilen132 Takipçiler
Emma Peterman retweetledi
Katie Galloway
Katie Galloway@GallowayLabMIT·
Enjoyed the tweetorial? Want to hear more? Come hear @emmapeterman_ live at AIChE this coming Thursday. Details 👇 Thursday, November 6th, 2025 Session #654: Cellular, Protein, & RNA Systems Engineering 8:00 AM, Hynes Convention Center, 310
Katie Galloway tweet media
Katie Galloway@GallowayLabMIT

So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein levels. 🧵

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Katie Galloway
Katie Galloway@GallowayLabMIT·
So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein levels. 🧵
Katie Galloway tweet media
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Katie Galloway
Katie Galloway@GallowayLabMIT·
Today at @CellSystemsCP we report in back-to-back papers (!) led by @nbwang22 on how cell state potentiates the influence of individual transcription factors to drive cell-fate programming & how we used these insights to scale up production of motor neurons from primary fibroblasts, allowing us to deliver these directly converted neurons into the brains of mice. Updated tweetorial coming soon (links below!)
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Prof. Nikolai Slavov
Prof. Nikolai Slavov@slavov_n·
Stronger promoters not only transcribe more RNA but also show higher effective translation rates.
Prof. Nikolai Slavov tweet media
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Emma Peterman
Emma Peterman@emmapeterman_·
Learned so much putting this review together with @DeonPloessl and @GallowayLabMIT 🧬 Stay tuned to hear about how we are approaching these challenges in the lab!
Katie Galloway@GallowayLabMIT

Transgenics have the potential to massively expand the power of cell therapies. However, transgenesis adds a step in the already substantial challenge of scaling up cell-based therapies. How do we ensure that cell therapies can harness the power of synthetic biology? 🧵 (1/n)

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Emma Peterman retweetledi
Katie Galloway
Katie Galloway@GallowayLabMIT·
Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n) Link: doi.org/10.1101/2024.0…
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Katie Galloway
Katie Galloway@GallowayLabMIT·
Or stop by poster #28 to hear from Emma Peterman @emmapeterman_ on her work on "Simultaneous measurement of protein and mRNA levels in single cells for genetic element characterization" in mammalian cells #SEED2024 #synbio @MITChemE
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Katie Galloway
Katie Galloway@GallowayLabMIT·
Excited to say our lab's about to do some "understanding and engineering" with the support of the NSF CAREER Award! Really grateful for fantastic work by my students and support from my department @MITChemE Delighted for the research and outreach this will support. Excelsior!
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Nat B. Wang 🧬🧑🏻‍🔬🏳️‍🌈
Nat B. Wang 🧬🧑🏻‍🔬🏳️‍🌈@nbwang22·
1st preprint is finally out! When I started, as a 🤖 synbio person, there were so many Q's I had on how to build reprogramming vectors 🔧🧬. There's a lot more to do but we show how you encode reprogramming cocktail really matters in TF-specific ways! See tweetorial for more
Katie Galloway@GallowayLabMIT

How do individual transcription factors (TF) influence reprogramming? Isn’t it just the cells with the highest levels of TF expression that reprogram? So just blast them & it should work, right? 🤨Buckle up for our lab’s preprint & tour de force led by Nat Wang @nbwang22 ! (1/n)

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Katie Galloway
Katie Galloway@GallowayLabMIT·
How do individual transcription factors (TF) influence reprogramming? Isn’t it just the cells with the highest levels of TF expression that reprogram? So just blast them & it should work, right? 🤨Buckle up for our lab’s preprint & tour de force led by Nat Wang @nbwang22 ! (1/n)
bioRxiv Cell Biology@biorxiv_cellbio

Proliferation history and transcription factor levels drive direct conversion biorxiv.org/cgi/content/sh… #biorxiv_cellbio

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Nat B. Wang 🧬🧑🏻‍🔬🏳️‍🌈
Nat B. Wang 🧬🧑🏻‍🔬🏳️‍🌈@nbwang22·
If you’re at #ISSCR2023 , come see my poster #285 on Wed, 6pm! Excited to share my work on how we’ve systematically optimized direct iMN reprogramming to explore and improve controllability of reprogramming in both 🐭 mouse and 👤 human!
Katie Galloway@GallowayLabMIT

Wed Jun 14th 6pm: Come to poster #285 and hear Nat Wang tell you about his work on the systems biology-guided design and molecular optimization of circuits for cell fate reprogramming. Nat also won an ISSCR Merit Award for his abstract! (1/n)

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Katie Galloway
Katie Galloway@GallowayLabMIT·
How does transcription of proximal genes influence the expression of their neighbors? How do we engineer compact circuit designs for specific profiles of expression that enable robust cellular engineering? Today @CellReports we provide some answers (1 /n) tinyurl.com/24vtfbyw
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Elisa Granato
Elisa Granato@Prokaryota·
"are you ok?" - no I have to pipette 1008 uL
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Emma Peterman
Emma Peterman@emmapeterman_·
Excited to share my new website! Here's what I've been up to in my first year of grad school and some advice for incoming students. More updates to come! emmapeterman.netlify.app
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Emma Peterman retweetledi
Katie Galloway
Katie Galloway@GallowayLabMIT·
Excited to share our new @biorxivpreprint! Integrating DNA biophysics with classic #synbio to map how to improve transgenic systems by tailoring expression levels, variance, and transcriptional dynamics. TL;DR: Don’t build your systems to fail. Build beautiful dynamics! 🧵(1/n)
bioRxiv Synthetic Biology@bioRxiv_synbio

Supercoiling-mediated feedback rapidly couples and tunes transcription ift.tt/L5NhVKB #biorxiv_synbio

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Keşfet

@nbwang22 @MITChemE @A_BlanchAsensio @kaseyslove @DeonPloessl @GallowayLabMIT @CellReports @aligoldstein_