Emma Peterman
33 posts
@emmapeterman_
ChemE PhD student @GallowayLabMIT
So you want to change transgene expression: just change your promoter, right? Changing the promoter increases RNA and thus protein levels. What more could be happening? [1/n] Well, promoters don’t just set RNA levels; they uniquely transform how RNAs are transmitted into protein levels. 🧵
Loss of gene expression can compromise cellular fitness. In the case of such haploinsufficiency, replacement of the gene supplementation could rescue cell health. But what if you need a very precise dosage? Try ComMAND! 🧵 (1/n) Link: doi.org/10.1101/2024.0…
Transgenics have the potential to massively expand the power of cell therapies. However, transgenesis adds a step in the already substantial challenge of scaling up cell-based therapies. How do we ensure that cell therapies can harness the power of synthetic biology? 🧵 (1/n)
Programmable promoter editing for precise control of transgene expression ift.tt/RchaKp6 #biorxiv_synbio
How do individual transcription factors (TF) influence reprogramming? Isn’t it just the cells with the highest levels of TF expression that reprogram? So just blast them & it should work, right? 🤨Buckle up for our lab’s preprint & tour de force led by Nat Wang @nbwang22 ! (1/n)
Proliferation history and transcription factor levels drive direct conversion biorxiv.org/cgi/content/sh… #biorxiv_cellbio
Wed Jun 14th 6pm: Come to poster #285 and hear Nat Wang tell you about his work on the systems biology-guided design and molecular optimization of circuits for cell fate reprogramming. Nat also won an ISSCR Merit Award for his abstract! (1/n)
