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Anders Sejr Hansen@Anders_S_Hansen·3h

@mazzocca_matteo @DomenicNarducci @SGrosseHolz @_jessematthias @Abberior @hansen_lab @MITdeptofBE (7/7) Thanks also to Tatiana Karpova at NIH for hosting and collab. Huge thanks to @DimitrisTypas @NatureSMB for steering the paper through and improving it: nature.com/articles/s4159… And to Anne Trafton at MIT News for writing a nice overview news.mit.edu/2026/how-chrom…

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Katie Galloway@GallowayLabMIT·2h

@Anders_S_Hansen RCMC! Such a great tool to study folding at high resolution! :)

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Anders Sejr Hansen@Anders_S_Hansen·3h

Detecting plectonemes using RCMC nature.com/articles/s4158…

For contact probability, we used Region Capture Micro-C (RCMC) a methods developed by @Anders_S_Hansen's lab which supports targeted pulldown of a region of interest (figure from Goel, V et al. Nature Genetics. 2023) . Since we are just looking at one locus (CLYBL), we want to spend our sequencing dollars getting high resolution at this locus! And boy did we! ( 23/n)

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Katie Galloway@GallowayLabMIT·2d

@FukayaLab That's very interesting!

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Takashi Fukaya@FukayaLab·2d

New preprint alert! Together with Tetsuya Yamamoto at Hokkaido University, we propose a “polymer micelle” model of transcriptional bursting. biorxiv.org/content/10.648…

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Katie Galloway@GallowayLabMIT·2d

@dhnisz @CSHL @ElphegeNoraLab @MariekeOudelaar @Eileen_Furlong @MiraKassouf @NKrietenstein @leonidmirny @OchsFena looks amazing! CSHL is such a great venue for top-tier science and great conversations!

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Denes Hnisz@dhnisz·2d

Spectacular data, weather and colleagues at #CSHLNucleus #Nucleus2026 @CSHL @ElphegeNoraLab @MariekeOudelaar @Eileen_Furlong @MiraKassouf @NKrietenstein @leonidmirny @OchsFena

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Katie Galloway@GallowayLabMIT·3d

@bloodgenes @lvchosen1 @silvirouskin @Armstrong_dfci @CellPressNews @DanaFarberNews @DanaFarber @BroadMPG @broadinstitute @hhmi_science @BostonChildrens @GauravA_UK @guo_chunjie Congrats, Vijay!

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Vijay Sankaran@bloodgenes·3d

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more! cell.com/cell/fulltext/…

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Katie Galloway@GallowayLabMIT·3d

@hhhcce @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Thanks, Cheen!

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Cheen Euong Ang@hhhcce·3d

@GallowayLabMIT @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Amazing paper with important implications in the field of reprogramming as well. What a tour de force!

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Katie Galloway@GallowayLabMIT·4d

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

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Katie Galloway@GallowayLabMIT·3d

@sahakris Thanks, Kris!

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Krishanu Saha@sahakris·3d

Beautiful work in mammalian synthetic biology!

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

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Nature Biomedical Engineering@natBME

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Katie Galloway@GallowayLabMIT·3d

@ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE couldn't have mapped the mechanism of DNA supercoiling without STRAIGHT-IN Dual now out at Nature BME! x.com/natBME/status/…

STRAIGHT-IN Dual: a platform for dual single-copy integrations of DNA payloads and gene circuits into human induced pluripotent stem cells go.nature.com/4ue2ix4

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Katie Galloway@GallowayLabMIT·3d

@Oli_TN Thanks!

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Oliver Takacsi-Nagy@Oli_TN·3d

Two bangers! (1) it's cool that the authors did mechanism x synbio engineering and (2) the amount of conditions, architectures, etc. included (and shown) is very useful for others even when working in different cell types. Bravo!

So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? Come hear about STRAIGHT-IN Dual now out at Nature Biomedical Engineering! 🧵 Link at end!

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Katie Galloway@GallowayLabMIT·3d

@DavidMTruong Thanks, Dave!

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Dave Truong@DavidMTruong·3d

This is an important paper for those building multi-genic circuits in mammalian cells.

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

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Katie Galloway@GallowayLabMIT·3d

@SongZhimuFeng @lpachter @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE thanks!

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Song Feng 馮松@SongZhimuFeng·3d

@GallowayLabMIT @lpachter @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Amazing work! Congrats.

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Katie Galloway@GallowayLabMIT·3d

@wang_shunzhi @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Thanks!

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Shunzhi Wang@wang_shunzhi·4d

@GallowayLabMIT @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Awesome work, congrats!

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Katie Galloway@GallowayLabMIT·3d

@PZandstra @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @MummeryLab @MITChemE @MITdeptofBE Thanks, Peter! Looking forward to seeing the applications in T cells!

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Peter Zandstra@PZandstra·4d

@GallowayLabMIT @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @MummeryLab @MITChemE @MITdeptofBE Congratulations @GallowayLabMIT ! Happy to be part of the team, led on our side by @jonesr18. This study lays down some of the design principles for synthetic control of cell fate. Stay tuned folks for some interesting applications in T cells.

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Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/…

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Katie Galloway@GallowayLabMIT·3d

@chaserrdad @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE the work CHASERR from @IgorUlitsky inspired us to consider how important transcription of noncoding genes could be in native systems. I hope our work could be helpful in inspiring therapeutics x.com/IgorUlitsky/st…

Igor Ulitsky@IgorUlitsky

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CHASERR lncRNA Dad@chaserrdad·3d

@GallowayLabMIT @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Very excited to learn how this impacts CHASERR. We are now up to 7 cases.

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@emukamel @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE science.org/doi/10.1126/sc…

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Katie Galloway@GallowayLabMIT·3d

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Eran Mukamel@emukamel·3d

@GallowayLabMIT @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Link to the paper?

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Katie Galloway@GallowayLabMIT·3d

@rjerala @ZiboChen @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE lol, my husband asked "at this point, why don't they just read the paper!" but I hope folks enjoy the less formal read :)

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Roman Jerala@rjerala·3d

@GallowayLabMIT @ZiboChen @ScienceMagazine @kaseyslove @jonesr18 @A_BlanchAsensio @science_sneha @DeonPloessl @emmapeterman_ @PZandstra @MummeryLab @MITChemE @MITdeptofBE Congratulations, great work! Also a great very detailed tweetorial.

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Katie Galloway@GallowayLabMIT·3d

@ArdemisPrime Thanks, Arde!

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Ardemis Boghossian@ArdemisPrime·3d

@GallowayLabMIT Congratulations Katieee!!!! Well deserved!

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Katie Galloway@GallowayLabMIT·5d

Wild to see this in print for the first time

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Katie Galloway@GallowayLabMIT·3d

@HaoYin20 thanks, Hao! I appreciate your sharing so much excellent work and the visibility you bring to ours :)

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Hao Yin@HaoYin20·3d

What a great thread & paper on Synthetic biology!🔥 Kudos to Dr. Galloway @GallowayLabMIT & team👏🥳 Gene syntax defines supercoiling-mediated transcriptional feedback science.org/doi/10.1126/sc…

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

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Katie Galloway@GallowayLabMIT·3d

@gaurav_ven thank you!

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