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Jamesb
2.1K posts
@experilearning One of my favorite examples: ageofem.com
Reading just the introduction and conclusion already gives you a lot.
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@fsfarimani I'm sure you can! I used build123d because that's what I used in the past but I imagine it would work with any code -> CAD language
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@experilearning Can you reverse engineer them back to OpenSCAD?
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@makeshifted Oh interesting I didn’t know build123d had a function for that. I checked the logs and scripts it made - can’t see any references to those docs or detect_primitives
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@experilearning Could you tell if it was using #stl-reconstruction-tutorial" target="_blank" rel="nofollow noopener">build123d.readthedocs.io/en/latest/tuto… as a reference?
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Jamesb retweetledi
I’ve wanted to do this for a decade.
But I never did - I refuse to give any company my DNA.
It is me.
So this week I sequenced my genome entirely at home. Literally on my kitchen table.
I never exposed my DNA sequence to the internet. Not at any point.
I used a MinION to do the sequencing (it’s smaller + weighs less than an iPhone).
I used open-source DNA models for the analysis (Evo2 and AlphaGenome) running locally on a DGX Spark and Mac Studio.
I traced mechanisms behind my family’s multigenerational autoimmune conditions that no clinician has been able to understand.
When I set out to do this I didn’t know if it would actually work. It does.
Your genome is the most private data you will ever have. You probably shouldn’t let it leave your house.
Patrick Collison@patrickc
I'm lucky enough to have a great doctor and access to excellent Bay Area medical care. I've taken lots of standard screening tests over the years and have tried lots of "health tech" devices and tools. With all this said, by far the most useful preventative medical advice that I've ever received has come from unleashing coding agents on my genome, having them investigate my specific mutations, and having them recommend specific follow-on tests and treatments. Population averages are population averages, but we ourselves are not averages. For example, it turns out that I probably have a 30x(!) higher-than-average predisposition to melanoma. Fortunately, there are both specific supplements that help counteract the particular mutations I have, and of course I can significantly dial up my screening frequency. So, this is very useful to know. I don't know exactly how much the analysis cost, but probably less than $100. Sequencing my genome cost a few hundred dollars. (One often sees papers and articles claiming that models aren't very good at medical reasoning. These analyses are usually based on employing several-year-old models, which is a kind of ludicrous malpractice. It is true that you still have to carefully monitor the agents' reasoning, and they do on occasion jump to conclusions or skip steps, requiring some nudging and re-steering. But, overall, they are almost literally infinitely better for this kind of work than what one can otherwise obtain today.) There are still lots of questions about how this will diffuse and get adopted, but it seems very clear that medical practice is about to improve enormously. Exciting times!
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Top centaur-era skill = leveraging massive search. How fast can you spam attempts in parallel and trial and error your way to success. Make trials as fast+cheap as possible, learn from failure, apply computational approaches creatively to domains people aren't using them
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There are so many lab tasks that can be made 1000x more reliable by effectively saying "Claude, hill-climb this for me pls..."
Jamesb@experilearning
Friendship with opencv is over, CNN is my new best friend, 2x better well localisation than yeaterday
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