Fahima Dossa, MD PhD

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Fahima Dossa, MD PhD

Fahima Dossa, MD PhD

@fdossa

Surgical Oncologist & Clinical Epidemiologist @CedarsSinai @DeptSurgeryCS | Soft Tissue Sarcoma & GI Malignancies | 🇨🇦

Katılım Ekim 2010
711 Takip Edilen1.2K Takipçiler
Dr. Nina Niu Sanford
Dr. Nina Niu Sanford@NiuSanford·
This is a great read on watch & wait in rectal cancer. B/c patients with local regrowth after WW have higher rates of distant mets, there has been an intuitive fear that regrowth is causal (i.e delaying TME permits metastatic seeding hence WW risky). The authors here argue (and I agree) that regrowth/metastases are manifestations of intrinsic aggressive tumor biology because: 1) no difference in time to surgery in patients w pCR/regrowth who developed mets vs. those who didn't (if delay were causal, would expect longer delay in patients who developed M1). 2) in OPRA secondary analysis, patients with cCR underwent least surgery/longest observation while those with incomplete response had surgery most frequently/immediately. But outcomes still tracked with response phenotype not timing of surgery (i.e. cCR did best). 3) tumor response itself is prognostic (i.e. even when all pts undergo TME, more regression after neoadjuvant therapy --> better DFS/DM). 4) modern tumor evolution data suggest metastatic spread mostly happens early. 5) chemo/radioresistance appears to be linked to metastatic potential (i.e. regrowth is a marker of aggressive biology not the mechanism itself). IMO a persuasive argument against hypothesis that regrowth seeds metastasis, but rather biology=dominant driver. @OncoAlert
Udhayvir Grewal@UGrewalMD

Watch and Wait for Rectal Cancer: A Risky Gamble or a Safe Strategy for Patients With a Near-Complete Response? | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…

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Fahima Dossa, MD PhD
Fahima Dossa, MD PhD@fdossa·
Thrilled to finally see this out - 🚨#Sarculator bayesian update for more refined risk estimates in extremity soft tissue sarcoma App📱update and @LancetOncology pub: sciencedirect.com/science/articl… Phenomenal work @DCalleMD, Gabriele Tine, et al. ! 👏🏽👏🏽
Dario Callegaro@DCalleMD

The #Sarculator app update is now live! This comes together with our @TheLancetOncol paper introducing #BayeSarc, a Bayesian sequential learning approach to refine prognostication in extremity soft tissue #sarcoma. Paper: sciencedirect.com/science/articl…
App: apps.apple.com/it/app/sarcula…

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Fahima Dossa, MD PhD
Fahima Dossa, MD PhD@fdossa·
@HannahRAbrams Thanks for highlighting! This is probably clearer in the paper but we purposely framed all outcomes such that further from center = better (eg tolerability rather than toxicity) So niro had ⬆️toxicity (incl ovarian suppression) but most rapid effect💨(?differences in study pops)
Fahima Dossa, MD PhD tweet media
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Jun Gong
Jun Gong@jgong15·
Incredibly fortunate/lucky to have my @NIH (5-yr) R01 converted to an @theNCI #R37 MERIT 7-yr award. Grateful to my mentors & the support of @ConquerCancerFd & @TowerCancer career development awards that paved the way for our work in novel #ctDNA assay development in #CRC (1/2)
Jun Gong tweet media
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Ashley Drohan
Ashley Drohan@drohan_ashley·
Congratulations Fahima!!!!
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Julie Hallet
Julie Hallet@HalletJulie·
Congrats @fdossa! 🎉 And congrats to @DeptSurgeryCS - you’ve got an outstanding surgeon and scientist there! Can’t wait to work together 😀
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