Michael Fralick

📬 Stay in the Loop with Medicine Pods! Sign up for our monthly newsletter at medicinepods.com to get the latest podcast episodes, medical infographics, and our monthly blog (qMonthly)—delivered straight to your inbox! 📷@InternAtWork @roundstable

🩺 New qMonthly is here! 1️⃣ Beta-blockers after MI: No benefit when LVEF ≥50% (HR 0.97) 2️⃣ Spironolactone in dialysis: No CV improvement (HR 0.92; stopped early for futility) Legacy practices under fire 🔥 #MedTwitter #Cardiology #EvidenceBasedMedicine #Dialysis

📢 New Nephro Trial Files! 🩸 Conservative dialysis boosts kidney recovery in AKI 💊 Pravastatin shows no benefit in early ADPKD 📉 Baxdrostat drops SBP by up to 15.7 mmHg in resistant HTN 🔗 nephrotrialfiles.substack.com/p/nephro-trial… #NephJC #MedTwitter #FOAMed #KidneyTwitter #Nephrology #RCT

🔁 Throwback Thursday: Diabetes Trial Files Edition 📌 Intensive glycemic control 📌 Captopril for diabetic nephropathy 📌 CABG/PCI vs. medical therapy in T2DM + CAD 🧵 Read more: diabetestrialfiles.substack.com/p/diabetes-tri… #Diabetes #Cardiology #Nephrology #FOAMed

🎙️ @RoundsTable Listeners, This week, Dr. @JohnFralick8 breaks down a new RCT comparing rituximab vs conventional therapy for inducing remission in EGPA #MedTwitter #FOAMed #MedEd #Rheumatology #EGPA #ClinicalTrials

📬 Stay in the Loop with Medicine Pods! Sign up for our monthly newsletter at medicinepods.com to get the latest podcast episodes and medical infographics, delivered straight to your inbox! #MedEd #MedTwitter

🫁 Confused by ABGs? @FralickMike's one-pager makes sense of: ✅Metabolic and respiratory acidosis/alkalosis ✅Key compensation patterns Grab the full book here: amazon.ca/One-Pagers-War… #MedTwitter #InternalMedicine

🎓 Residents & Royal College candidates, this one's for you: Unlock your exam success with our new “Royal  College  Resources” page — a curated hub of videos, podcasts & clinical‑practice guideline review. 👉 medicinepods.com/royal-college/ #RoyalCollege #MedEd #InternalMedicine

🎙️ @RoundsTable Listeners, This week Dr. @FralickMike is joined by returning guest Dr. Yatin Chadha to talk about his new beyond Radiology online course series! 🧠 CT Head Basics for Clinicians ❓ Artifact or Pathology? beyondmd.ca #MedTwitter #MedEd #Radiology

🎙️ New @RoundsTable infographics! 🩸 UGIB + Cirrhosis: Shorter/no antibiotics ≈ longer for mortality, slightly ↑ infection risk (JAMA IM 2025) 🫀 Dialysis + Spironolactone: No ↓ in CV death/HF hospitalization (Lancet 2025) #MedTwitter #FOAMed #MedEd #ClinicalTrials

🎙️ @RoundsTable Listeners, Dr. @FralickMike goes solo this week to unpack a new systematic review & meta-analysis on whether to continue or withhold RAS inhibitors before noncardiac surgery⚖️ #MedTwitter #FOAMed #MedEd #Cardiology #PerioperativeCare #ClinicalTrials

🎙️ @RoundsTable Listeners, We’re back with a Classic Rapid Fire episode! 🔥 Drs. Mike & John Fralick break down two new studies: 💊 Spironolactone in dialysis patients (ACHIEVE Trial) 🩸 Antibiotic prophylaxis for UGIB in cirrhosis #MedTwitter #MedEd #ClinicalTrials

🩸New Heme Onc Trial Files! 📌10-yr data on ibrutinib in CLL (RESONATE-2) 📌Ibrutinib+rituximab > chemo in MCL (ENRICH) 📌ATO+ATRA beats chemo in high-risk APL (APOLLO) Read more: hemeonctrialfiles.substack.com/p/hemeonc-tria… #HemeOnc #OncTwitter #CLL #MCL #APL #MedTwitter #ClinicalTrials #FOAMed

🎙️ @RoundsTable Listeners, Throwback time! ⏪ Dr. @FralickMike and guest Dr. Laiya Carayannopoulos revisit two key studies: 💨 Noninvasive airway management in comatose patients after acute poisoning 💊 PEN-FAST score for low-risk penicillin allergy #MedTwitter #MedEd

🎙️ @RoundsTable Listeners, Dr. @FralickMike breaks down a new trial comparing spironolactone vs amiloride for resistant hypertension — is amiloride noninferior? Let's find out! #MedTwitter #FOAMed #MedEd #Cardiology #Hypertension #ClinicalTrials

💊 IBD Trial Files Throwback 📸 Early colonoscopy + step-up therapy reduced Crohn’s recurrence post-surgery 🧪 Infliximab + azathioprine > either alone in SONIC Read now: ibdtrialfiles.substack.com/p/ibd-trial-fi… #Crohns #MedTwitter #FOAMed #Gastroenterology

🩸 Heme Onc Throwback Thursday 💊 Imatinib beat interferon in CML (87% vs 35% response) 🧬 Ruxolitinib outperformed BAT in PV (78% hematocrit control) 🔥 Midostaurin improved survival in FLT3-mutated AML Read now: hemeonctrialfiles.substack.com #HemeOnc #MedTwitter #Oncology

A new one pager on CKD. Feedback welcomed! Thank you to everyone who has provided feedback on earlier versions of it!

🎙️ @RoundsTable Listeners, Solo ep with @FralickMike! He reviews a new trial of aspirin in patients with chronic coronary syndrome on oral anticoagulation. #MedTwitter #Cardiology

🎙️ @RoundsTable Listeners: Hot off #ESC2025 Drs. @FralickMike & @JohnFralick8 break down K+ for arrhythmias, digitoxin in HFrEF, RSV vax, & apixaban for VTE in this Rapid Fire episode.

IBD Trial Files (ibdtrialfiles.substack.com) is a free monthly email newsletter that uses AI to find and summarize practice-changing randomized controlled trials in Inflammatory Bowel Disease. The newsletter helps medical trainees and physicians stay up-to-date on the latest advances in IBD research and treatment. Each edition features concise, clinically relevant trial summaries to keep you informed. Visit ibdtrialfiles.substack.com (ibdtrialfiles.substack.com) to check it out and subscribe. @zanegallinger @fralickmike @kat_zorcic